Results 21 to 30 of about 1,691 (128)

Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Benjamin NR, Madrigal G, Ishida Y, Catchen J, Allen KL, Pepin B, Roca AL.   +6 more
europepmc   +2 more sources

Virus Safety of Xenotransplantation [PDF]

, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Denner, Joachim
core   +2 more sources

Presence of porcine cytomegalovirus, a porcine roseolovirus, in wild boars in Italy and Germany [PDF]

, 2023
Porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV) that is closely related to human herpesviruses 6 and 7, is commonly found in commercial pigs.
Denner, Joachim, Franzo, Giovanni, Hansen, Sabrina, Kaufer, Benedikt, Krabben, Ludwig, Marino, Stephen F., Menandro, Maria Luisa   +6 more
core   +1 more source

How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs. [PDF]

Xenotransplantation
ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Denner J, Jhelum H, Ban J, Krabben L, Kaufer BB.   +4 more
europepmc   +2 more sources

A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion [PDF]

, 2017
The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Beatrice Plougastel-Douglas, Daved H. Fremont, David Wang, Elvin J. Lauron, Eugene Park, Guoyan Zhao, Ian B. Harvey, Jennifer Poursine-Laurent, Swapneel J. Patel, Vinay R. Penna, Wandy L. Beatty, Wayne M. Yokoyama   +11 more
core   +2 more sources

The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses

Current Protocols, Volume 3, Issue 11, November 2023., 2023
Abstract Epitopes recognized by T cells are a collection of short peptide fragments derived from specific antigens or proteins. Immunological research to study T cell responses is hindered by the extreme degree of heterogeneity of epitope targets, which are usually derived from multiple antigens; within a given antigen, hundreds of different T cell ...
Ricardo da Silva Antunes, Daniela Weiskopf, John Sidney, Paul Rubiro, Bjoern Peters, Cecilia S. Lindestam Arlehamn, Alba Grifoni, Alessandro Sette   +7 more
wiley   +1 more source

Detection of human herpesvirus 6 and 7 DNA in saliva from healthy adults from Rio de Janeiro, Brazil

Memorias do Instituto Oswaldo Cruz, 2010
In this study, we aimed to evaluate virus shedding in the saliva of healthy adults from the metropolitan region of the city of Rio de Janeiro, Brazil, in order to verify the prevalence of both human herpesviruses 6 and 7 (HHV-6, HHV-7). The studied group
Ivna M Magalhães, Rebeca VN Martins, João J Cossatis, Renata M Cavaliere, Larissa A Afonso, Natalia Moysés, Solange A Oliveira, Silvia MB Cavalcanti   +7 more
doaj   +1 more source

Complementary Tumor Diagnosis by Single Cell–Based Cytogenetics Using Multi‐marker Fluorescence In Situ Hybridization (mFISH)

Current Protocols, Volume 3, Issue 11, November 2023., 2023
Abstract Multi‐color (or multi‐marker) fluorescence in situ hybridization (mFISH) is a well‐established, valuable, complementary tool for prenatal and pathological (tumor) diagnosis. A variety of chromosomal abnormalities, such as partial or total chromosomal gains, losses, inversions, or translocations, which are considered to cause genetic syndromes,
Gero Brockhoff
wiley   +1 more source

A Human Neuron/Astrocyte Co‐culture to Model Seeded and Spontaneous Intraneuronal Tau Aggregation

Current Protocols, Volume 3, Issue 10, October 2023., 2023
Abstract Communication and contact between neurons and astrocytes is important for proper brain physiology. How neuron/astrocyte crosstalk is affected by intraneuronal tau aggregation in neurodegenerative tauopathies is largely elusive. Human induced pluripotent stem cell (iPSC)‐derived neurons provide the opportunity to model tau pathology in a ...
Kevin Llewelyn Batenburg, Susan Karijn Rohde, Paulien Cornelissen‐Steijger, Nicole Breeuwsma, Vivi Majella Heine, Wiep Scheper   +5 more
wiley   +1 more source

A Primer for Research Scientists on Assessing Mouse Gross and Histopathology Images in the Biomedical Literature

Current Protocols, Volume 3, Issue 9, September 2023., 2023
Abstract Advances in genomic technologies have enabled the development of abundant mouse models of human disease, requiring accurate phenotyping to elucidate the consequences of genetic manipulation. Anatomic pathology, an important component of the mouse phenotyping pipeline, is ideally performed by human or veterinary pathologists; however, due to ...
Andrew J. Gifford
wiley   +1 more source