Results 21 to 30 of about 19,175,801 (290)

Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia

Biology Open, 2022
Mature transfer (t)RNAs are generated by multiple RNA processing events, which can include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) complex is responsible for cleaving these intron-containing pre-tRNA transcripts.
Casey A. Schmidt, Lucy Y. Min, Michelle H. McVay, Joseph D. Giusto, John C. Brown, Harmony R. Salzler, A. Gregory Matera   +6 more
doaj   +1 more source

The FASTK family proteins fine-tune mitochondrial RNA processing

PLoS Genetics, 2021
Transcription of the human mitochondrial genome and correct processing of the two long polycistronic transcripts are crucial for oxidative phosphorylation.
Akira Ohkubo, L. Van Haute, Danielle L. Rudler, Maike Stentenbach, F. Steiner, O. Rackham, M. Minczuk, A. Filipovska, J. Martinou   +8 more
semanticscholar   +1 more source

Ribonuclease E strongly impacts bacterial adaptation to different growth conditions

RNA Biology, 2023
Adaptation of bacteria to changes in their environment is often accomplished by changes of the transcriptome. While we learned a lot on the impact of transcriptional regulation in bacterial adaptation over the last decades, much less is known on the role
Janek Börner, Tobias Friedrich, Marek Bartkuhn, Gabriele Klug   +3 more
doaj   +1 more source

Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases

Frontiers in Genetics, 2014
The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3 ...
Kozo eTomita, Seisueke eYamashita
doaj   +1 more source

Repositioning the Sm-Binding Site in Saccharomyces cerevisiae Telomerase RNA Reveals RNP Organizational Flexibility and Sm-Directed 3′-End Formation

Non-Coding RNA, 2020
Telomerase RNA contains a template for synthesizing telomeric DNA and has been proposed to act as a flexible scaffold for holoenzyme protein subunits in the RNP.
Evan P. Hass, David C. Zappulla
doaj   +1 more source

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

Nucleic Acids Res., 2012
SILVA (from Latin silva, forest, http://www.arb-silva.de) is a comprehensive web resource for up to date, quality-controlled databases of aligned ribosomal RNA (rRNA) gene sequences from the Bacteria, Archaea and Eukaryota domains and supplementary ...
Christian Quast, E. Pruesse, Pelin Yilmaz, Jan Gerken, Timmy Schweer, P. Yarza, J. Peplies, F. Glöckner   +7 more
semanticscholar   +1 more source

Arabidopsis RanBP2-Type Zinc Finger Proteins Related to Chloroplast RNA Editing Factor OZ1

Plants, 2020
OZ1, an RNA editing factor that controls the editing of 14 cytidine targets in Arabidopsis chloroplasts, contains two RanBP2-type zinc finger (Znf) domains. The RanBP2 Znf is a C4-type member of the broader zinc finger family with unique functions and an
Andrew B. Gipson, Ludovic Giloteaux, Maureen R. Hanson, Stephane Bentolila   +3 more
doaj   +1 more source

FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications

Scientific Reports, 2023
FUS is a multifunctional protein involved in many aspects of RNA metabolism, including transcription, splicing, translation, miRNA processing, and replication-dependent histone gene expression.
Kishor Gawade, Patrycja Plewka, Sophia J. Häfner, Anders H. Lund, Virginie Marchand, Yuri Motorin, Michal W. Szczesniak, Katarzyna D. Raczynska   +7 more
doaj   +1 more source

Comprehensive Characterization of RNA Processing Factors in Gastric Cancer Identifies a Prognostic Signature for Predicting Clinical Outcomes and Therapeutic Responses

Frontiers in Immunology, 2021
RNA processing converts primary transcript RNA into mature RNA. Altered RNA processing drives tumor initiation and maintenance, and may generate novel therapeutic opportunities.
Shenghan Lou, Fanzheng Meng, Xin Yin, Yao Zhang, Bangling Han, Yingwei Xue   +5 more
doaj   +1 more source

ReadZS detects cell type-specific and developmentally regulated RNA processing programs in single-cell RNA-seq

Genome Biology, 2022
RNA processing, including splicing and alternative polyadenylation, is crucial to gene function and regulation, but methods to detect RNA processing from single-cell RNA sequencing data are limited by reliance on pre-existing annotations, peak calling ...
Elisabeth Meyer, Kaitlin Chaung, Roozbeh Dehghannasiri, Julia Salzman   +3 more
doaj   +1 more source