Results 21 to 30 of about 28,118 (222)
Sequence and analysis of the rpoB gene of Mycobacterium smegmatis [PDF]
Antimicrobial Agents and Chemotherapy, 1995 The rpoB gene encodes the beta subunit of the DNA-dependent RNA polymerase of bacteria. Mutations in defined areas result in resistance to rifampin. Mycobacterium smegmatis is naturally resistant to rifampin, but analysis of the rpoB gene revealed no identifiable rifampin resistance mutations. Another mechanism of resistance may be present.
S V, Hetherington +2 more
openaire +2 more sources
rpoB Mutations and Effects on Rifampin Resistance in Mycobacterium tuberculosis
Infection and Drug Resistance, 2021 To investigate the mutations within the whole rpoB gene of Mycobacterium tuberculosis and analyze their effects on rifampin (RIF) resistance based on crystal structure.We sequenced the entire rpoB gene in 175 tuberculosis isolates and quantified their minimum inhibitory concentrations using microplate-based assays.
Ma-chao Li +11 more
openaire +5 more sources
Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? [PDF]
, 2005 Introduction: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA.
O'Sullivan, DM +12 more
core +1 more source
Rifampicin resistance in tuberculosis outbreak, London, England [PDF]
, 2005 Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate.
Shorten, R J +20 more
core +1 more source
The rpoB gene as a tool for clinical microbiologists
Trends in Microbiology, 2009 The rpoB gene, encoding the beta-subunit of RNA polymerase, has emerged as a core gene candidate for phylogenetic analyses and identification of bacteria, especially when studying closely related isolates. Together with the 16S rRNA gene, rpoB has helped to delineate new bacterial species and refine bacterial community analysis, as well as enabling the
Adekambi, T. +2 more
openaire +3 more sources
, 2022 Tree expanding compressed clades in Fig 1C. ANME, anaerobic methanotrophic; GoM, Gulf of Mexico; RpoB, RNA polymerase subunit beta; (AI)
Danielle Goudeau (8455311) +16 more
core +1 more source
The Pan African Medical Journal, 2017 INTRODUCTION: Tuberculosis remains the leading causes of death worldwide with frequencies of mutations in rifampicin and isoniazid resistant Mycobacterium tuberculosis isolates varying according to geographical location.
Faustinos Tatenda Takawira +4 more
doaj +1 more source
Frontiers in Microbiology, 2020 Tuberculosis (TB) is an infectious respiratory disease caused by Mycobacterium tuberculosis and one of the top 10 causes of death worldwide. Treating TB is challenging; successful treatment requires a long course of multiple antibiotics. Rifampicin (RIF)
Li-Yin Lai +16 more
doaj +1 more source
Understanding Rifampicin Resistance in Tuberculosis through a Computational Approach [PDF]
Genomics & Informatics, 2014 The disease tuberculosis, caused by Mycobacterium tuberculosis (MTB), remains a major cause of morbidity and mortality in developing countries. The evolution of drug-resistant tuberculosis causes a foremost threat to global health.
Satish Kumar, Lingaraja Jena
doaj +1 more source
Origin and rpoB identification of workshop isolates.
, 2023 Origin and rpoB identification of workshop isolates.
L. Elaine Epperson (9250231) +11 more
core +1 more source