Structure of chloramphenicol-bound MexB reveals residues in the distal binding pocket that are critical for substrate recognition. [PDF]
J BiochemUeda Y +4 more
europepmc +1 more source
Strain-dependent contribution of the AcrAB-TolC efflux pump to Klebsiella pneumoniae physiology
Bhogal K +6 more
europepmc +1 more source
RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pump
Microbial Genomics, 2023 Acinetobacter are generally soil-dwelling organisms that can also cause serious human infections. A. baumannii is one of the most common causative agents of
Elizabeth M Darby +2 more
exaly +3 more sources
Evolution of RND efflux pumps in the development of a successful pathogen
Drug Resistance Updates, 2023 This study examined the origins and evolution of the AdeABC, AdeFGH and AdeIJK efflux pumps in the Acinetobacter genus, including human and animal pathogens and species from non-clinical environments.Comparative genome analyses were performed using the reference sequences for 70 Acinetobacter species to identify putative orthologs of AdeABC, AdeFGH and
Varsha Naidu +2 more
exaly +4 more sources
Computer simulations of the activity of RND efflux pumps
Research in Microbiology, 2018 The putative mechanism by which bacterial RND-type multidrug efflux pumps recognize and transport their substrates is a complex and fascinating enigma of structural biology. How a single protein can recognize a huge number of unrelated compounds and transport them through one or just a few mechanisms is an amazing feature not yet completely unveiled ...
Attilio V Vargiu +2 more
exaly +5 more sources
Related searches:
Structures and Transport Mechanisms of RND Efflux Pumps
2016Multidrug efflux transporters of the resistance-nodulation-cell division (RND) superfamily are one of the main causes of multidrug resistance (MDR) in Gram-negative bacteria. These proton motive force-dependent transporters generally occur as tripartite efflux complexes that span the cytoplasmic and outer membranes, thus providing a mechanism to ...
Satoshi Murakami, Murakami Satoshi
exaly +2 more sources
Resistance in gram-negative bacilli: the emergence of RND efflux pumps
Future MicrobiologyThe rise of antimicrobial resistance has been a significant problem in recent decades, decreasing the effectiveness of antibiotics and making the treatment of infections increasingly difficult. This phenomenon can be acquired through various mechanisms, with antibiotic efflux mediated by proteins known as efflux pumps being one of the most important ...
Maria Anndressa Alves Agreles +2 more
exaly +3 more sources
Reconstitution of the activity of RND efflux pumps: a “bottom-up” approach
Research in Microbiology, 2018Efflux pumps are systems devoted to the extrusion of noxious compounds. In this review, we discuss the various strategies that have thus far been undertaken for the investigation of efflux pumps after reconstitution into liposomes. It is challenging to uncover mechanisms and dynamics of efflux pumps due to a number of characteristics: their function ...
Puvanendran, Dhenesh +2 more
openaire +3 more sources
RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms
Current Topics in Medicinal Chemistry, 2013Efflux pumps of the Resistance Nodulation Division (RND) superfamily play a major role in the intrinsic and acquired resistance of Gram-negative pathogens to antibiotics. Moreover, they are largely responsible for multi-drug resistance (MDR) phenomena in these bacteria.
Ruggerone +4 more
openaire +3 more sources
Calcium induces tobramycin resistance in Pseudomonas aeruginosa by regulating RND efflux pumps
Cell Calcium, 2017Pseudomonas aeruginosa is an opportunistic multidrug resistant pathogen causing severe chronic infections. Our previous studies showed that elevated calcium (Ca2+) enhances production of several virulence factors and plant infectivity of the pathogen. Here we show that Ca2+ increases resistance of P.
Sharmily Khanam +2 more
exaly +3 more sources