Results 11 to 20 of about 223,842 (291)

The nucleoid as a site of rRNA processing and ribosome assembly [PDF]

Frontiers in Plant Science, 2014
Protein biosynthesis is one of the key elements of gene expression in living cells. All proteins are synthesized on ribonucleoprotein complexes, the ribosomes. In bacteria and their derivatives—eukaryotic mitochondria and plastids—ribosomes consist of a small and a large subunit which together comprise more than 50 ribosomal proteins and usually two to
Alexandra-Viola eBohne
doaj   +5 more sources

Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing. [PDF]

RNA, 2022
In eukaryotes, the nucleolus is the site of ribosome biosynthesis, an essential process in all cells. While human ribosome assembly is largely evolutionarily conserved, many of the regulatory details underlying its control and function have not yet been well-defined.
McCool MA, Buhagiar AF, Bryant CJ, Ogawa LM, Abriola L, Surovtseva YV, Baserga SJ.   +6 more
europepmc   +3 more sources

RECQ5 mediates pre-rRNA processing in nucleolus. [PDF]

Nucleic Acids Res
Abstract RECQ5 is a member of the RECQ helicase family that maintains genomic stability. However, the molecular mechanism of RECQ5 in this biological process remains elusive. Here, we show that RECQ5 localizes in the dense fibrillar component of nucleolus and associates with several pre-rRNA processing factors. It recognizes pre-rRNA and
Ma Y, Yu X.
europepmc   +3 more sources

The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis

BMC Plant Biology, 2023
Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek, Anna Golisz-Mocydlarz, Michal Krzyszton, Justyna Piotrowska, Malgorzata Lichocka, Joanna Kufel   +5 more
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Effects of Hydrogen Peroxide Stress on the Nucleolar Redox Environment and Pre-rRNA Maturation

Frontiers in Molecular Biosciences, 2021
Identifying biologically relevant molecular targets of oxidative stress may provide new insights into disease mechanisms and accelerate development of novel biomarkers. Ribosome biogenesis is a fundamental prerequisite for cellular protein synthesis, but
Russell T. Sapio, Russell T. Sapio, Chelsea J. Burns, Dimitri G. Pestov   +3 more
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The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression

Nature Communications, 2023
Transcription by RNA polymerase I (RNAPI) represents most of the transcriptional activity in eukaryotic cells and is associated with the production of mature ribosomal RNA (rRNA).
Maxime Duval, Carlo Yague-Sanz, Tomasz W. Turowski, Elisabeth Petfalski, David Tollervey, François Bachand   +5 more
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rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans

Cell Reports, 2023
Summary: The nucleolus is the most prominent membraneless organelle within the nucleus. How the nucleolar structure is regulated is poorly understood. Here, we identified two types of nucleoli in C. elegans.
Demin Xu, Xiangyang Chen, Yan Kuang, Minjie Hong, Ting Xu, Ke Wang, Xinya Huang, Chuanhai Fu, Ke Ruan, Chengming Zhu, Xuezhu Feng, Shouhong Guang   +11 more
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WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals. [PDF]

Nucleic Acids Res
Abstract Mitochondrial rRNAs play important roles in regulating mtDNA-encoded gene expression and energy metabolism subsequently. However, the proteins that regulate mitochondrial 16S rRNA processing remain poorly understood. Herein, we generated adipose-specific Wbscr16-/-mice and cells, both of which exhibited dramatic mitochondrial ...
Zhang S, Dong Z, Feng Y, Guo W, Zhang C, Shi Y, Zhao Z, Wang J, Ning G, Huang G.   +9 more
europepmc   +3 more sources

Coordinated Control of rRNA Processing by RNA Polymerase I. [PDF]

Trends Genet, 2019
Ribosomal RNA (rRNA) is co- and post-transcriptionally processed into active ribosomes. This process is dynamically regulated by direct covalent modifications of the polymerase that synthesizes the rRNA, RNA polymerase I (Pol I), and by interactions with cofactors that influence initiation, elongation, and termination activities of Pol I.
Scull CE, Schneider DA.
europepmc   +4 more sources

Modification of Adenosine196 by Mettl3 Methyltransferase in the 5’-External Transcribed Spacer of 47S Pre-rRNA Affects rRNA Maturation

Cells, 2020
Ribosome biogenesis is among the founding processes in the cell. During the first stages of ribosome biogenesis, polycistronic precursor of ribosomal RNA passes complex multistage maturation after transcription.
Olga Sergeeva, Philipp Sergeev, Pavel Melnikov, Tatiana Prikazchikova, Olga Dontsova, Timofei Zatsepin   +5 more
doaj   +1 more source