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The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump
Biological Chemistry, 2015Abstract Microorganisms encode several classes of transmembrane molecular pumps that can expel a wide range of chemically distinct toxic substances. These machines contribute to the capacity of the organisms to withstand harsh environments, and they help to confer resistance against clinical antimicrobial agents.
Dijun, Du +4 more
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Screening of Natural Products and Derivatives for the Identification of RND Efflux Pump Inhibitors
Combinatorial Chemistry & High Throughput Screening, 2016Overexpression of efflux pumps belonging to the Resistance Nodulation cell Division (RND) family is the most important intrinsic resistance mechanism of Pseudomonas aeruginosa. Hence, it is imperative to identify suitable efflux pump inhibitors (EPI) that can lead to increased intracellular concentration of antibiotics by blocking the pump.
Debarati, Choudhury +4 more
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Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update
Current Opinion in Microbiology, 2009Resistance nodulation division efflux systems have a major role in both intrinsic and acquired multi-drug resistance in Gram-negative bacteria. The recent structure of an assembled tripartite system, AcrAB-TolC, revealed that AcrB is docked onto TolC, which remains in an open state once part of the assembled complex and three AcrA molecules complete ...
Jessica M A, Blair, Laura J V, Piddock
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Contributions of RND efflux pumps to bacterial virulence
All cells need to export waste and toxic products. Gram-negative bacteria evolved multi-subunit, tripartite efflux pumps that export molecules from the periplasm through the outer membrane. The Resistance-Nodulation-Division (RND) family of efflux pumps are best known for expelling antibiotics, but they are also critical for infection in the absence ofopenaire +1 more source
RND efflux pump and its interrelationship with quorum sensing system.
Yi chuan = Hereditas, 2017Antibiotic resistance has become a serious concern in treatment of bacterial infections. Overexpression of efflux pump is one of the important mechanisms in antibiotic resistance. In Gram negative bacteria, RND (Resistance-nodulation-cell division) superfamily efflux pump plays a vital important role in antibiotics resistance.
Zhi-bin, Liang +4 more
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RND Efflux Pumps in Gram-Negative Bacteria; Regulation, Structure and Role in Antibiotic Resistance
Future Microbiology, 2020Ilyas Alav +2 more
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Acinetobacter baumannii RND efflux pump regulators and their impact on antimicrobial susceptibility
2022A. baumannii has been assigned as one of the most urgent threats among antimicrobial resistant bacterial organisms. The fundamental mechanism of action of antimicrobial agents is to bind to its bacterial target site and to interfere with cellular processes causing impaired bacterial cell growth or lead to bacterial cell death. A. baumannii is known for
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RND Efflux Systems Contribute to Resistance and Virulence of Aliarcobacter butzleri
Antibiotics, 2021Cristiana Mateus +2 more
exaly