Results 61 to 70 of about 365,508 (294)

Targeted RNase: Human Antibody-RNase-Fusions against CD30+ lymphomas [PDF]

, 2007
Die steigende Bedeutung der antikörperbasierten Krebstherapie spiegelt sich in der stark gestiegenen Anzahl in klinischen Studien befindlicher mAk wider. Zusätzlich stehen insbesondere Antikörperfusionen zur Funktionserweiterung im Mittelpunkt.
Menzel, Christian
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

RNase P RNA-mediated catalysis

, 2002
The endoribonuclease RNase P is involved in the processing of tRNA precursors to generate mature 5' termini. The catalytic activity of RNase P is associated with an RNA, RNase P RNA.
Kirsebom, Leif A.,
core   +7 more sources

Nickel affects xylem Sap RNase a and converts RNase A to a urease [PDF]

BMC Plant Biology, 2013
Nickel (Ni) is an essential micronutrient; however, its metabolic or physiological functions in plants and animals are largely uncharacterized. The ribonucleases (RNase, e.g., RNase A) are a large family of hydrolases found in one form or many forms facilitating nitrogen (N) cycling.
Bai, Cheng, Liu, Liping, Wood, Bruce W
openaire   +2 more sources

Role of Translesion Synthesis (TLS) polymerases in rNMPs incorporation during DNA replication

, 2014
Ribonuclease H (RNase H) are evolutionary conserved enzymes that cleave the RNA moiety in RNA:DNA hybrid molecules. It has been found that replicative DNA polymerases can incorporate rNTPs in place of dNTPs during DNA replication with an unexpected high ...
A. Meroni, P. Plevani, S. Sertic, F. Lazzaro, Sara Pizzi, M. Muzi Falconi, Thomas A. Kunkel, D. Delmastro, Peter M. J. Burger   +8 more
core   +2 more sources

Degradation by Stratum Corneum Proteases Prevents Endogenous RNase Inhibitor from Blocking Antimicrobial Activities of RNase 5 and RNase 7 [PDF]

, 2009
The antimicrobial defense of the skin is partially mediated by RNase 7, an abundant ribonuclease of the stratum corneum (SC). Here, we investigated the expression and regulation of members of the RNase A family and of the endogenous RNase inhibitor (RI ...
Arby Abtin, Eckhart, Leopold, Abtin, Arby, Minoo Ghannadan, Ghannadan, Minoo, Jens-Michael Schröder, Tschachler, Erwin, Erwin Tschachler, Michael Mildner, Schröder, Jens-Michael, Leopold Eckhart, Mildner, Michael, Harder, Jürgen, Jürgen Harder   +13 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Human serum RNase-L level is inversely associated with metabolic syndrome and age

Cardiovascular Diabetology, 2017
Background Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents.
Yi-Ting Wang, Ping-Huei Tseng, Chi-Ling Chen, Der-Sheng Han, Yu-Chiao Chi, Fen-Yu Tseng, Wei-Shiung Yang   +6 more
doaj   +1 more source

Expression and trans-specific polymorphism of self-incompatibility RNases in coffea (Rubiaceae). [PDF]

PLoS ONE, 2011
Self-incompatibility (SI) is widespread in the angiosperms, but identifying the biochemical components of SI mechanisms has proven to be difficult in most lineages. Coffea (coffee; Rubiaceae) is a genus of old-world tropical understory trees in which the
Michael D Nowak, Aaron P Davis, François Anthony, Anne D Yoder   +3 more
doaj   +1 more source

Molecular cloning and characterization of the human RNase  , an ortholog of Cc RNase [PDF]

Nucleic Acids Research, 2007
A novel protein family, designated hereafter as RNase kappa (kappa) family, has been recently introduced with the characterization of the specific Cc RNase, isolated from the insect Ceratitis capitata. The human ortholog of this family consists of 98 amino acids and shares > 98% identity with its mammalian counterparts.
Economopoulou, M.-A.I., Fragoulis, E.G., Sideris, D.C.   +2 more
openaire   +3 more sources