Results 191 to 200 of about 287,328 (279)

Structural insights into transcriptional regulation by the helicase RECQL5. [PDF]

Nat Struct Mol Biol
Florez Ariza AJ, Lue NZ, Grob P, Kaeser B, Fang J, Kassube SA, Nogales E.   +6 more
europepmc   +1 more source

Processing and turn-over of small non-coding RNA OxyS in E. coli & post-transcriptional regulation of RpoS levels by small non-coding RNAs OxyS and DsrA and the Hfq protein in E. coli

, 2010
rpoS mRNA is one of the first target RNA shown to be regulated by at least 3 small noncoding RNAs under various stress conditions. Two out of three sRNAs are involved in the activation of rpoS mRNA translation. By contrast the third sRNA, OxyS has been implicated in the repression of RpoS synthesis.
openaire   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

How influenza A virus NS1 impedes transcription of the host cell's messenger RNAs. [PDF]

Npj Viruses
Marc D.
europepmc   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Regulatory orchestration of FK506 biosynthesis in <i>Streptomyces tsukubaensis</i> NRRL 18488 revealed through systematic analysis. [PDF]

iScience
Lee N, Kim W, Kim JH, Lee Y, Hwang S, Kim G, Kim H, Dan Q, Schmidt M, Yoon YJ, Cho S, Palsson B, Keasling JD, Cho BK.   +13 more
europepmc   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Epitranscriptomic Control of Drought Tolerance in Rice: The Role of RNA Methylation. [PDF]

Plants (Basel)
Fan X, Zhang Y, Gu P, Naz M.
europepmc   +1 more source

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes. [PDF]

Nucleic Acids Res
Peterman EL, Ploessl DS, Love KS, Sanabria V, Daniels RF, Johnstone CP, Godavarti DR, Kabaria SR, Oakes CG, Pai AA, Galloway KE.   +10 more
europepmc   +1 more source