Results 21 to 30 of about 223,842 (291)

A Mutant Era GTPase Suppresses Phenotypes Caused by Loss of Highly Conserved YbeY Protein in Escherichia coli

Frontiers in Microbiology, 2022
Ribosome assembly is a complex fundamental cellular process that involves assembling multiple ribosomal proteins and several ribosomal RNA species in a highly coordinated yet flexible and resilient manner.
Vignesh M. P. Babu, Siva Sankari, Anubrata Ghosal, Graham C. Walker   +3 more
doaj   +1 more source

Splicing Endonuclease Is an Important Player in rRNA and tRNA Maturation in Archaea

Frontiers in Microbiology, 2020
In all three domains of life, tRNA genes contain introns that must be removed to yield functional tRNA. In archaea and eukarya, the first step of this process is catalyzed by a splicing endonuclease.
Thandi S. Schwarz, Sarah J. Berkemer, Sarah J. Berkemer, Sarah J. Berkemer, Stephan H. Bernhart, Stephan H. Bernhart, Matthias Weiß, Sébastien Ferreira-Cerca, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Peter F. Stadler, Anita Marchfelder   +17 more
doaj   +1 more source

Critical Role of Nucleostemin in Pre-rRNA Processing [PDF]

Journal of Biological Chemistry, 2009
Nucleostemin is a nucleolar protein widely expressed in proliferating cells. Nucleostemin is involved in the regulation of cell proliferation, and both depletion and overexpression of nucleostemin induce cell cycle arrest through the p53 signaling pathway. Although the presence of p53-independent functions of nucleostemin has been previously suggested,
Liudmila, Romanova, Anthony, Grand, Liying, Zhang, Samuel, Rayner, Nobuko, Katoku-Kikyo, Steven, Kellner, Nobuaki, Kikyo   +6 more
openaire   +2 more sources

The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. [PDF]

PLoS ONE, 2011
NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are exported to the cytoplasm.
Luis G Morello, Patricia P Coltri, Alexandre J C Quaresma, Fernando M Simabuco, Tereza C L Silva, Guramrit Singh, Jeffrey A Nickerson, Carla C Oliveira, Melissa J Moore, Nilson I T Zanchin   +9 more
doaj   +1 more source

RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control

Biomolecules, 2021
RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified RNA substrates and thereby ...
Lisa Lirussi, Özlem Demir, Panpan You, Antonio Sarno, Rommie E. Amaro, Hilde Nilsen   +5 more
doaj   +1 more source

Accurate Processing of Human Pre-rRNA In Vitro [PDF]

Molecular and Cellular Biology, 1989
We report here that the mature 5' terminus of human 18S rRNA is generated in vitro by a two-step processing reaction. In the first step, SP6 transcripts were specifically cleaved in HeLa cell nucleolar extract at three positions near the external transcribed spacer (ETS)-18S boundary.
G J, Hannon, P A, Maroney, A, Branch, B J, Benenfield, H D, Robertson, T W, Nilsen   +5 more
openaire   +2 more sources

Reconstruction of small subunit ribosomal RNA from high‐throughput sequencing data: A comparative study of metagenomics and total RNA sequencing

Methods in Ecology and Evolution, 2023
The small subunit (SSU) ribosomal RNA (rRNA) is the most commonly used marker for the identification of microbial taxa, but its full‐length reconstruction from high‐throughput sequencing (HTS) data remains challenging.
Christopher A. Hempel, Shea E. E. Carson, Tyler A. Elliott, Sarah J. Adamowicz, Dirk Steinke   +4 more
doaj   +1 more source

Ribonucleoproteins in archaeal pre-rRNA processing and modification. [PDF]

Archaea, 2013
Given that ribosomes are one of the most important cellular macromolecular machines, it is not surprising that there is intensive research in ribosome biogenesis. Ribosome biogenesis is a complex process. The maturation of ribosomal RNAs (rRNAs) requires not only the precise cleaving and folding of the pre-rRNA but also extensive nucleotide ...
Yip WS, Vincent NG, Baserga SJ.
europepmc   +4 more sources

Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors [PDF]

, 2014
Ribosome biogenesis is a key process for maintaining protein synthetic capacity in dividing or growing cells, and requires coordinated production of ribosomal proteins and ribosomal RNA (rRNA), including the processing of the latter.
Arora, Baird, Beugnet, Boultwood, Brandenburger, Brenneisen, Browne, Chresta, Christopher G. Proud, Dong, Drygin, Dunlop, Feldman, Fonseca, Fonseca, Fumagalli, Gingras, Grimm, Hannan, Hara, Holzel, Horn, Horos, Huang, Iadevaia, Iadevaia, Jastrzebski, Jefferies, Julien Averous, Killian, Kimball, Kispal, Lam, Le-Bacquer, Lempiainen, Lempiainen, Loreni, Mayer, Mayer, Meyuhas, Miluzio, Montanaro, Oshiro, Patursky-Polischuk, Pearce, Pearson, Peter M. Taylor, Pianese, Popowski, Proud, Redpath, Rodnina, Rohrmoser, Rui Liu, Sancak, Sancak, Sanchez, Sarbassov, Smith, Strezoska, Strezoska, Thoreen, Valentina Iadevaia, Wang, Wang, Willett, Xiao, Yip, Ze Zhang   +68 more
core   +6 more sources

Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli [PDF]

The Journal of Antibiotics, 2019
In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking the mature rRNAs, and not necessarily by the nucleotide sequences.
Chukwudi, C U, Good, L
openaire   +2 more sources