Results 101 to 110 of about 179,366 (172)
Multifunctional Bacterial Multi-Drug Efflux Pumps – not just for resistance
, 2006 It is well established that multidrug-resistance efflux pumps encoded by bacteria can confer clinically relevant resistance to antibiotics. It is now understood that these efflux pumps also have a physiological role(s).
Piddock, Laura, Laura J. V. Piddock
core +1 more source
Expression of homologous RND efflux pump genes is dependent upon AcrB expression:implications for efflux and virulence inhibitor design [PDF]
, 2015 OBJECTIVES: Enterobacteriaceae have multiple efflux pumps that confer intrinsic resistance to antibiotics. AcrB mediates clinically relevant multidrug resistance and is required for virulence and biofilm formation, making it an attractive target for the ...
Blair, Jessica M A; id_orcid +5 more
core +1 more source
QsdH is localized in the inner membrane of a RND-type multidrug efflux transporter.
, 2013 The alignment of the ORF protein with two multidrug efflux pumps was showed. 1, ORF protein; 2, CzcA family heavy metal efflux protein from Alteromonas spp.
Ziduo Liu (184600) +6 more
core +1 more source
The highly conserved domain of RND multidrug efflux pumps in pathogenic Gram-negative bacteria
, 2018 RND (Resistance-Nodulation-Division) family transporters have a vital role in both intrinsic and acquired multi-drug resistance in Gram-negative bacteria.
Shahini Shams Abadi, Milad +2 more
core
Contribution of RND-type efflux pumps in reduced susceptibility to biocides in Acinetobacter baumannii [PDF]
Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Meyer, Christina
core
, 2000 Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a large number of antibiotics. Effective antibiotic transport has now been observed for many classes of drug efflux pumps.
Van Bambeke, Françoise +5 more
core +1 more source
PLoS ONEMycobacterium abscessus is a biofilm-forming, non-tuberculous mycobacterium that is highly resistant to antibiotics. Bacterial efflux pumps contribute to biofilm formation, export of biofilm-associated lipids and antibiotic tolerance.
Timilehin Faboro, Jaiyanth Daniel
doaj +1 more source
Efflux pumps of the resistance-nodulation-cell division (RND) superfamily, particularly the AcrAB-TolC, and MexAB-OprM, besides mediating intrinsic and acquired resistance, also intervene in bacterial pathogenicity. Inhibitors of such pumps could restore
Nisha Mahey +10 more
core +1 more source
Iranian South Medical Journal, 2009 Background: The presence of antibiotic resistance has been reported in H.pylori and it is a major cause of treatment failure. Five families of multidrug efflux pumps are defined in bacteria and resistance-nodulation-division (RND) pumps are found mainly ...
Mohammad hasan Shirazi +7 more
doaj