Results 31 to 40 of about 267,874 (284)

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals [PDF]

, 2014
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs harboring premature termination codons (PTCs). We have conducted a genome-wide RNAi screen in Caenorhabditis elegans that resulted in the identification of five novel NMD ...
Ailion M, Angela Casadio, Brand AH, Claudio R Alonso, Dasa Longman, Javier F Cáceres, Laurent Delavaine, Nele Hug, Raúl Vallejos Baier   +8 more
core   +2 more sources

Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth

Biomolecules, 2020
Cutaneous melanoma is the most aggressive skin cancer with notorious drug resistance. Inhibition of immune checkpoint molecules is one of the most promising approaches for cancer therapy.
Ehexige Ehexige, Mingming Bao, Purevbat Bazarjav, Xiang Yu, Hai Xiao, Shuqin Han, Huricha Baigude   +6 more
doaj   +1 more source

Genome-wide Identification and Bioinformatics Analysis of Scavenger Receptor Gene Family in Plutella xylostella

Guangdong nongye kexue, 2023
【Objective】The resistance of Plutella xylostella to chemical insecticides is increasing year by year, which makes RNAi (RNA interference) pesticides widely concerned. The P.
Jianbin TAN, Jin XU, Peiqiong SHI, Hongkai ZHOU   +3 more
doaj   +1 more source

RNA interference in marine and freshwater sponges [PDF]

, 2011
Background: The marine sponge Tethya wilhelma and the freshwater sponge Ephydatia muelleri are emerging model organisms to study evolution, gene regulation, development, and physiology in non-bilaterian animal systems. Thus far, functional methods (i.e.,
Cieniewicz, Brandon, Danka, Elizabeth S., Haen, Karri M., Hammel, Jörg U., Hill, April L., Hill, Malcolm S., Knight, Scott W., Lavrov, Dennis V., Nickel, Michael, Posfai, Dora, Rivera, Ajna S., Winters, Ian P., Wörheide, Gert   +12 more
core   +1 more source

Limitations in harnessing oral RNA interference as an antiviral strategy in Aedes aegypti

iScience
Summary: Mosquitoes, particularly Aedes aegypti, are critical vectors for globally significant pathogenic viruses. This study examines the limitations of oral RNA interference (RNAi) as a strategy to disrupt viral transmission by Ae. aegypti.
Ottavia Romoli, Annabelle Henrion-Lacritick, Hervé Blanc, Lionel Frangeul, Maria-Carla Saleh   +4 more
doaj   +1 more source

RNAi in Clinical Studies [PDF]

Current Medicinal Chemistry, 2013
RNA interference (RNAi) is an efficient process of posttranscriptional gene silencing. In recent years it has been developed into a new technology in biopharmaceutical fields of science. RNAi products include short interference RNA (siRNA) but also short hairpin RNA (shRNA), bifunctional short hairpin RNA (bi-shRNA) and microRNA (miRNA).
P, Kubowicz, D, Żelaszczyk, E, Pękala
openaire   +2 more sources

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. [PDF]

, 2015
The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised
Abdou, Al-Anzi, Antonello, Athippozhy, Avila, Bajgar, Barnes, Biteau, Biteau, Bontonou, Buchon, Busson, Carey, Carvalho, Casirola, Cerf, Charles, Choi, Cognigni, David, Economos, Fahrbach, Flatt, Flatt, Flatt, Glinoer, Gore, Gwinn, Hammond, Hansen, Hildebrandt, Horton, Jiang, Jindra, Jindra, Jowett, Keller, Klepsatel, Koren, Koyama, Kubli, Kunte, Langevin, Lee, Lemaitre, Li, Lodhi, Marianes, Marois, McGuire, Micchelli, Middleton, Min, Mirth, Mirth, Moshitzky, Navare, Nijhout, O'Brien, Padmanabha, Palm, Parker, Parra-Peralbo, Phillips, Piersma, R Development Core Team, Rauschenbach, Rera, Riddiford, Roa, Rogina, Ryu, Sarraf-Zadeh, Schneider, Seegmiller, Shimano, Shin, Sieber, Siegmund, Song, Speakman, Theopold, Tiu, Ueyama, Venables, Wen, Wigby, Wyatt, Yamamoto, Yin, Zhang   +90 more
core   +2 more sources

Exit from Pluripotency Assay of Mouse Embryonic Stem Cells

Bio-Protocol, 2017
A novel method to assess the dissolution of the core pluripotency transcription-factor circuit of mouse Embryonic Stem Cells (mESCs) has been developed (Ying et al., 2003; Betschinger et al., 2013).
Daniel Cirera-Salinas, Constance Ciaudo
doaj   +1 more source

Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]

, 2014
Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Coombs, Graham H., Jones, Nathaniel G., Mottram, Jeremy C., Proto, William R.   +3 more
core   +3 more sources

A robust in-vitro and ex-vitro Agrobacterium rhizogenes-mediated hairy root transformation system in mungbean for efficient visual screening of transformants using the RUBY reporter

BMC Plant Biology
Background Mungbean is one of the most economically important grain legume crops in Asia. Functional genomics studies in mungbean are necessary to understand the molecular mechanisms behind agronomic traits, to advance the crop improvement. However, this
Sanjeev Kumar, Sakshi Prakash, Priti Kumari, Neeti Sanan-Mishra   +3 more
doaj   +1 more source