Results 11 to 20 of about 836,536 (329)
RNA World with Inhibitors [PDF]
EntropyDuring the evolution of the RNA World, compartments, which were fragments of space surrounded by a primitive lipid membrane, had to have emerged. These led eventually to the formation of modern cellular membranes.
Jaroslaw Synak +3 more
doaj +4 more sources
Order and Complexity in the RNA World [PDF]
Life, 2023 The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient prebiotic evolution.
Christian Mayer
doaj +2 more sources
From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution [PDF]
Cells, 2021 The current SARS-CoV-2 pandemic underscores the importance of understanding the evolution of RNA genomes. While RNA is subject to the formation of similar lesions as DNA, the evolutionary and physiological impacts RNA lesions have on viral genomes are ...
Zachary W. Kockler, Dmitry A. Gordenin
doaj +3 more sources
, 2011 Nisu pronađeni nikakvi dokazi o postojanju precelularnog života. Svi zaključci o njegovom postojanju su pretpostavke. Iako je teško zamisliti nastanak života iz neživog, precelularni život se morao pojaviti u vrlo kratkom vremenu.
Čule, Ana-Marija
core +6 more sources
RNA World Modeling: A Comparison of Two Complementary Approaches [PDF]
Entropy, 2022 The origin of life remains one of the major scientific questions in modern biology. Among many hypotheses aiming to explain how life on Earth started, RNA world is probably the most extensively studied.
Jaroslaw Synak +2 more
doaj +2 more sources
Kin Selection in the RNA World [PDF]
Life, 2017 Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions.
Samuel R. Levin, Stuart A. West
doaj +2 more sources
Rethinking the tools of the RNA world [PDF]
eLife, 2018 An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.
Antony Crisp, Thomas Carell
doaj +2 more sources
The RNA world of fungal pathogens. [PDF]
PLoS Pathogens, 2023 Srimeenakshi Sankaranarayanan +3 more
doaj +2 more sources
Cold Spring Harb Perspect Biol, 2018 Although we live in the remnants of an RNA world, the world of drug discovery and chemical probes is firmly protein-centric. Developing highly selective small molecules targeting RNA is often considered to be an insurmountable challenge. Our goal is to demystify the design of such compounds.
Disney MD, Dwyer BG, Childs-Disney JL.
europepmc +4 more sources
RNA, 2015 My research entered the RNA world when I joined the EMBL Heidelberg. During my doctoral and postdoctoral research I had focused on developing and applying solution NMR methods and studied protein structure and dynamics of the Bcl family proteins, which are important regulators of apoptosis.
Michael Sattler
openaire +4 more sources