Results 11 to 20 of about 136,829 (254)

WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals. [PDF]

Nucleic Acids Res
Abstract Mitochondrial rRNAs play important roles in regulating mtDNA-encoded gene expression and energy metabolism subsequently. However, the proteins that regulate mitochondrial 16S rRNA processing remain poorly understood. Herein, we generated adipose-specific Wbscr16-/-mice and cells, both of which exhibited dramatic mitochondrial ...
Zhang S, Dong Z, Feng Y, Guo W, Zhang C, Shi Y, Zhao Z, Wang J, Ning G, Huang G.   +9 more
europepmc   +3 more sources

BMAL1 Associates with NOP58 in the Nucleolus and Contributes to Pre-rRNA Processing [PDF]

iScience, 2020
Summary: The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II.
Marlene Cervantes, Ignasi Forné, Suman Ranjit, Enrico Gratton, Axel Imhof, Paolo Sassone-Corsi   +5 more
doaj   +2 more sources

Knock-Down of a Novel snoRNA in Tetrahymena Reveals a Dual Role in 5.8S rRNA Processing and Generation of a 26S rRNA Fragment [PDF]

Biomolecules, 2018
In eukaryotes, 18S, 5.8S, and 28S rRNAs are transcribed as precursor molecules that undergo extensive modification and nucleolytic processing to form the mature rRNA species. Central in the process are the small nucleolar RNAs (snoRNAs).
Kasper L. Andersen, Henrik Nielsen
doaj   +2 more sources

Modular RNA:DNA Nanostructures Enable Nanopore Profiling of rRNA Processing and rRNA Variants. [PDF]

ACS Nano
Boskovic F, Sandler SE, Brauburger S, Shui Y, Kumar B, Dias JP, Naydenova P, Zhu J, Baker S, Keyser UF.   +9 more
europepmc   +2 more sources

Endonucleolytic processing plays a critical role in the maturation of ribosomal RNA in Methanococcus maripaludis

RNA Biology, 2023
Ribosomal RNA (rRNA) processing and maturation are fundamentally important for ribosome biogenesis, but the mechanisms in archaea, the third form of life, remains largely elusive.
Lei Qi, Huan Liu, Jian Gao, Kai Deng, Xiaoyan Wang, Xiuzhu Dong, Jie Li   +6 more
doaj   +1 more source

Upon heat stress processing of ribosomal RNA precursors into mature rRNAs is compromised after cleavage at primary P site in Arabidopsis thaliana

RNA Biology, 2022
Transcription and processing of 45S rRNAs in the nucleolus are keystones of ribosome biogenesis. While these processes are severely impacted by stress conditions in multiple species, primarily upon heat exposure, we lack information about the molecular ...
T. Darriere, E. Jobet, D. Zavala, M.L. Escande, N. Durut, A. de Bures, F. Blanco-Herrera, E.A. Vidal, M. Rompais, C. Carapito, S. Gourbiere, J. Sáez-Vásquez   +11 more
doaj   +1 more source

The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis

BMC Plant Biology, 2023
Background NOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The most well-described yeast counterpart, Rrp17, is required for maturation of 5.8 and 25S rRNAs, whereas ...
Monika Zakrzewska-Placzek, Anna Golisz-Mocydlarz, Michal Krzyszton, Justyna Piotrowska, Malgorzata Lichocka, Joanna Kufel   +5 more
doaj   +1 more source

rRNA intermediates coordinate the formation of nucleolar vacuoles in C. elegans

Cell Reports, 2023
Summary: The nucleolus is the most prominent membraneless organelle within the nucleus. How the nucleolar structure is regulated is poorly understood. Here, we identified two types of nucleoli in C. elegans.
Demin Xu, Xiangyang Chen, Yan Kuang, Minjie Hong, Ting Xu, Ke Wang, Xinya Huang, Chuanhai Fu, Ke Ruan, Chengming Zhu, Xuezhu Feng, Shouhong Guang   +11 more
doaj   +1 more source

The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression

Nature Communications, 2023
Transcription by RNA polymerase I (RNAPI) represents most of the transcriptional activity in eukaryotic cells and is associated with the production of mature ribosomal RNA (rRNA).
Maxime Duval, Carlo Yague-Sanz, Tomasz W. Turowski, Elisabeth Petfalski, David Tollervey, François Bachand   +5 more
doaj   +1 more source

Effects of Hydrogen Peroxide Stress on the Nucleolar Redox Environment and Pre-rRNA Maturation

Frontiers in Molecular Biosciences, 2021
Identifying biologically relevant molecular targets of oxidative stress may provide new insights into disease mechanisms and accelerate development of novel biomarkers. Ribosome biogenesis is a fundamental prerequisite for cellular protein synthesis, but
Russell T. Sapio, Russell T. Sapio, Chelsea J. Burns, Dimitri G. Pestov   +3 more
doaj   +1 more source