Results 61 to 70 of about 5,405 (175)

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, Volume 15, Issue 12, Page 2001-2020, December 2025.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Molecular dissection of mRNA poly(A) tail length control in yeast [PDF]

, 2008
In eukaryotic cells, newly synthesized mRNAs acquire a poly(A) tail that plays several fundamental roles in export, translation and mRNA decay. In mammals, PABPN1 controls the processivity of polyadenylation and the length of poly(A) tails during de novo
Afonina, Amrani, Anderson, Baer, Baer, Bienroth, Bouvet, Brown, Butler, Cartegni, De Vries, Deardorff, Dheur, Dichtl, Dunn, Edmonds, Florence Voisinet-Hakil, Ghisolfi, Hatfield, Hector, Hilleren, Hosoda, Kaufmann, Keller, Kelly, Kerwitz, Kiledjian, Kuhn, Lee, Lingner, Lionel Minvielle-Sebastia, Mandel, Marfatia, Martin, McBride, Mears, Meyer, Minvielle-Sebastia, Minvielle-Sebastia, Minvielle-Sebastia, Nicolas Viphakone, Perreault, Preker, Preker, Rigaut, Sachs, Sachs, Takagaki, Wahle, Wahle, Wahle, Weiss, Winstall, Zhao   +53 more
core   +5 more sources

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley   +1 more source

Comparative Genomics of Lactococcus spp. From Global Aquaculture Outbreaks Reveals Virulence Determinants, Antibiotic Resistance, and Phage Defence Mechanisms

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Lactococcus petauri predominated in isolates from outbreaks of lactococcosis, suggesting a shift in disease aetiology. Genomic analysis revealed diverse virulence factors, prophage and resistance genes, while antimicrobial susceptibility testing showed uniform resistance to common antibiotics found in farming systems, emphasising the need for ...
Adam M. Blanchard, Bailey Secker, Robert J. Atterbury, Samantha J. Windle, Ha Thanh Dong, Janchai Wongkaew, Le Thanh Dien, David Huchzermeyer, Bernard Mudenda Hang'ombe, Saengchan Senapin   +9 more
wiley   +1 more source

Synthesis and repair of 3'-end of tRNA molecule by tRNA nucleotidyltransferase [PDF]

, 2010
Enzim ATP(CTP):tRNA-nukleotidil-transferaza (CCA enzim) katalizira posttranskripcijsku sintezu i popravak slijeda CCA na 3'-kraju molekule tRNA, neophodnog u reakcijama translacije i stoga od životne važnosti za stanicu.
Hajdinjak, Mateja
core   +2 more sources

Expanding the diversity of mycobacteriophages: Insights into genome architecture and evolution [PDF]

, 2011
Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes ...
Agustin, B, Al-Atrache, Z, Alcoser, TA, Alexander, LM, Alfano, MB, Alford, ST, Amy, NE, Anderson, AG, Anderson, MD, Ang, AAS, Barber, AJ, Barker, LP, Barrett, JM, Barshop, WD, Bauerle, CM, Bayles, IM, Belfield, KL, Best, AA, Bowman, CA, Boyer, CA, Bradley, KW, Bradley, VA, Broadway, LN, Budwal, K, Busby, KN, Campbell, AM, Campbell, IW, Carey, A, Caruso, SM, Chew, RD, Cockburn, CL, Cohen, LB, Corajod, JM, Cresawn, SG, Davis, KR, Deng, L, Denver, DR, Dixon, BR, Ekram, S, Elgin, SCR, Engelsen, AE, English, BEV, Erb, ML, Estrada, C, Filliger, LZ, Findley, AM, Forbes, L, Forsyth, MH, Fox, TM, Fritz, MJ, Garcia, R, George, ZD, Georges, AE, Gissendanner, CR, Goff, S, Goldstein, R, Gordon, KC, Green, RD, Guerra, SL, Guiney-Olsen, KR, Guiza, BG, Haghighat, L, Hagopian, GV, Harmon, CJ, Harmson, JS, Hartzog, GA, Harvey, SE, He, KJ, He, S, Healy, KE, Higinbotham, ER, Hildebrandt, EN, Ho, JH, Hogan, GM, Hohenstein, VG, Holz, NA, Huang, VJ, Hufford, EL, Hynes, PM, Jackson, AS, Jacobs-Sera, D, Jansen, EC, Jarvik, J, Jasinto, PG, Jordan, TC, Kasza, T, Katelyn, MA, Kelsey, JS, Kerrigan, LA, Khaw, D, Kim, J, Knutter, JZ, Ko, CC, Larkin, GV, Laroche, JR, Latif, A, Manuel, A, Peebles, CL, Pope, WH, Russel, DA   +99 more
core   +1 more source

Genome‐Driven Analysis Reveals the Biotechnological Potential of a Novel Paenibacillus sp. Isolated From Crude Oil

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida, Carlos Miguel Nóbrega Mendonça, Leandro Marcio Moreira, Ricardo Pinheiro de Souza Oliveira, Alessandro de Mello Varani, Mauro de Medeiros Oliveira   +5 more
wiley   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Beyond tumour suppression: cGAS‐STING pathway in urologic malignancies: Context‐dependent duality and therapeutic implications

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
The context‐dependent duality of cGAS–STING signalling in urologic tumours is revealed. Targeting the STING pathway, in combination with immunotherapies and gene therapies, enhances the anti‐tumour response. Sex hormone differences in urological malignancies are correlated with the cGAS–STING pathway.
Qi Wei, Kui Zhao, Yifan Wu, Wenhui Wu, Na Hao   +4 more
wiley   +1 more source

Expression, Enzymatic Activities and Subcellular Localization of Hepatitis E Virus and Semliki Forest Virus Replicase Proteins [PDF]

, 2006
Viruses are submicroscopic, infectious agents that are obligate intracellular parasites. They adopt various types of strategies for their parasitic replication and proliferation in infected cells.
Perttilä, Julia
core