Results 21 to 30 of about 3,138,640 (295)

WBSCR16 is essential for mitochondrial 16S rRNA processing in mammals. [PDF]

Nucleic Acids Res
Abstract Mitochondrial rRNAs play important roles in regulating mtDNA-encoded gene expression and energy metabolism subsequently. However, the proteins that regulate mitochondrial 16S rRNA processing remain poorly understood. Herein, we generated adipose-specific Wbscr16-/-mice and cells, both of which exhibited dramatic mitochondrial ...
Zhang S, Dong Z, Feng Y, Guo W, Zhang C, Shi Y, Zhao Z, Wang J, Ning G, Huang G.   +9 more
europepmc   +3 more sources

Plant specificities in rRNA processing : from snoRNA to rRNA variations

, 2023
The production of ribosomes is a complicated multistep, that is susceptible to changes occurring within the cell and its environment. The process itself requires many proteins, known as ribosome biogenesis factors (RBFs) and many non-coding RNAs like the small nucleolar RNAs (snoRNAs). While RBFs are required for the accurate processing of the pre-rRNA
Streit, Deniz
openaire   +3 more sources

Yeast Pre-rRNA Processing and Modification Occur Cotranscriptionally [PDF]

Molecular Cell, 2010
To better understand yeast ribosome synthesis, we developed techniques for the rapid harvesting and analysis of metabolically labeled cultures. Modeling of the resulting kinetic data allowed predicted lifetimes and processing patterns to be compared with the experimental data.
Kos, Martin, Tollervey, David
openaire   +4 more sources

A Mutant Era GTPase Suppresses Phenotypes Caused by Loss of Highly Conserved YbeY Protein in Escherichia coli

Frontiers in Microbiology, 2022
Ribosome assembly is a complex fundamental cellular process that involves assembling multiple ribosomal proteins and several ribosomal RNA species in a highly coordinated yet flexible and resilient manner.
Vignesh M. P. Babu, Siva Sankari, Anubrata Ghosal, Graham C. Walker   +3 more
doaj   +1 more source

Duration of the first steps of the human rRNA processing [PDF]

Nucleus, 2013
Processing of rRNA in mammalian cells includes a series of cleavages of the primary 47S transcript and results in producing three rRNAs: 18S, 28S and 5.8S. The sequence of the main processing events in human cells has been established, but little is yet known about the dynamics of this process, especially the dynamics of its early stages.
Alexey, Popov, Evgeny, Smirnov, Lubomír, Kováčik, Otakar, Raška, Guy, Hagen, Lenka, Stixová, Ivan, Raška   +6 more
openaire   +2 more sources

Splicing Endonuclease Is an Important Player in rRNA and tRNA Maturation in Archaea

Frontiers in Microbiology, 2020
In all three domains of life, tRNA genes contain introns that must be removed to yield functional tRNA. In archaea and eukarya, the first step of this process is catalyzed by a splicing endonuclease.
Thandi S. Schwarz, Sarah J. Berkemer, Sarah J. Berkemer, Sarah J. Berkemer, Stephan H. Bernhart, Stephan H. Bernhart, Matthias Weiß, Sébastien Ferreira-Cerca, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Anita Marchfelder   +17 more
doaj   +1 more source

The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. [PDF]

PLoS ONE, 2011
NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are exported to the cytoplasm.
Luis G Morello, Patricia P Coltri, Alexandre J C Quaresma, Fernando M Simabuco, Tereza C L Silva, Guramrit Singh, Jeffrey A Nickerson, Carla C Oliveira, Melissa J Moore, Nilson I T Zanchin   +9 more
doaj   +1 more source

RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control

Biomolecules, 2021
RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified RNA substrates and thereby ...
Lisa Lirussi, Özlem Demir, Panpan You, Antonio Sarno, Rommie E. Amaro, Hilde Nilsen   +5 more
doaj   +1 more source

Critical Role of Nucleostemin in Pre-rRNA Processing [PDF]

Journal of Biological Chemistry, 2009
Nucleostemin is a nucleolar protein widely expressed in proliferating cells. Nucleostemin is involved in the regulation of cell proliferation, and both depletion and overexpression of nucleostemin induce cell cycle arrest through the p53 signaling pathway. Although the presence of p53-independent functions of nucleostemin has been previously suggested,
Liudmila, Romanova, Anthony, Grand, Liying, Zhang, Samuel, Rayner, Nobuko, Katoku-Kikyo, Steven, Kellner, Nobuaki, Kikyo   +6 more
openaire   +2 more sources

Reconstruction of small subunit ribosomal RNA from high‐throughput sequencing data: A comparative study of metagenomics and total RNA sequencing

Methods in Ecology and Evolution, 2023
The small subunit (SSU) ribosomal RNA (rRNA) is the most commonly used marker for the identification of microbial taxa, but its full‐length reconstruction from high‐throughput sequencing (HTS) data remains challenging.
Christopher A. Hempel, Shea E. E. Carson, Tyler A. Elliott, Sarah J. Adamowicz, Dirk Steinke   +4 more
doaj   +1 more source