Results 71 to 80 of about 508,134 (310)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Human serum RNase-L level is inversely associated with metabolic syndrome and age

Cardiovascular Diabetology, 2017
Background Ribonuclease-L (RNase-L) was known to be a ubiquitous enzyme involved in several cellular functions, especially innate immunity. It was recently shown to participate in adipogenesis in rodents.
Yi-Ting Wang, Ping-Huei Tseng, Chi-Ling Chen, Der-Sheng Han, Yu-Chiao Chi, Fen-Yu Tseng, Wei-Shiung Yang   +6 more
doaj   +1 more source

Two tandem RNase III cleavage sites determine betT mRNA stability in response to osmotic stress in Escherichia coli. [PDF]

PLoS ONE, 2014
While identifying genes regulated by ribonuclease III (RNase III) in Escherichia coli, we observed that steady-state levels of betT mRNA, which encodes a transporter mediating the influx of choline, are dependent on cellular concentrations of RNase III ...
Minji Sim, Boram Lim, Se-Hoon Sim, Daeyoung Kim, Euihan Jung, Younghoon Lee, Kangseok Lee   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Nature Communications, 2020
Ribozyme-based RNase MRP is an essential eukaryotic enzyme involved in the maturation of rRNA and is evolutionarily related to RNase P. Here, the authors present the 3.0 Å cryo-EM structure of the S.
Anna Perederina, Di Li, Hyunwook Lee, Carol Bator, Igor Berezin, Susan L. Hafenstein, Andrey S. Krasilnikov   +6 more
doaj   +1 more source

RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue

Frontiers in Physiology, 2020
Background: RNase A (the bovine equivalent to human RNase 1) and RNase 5 (angiogenin) are two closely related ribonucleases. RNase 5 is described as a powerful angiogenic factor.
Manuel Lasch, Manuel Lasch, Manuel Lasch, Konda Kumaraswami, Konda Kumaraswami, Simona Nasiscionyte, Susanna Kircher, Susanna Kircher, Dominic van den Heuvel, Sarah Meister, Hellen Ishikawa-Ankerhold, Hellen Ishikawa-Ankerhold, Elisabeth Deindl, Elisabeth Deindl   +13 more
doaj   +1 more source

The first small-molecule inhibitors of members of the ribonuclease E family [PDF]

, 2015
The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression.
A Danchin, A Koul, AJ Callaghan, AJ Callaghan, AJ Callaghan, AJ Carpousis, AJ Carpousis, AP Walsh, AR Subramanian, BK Ghora, BK Mohanty, BK Shoichet, C Condon, C Condon, C Dye, CM Arraiano, D Apirion, D Suck, GA Mackie, JE Clarke, K Lee, KH Bleicher, KJ McDowall, KJ McDowall, L Kime, L Kime, M Kuwano, M Ono, M Wachi, MC Ow, MHJ Seifert, MJ Marcaida, N Guex, O Guner, O Zelenko, SM Garrey, SS Jourdan, V Khemici, VJ Gillet, VR Kaberdin, XQ Jiang, Y Redko, Z Zsoldos, ZW Li   +43 more
core   +4 more sources

Antibiotics and RNase P [PDF]

Antibiotics, 2016
RNase P is an essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. Most forms of RNase P are ribonucleoproteins, i.e., they consist of an essential RNA and protein subunits. The catalytic function of ribonucleoprotein RNase P enzymes resides entirely in the RNA subunit.
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Genetic diversity of human RNase 8

BMC Genomics, 2012
Background Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent ...
Chan Calvin C, Moser Jennifer M, Dyer Kimberly D, Percopo Caroline M, Rosenberg Helene F   +4 more
doaj   +1 more source