Results 101 to 110 of about 203,837 (307)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation

eLife, 2012
A substantial fraction of the metazoan transcriptome undergoes circadian oscillations in many cells and tissues. Based on the transcription feedback loops important for circadian timekeeping, it is commonly assumed that this mRNA cycling reflects ...
Jerome S Menet, Joseph Rodriguez, Katharine C Abruzzi, Michael Rosbash   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration

Cell Reports
Summary: Motor neuron (MN) demise is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Post-transcriptional gene regulation can control RNA’s fate, and defects in RNA processing are critical determinants of ...
Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Paola Rinchetti, Patricia M.S. Passos, Alliny Bastos, Yuna M. Ayala, Jacob H. Hanna, Serge Przedborski, Dario Bonanomi, Mattia Pelizzola, Francesco Lotti   +12 more
doaj   +1 more source

N6‐methyladenosine and RNA secondary structure affect transcript stability and protein abundance during systemic salt stress in Arabidopsis

Plant Direct, 2020
After transcription, a messenger RNA (mRNA) is further post‐transcriptionally regulated by several features including RNA secondary structure and covalent RNA modifications (specifically N6‐methyladenosine, m6A). Both RNA secondary structure and m6A have
Marianne C. Kramer, Kevin A. Janssen, Kyle Palos, Andrew D. L. Nelson, Lee E. Vandivier, Benjamin A. Garcia, Eric Lyons, Mark A. Beilstein, Brian D. Gregory   +8 more
doaj   +1 more source

Post-transcriptional regulation of microRNA expression

, 2006
microRNAs ( miRNAs) are endogenous, noncoding similar to 22-nucleotide RNA molecules that have recently emerged as fundamental, post-transcriptional regulators of cognate target gene expression.
Alenius, Matias,, Martinez, J,, Obernosterer, G,, Leuschner, PJF,   +3 more
core   +1 more source

Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptome. [PDF]

, 2010
The complexity of the eukaryotic transcriptome is generated by the interplay of transcription initiation, termination, alternative splicing, and other forms of post-transcriptional modification. It was recently shown that RNA transcripts may also undergo
Bracken, CP, Cameron P. Bracken, Marjan E. Askarian-Amiri, Gregory J. Goodall, Kolle, Gabriel, Korbie, D., Gardiner, B., Gardiner, Brooke B., Grimmond, SM, Marcel E. Dinger, Tim R. Mercer, Mattick, J., Goodall, GJ, Askarian-Amiri, M., Sean M. Grimmond, John S. Mattick, Mercer, TR, Jan M. Szubert, Szubert, J., Dinger, Marcel E., Bracken, C., Brooke B. Gardiner, Korbie, DJ, Kolle, G., Mattick, JS, Szubert, Jan M., Kolle, G, Goodall, Gregory J., Bracken, Cameron P., Askarian-Amiri, Marjan E., Gabriel Kolle, Darren J. Korbie, Goodall, G., Gardiner, BB, Dinger, M., Grimmond, S., Askarian Amiri, Effat, Grimmond, Sean M., Mattick, John S., Korbie, Darren J., Dinger, ME, Mercer, Tim R., Szubert, JM, Mercer, T.   +43 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10

Cells, 2019
Ribosome biogenesis is one of the most energy demanding processes in the cell. In eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal RNA (pre-rRNA) processing, post-transcriptional modifications, and assembly of ...
Sophie Sleiman, Francois Dragon
doaj   +1 more source

The Zinc Finger Protein ZNF658 Regulates the Transcription of Genes Involved in Zinc Homeostasis and Affects Ribosome Biogenesis through the Zinc Transcriptional Regulatory Element

, 2015
We previously identified the ZTRE (zinc transcriptional regulatory element) in genes involved in zinc homeostasis and showed that it mediates transcriptional repression in response to zinc. We now report that ZNF658 acts at the ZTRE.
Ogo, Ogo A., Tyson, John, Cockell, Simon, Howard, Alison, Valentine, Ruth, Ford, Dianne   +5 more
core   +1 more source