Viruses, 2022 The nucleolus is a subnuclear compartment whose primary function is the biogenesis of ribosomal subunits. Certain viral infections affect the morphology and composition of the nucleolar compartment and influence ribosomal RNA (rRNA) transcription and ...
Nofar Atari +9 more
doaj +1 more source
Development and field assessment of a quantitative PCR for the detection and enumeration of the noxious bloom-former Anabaena planktonica [PDF]
, 2007 Anabaena planktonica is a harmful, bloom-forming freshwater cyanobacterium, which has arrived recently in New Zealand. In the short time since its incursion (
Cary, S. Craig +2 more
core +1 more source
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
core +2 more sources
Small Nucleolar RNAs and Pre-rRNA Processing in Plants [PDF]
The Plant Cell, 1998 Messenger RNA (mRNA) translation and thereby gene expression depend on the cell's ability to produce vast numbers of ribosomes, the major component of the translational machinery. The complexity inherent in the production of ribosomal RNAs (rRNAs), the key RNA components of the ribosome ...
J W, Brown, P J, Shaw
openaire +2 more sources
The Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome-associated Human Mitochondrial tRNALeu(UUR) Mutation Causes Aminoacylation Deficiency and Concomitant Reduced Association of mRNA with Ribosomes [PDF]
, 2000 The pathogenetic mechanism of the mitochondrial tRNALeu(UUR) A3243G transition associated with the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome has been investigated in transmitochondrial cell lines ...
Attardi, Giuseppe +4 more
core +1 more source
Highly efficient RNA-synthesizing system that uses isolated human mitochondria: new initiation events and in vivo-like processing patterns [PDF]
, 1984 A highly efficient RNA-synthesizing system with isolated HeLa cell mitochondria has been developed and characterized regarding its requirements and its products.
Attardi, Giuseppe, Gaines, George
core
Quantitative analysis of snoRNA association with pre-ribosomes and release of snR30 by Rok1 helicase [PDF]
, 2008 In yeast, three small nucleolar RNAs (snoRNAs) are essential for the processing of pre-ribosomal RNA—U3, U14 and snR30—whereas 72 non-essential snoRNAs direct site-specific modification of pre-rRNA. We applied a quantitative screen for alterations in the
Bohnsack, Markus +2 more
core +2 more sources
Yeast Pre-rRNA Processing and Modification Occur Cotranscriptionally [PDF]
Molecular Cell, 2010 To better understand yeast ribosome synthesis, we developed techniques for the rapid harvesting and analysis of metabolically labeled cultures. Modeling of the resulting kinetic data allowed predicted lifetimes and processing patterns to be compared with the experimental data.
Kos, Martin, Tollervey, David
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Quantitative Detection of Syntrophic Fatty Acid-degrading Bacterial Communities in Methanogenic Environments [PDF]
, 2015 In methanogenic habitats, volatile fatty acids (VFA), such as propionate and butyrate, are major intermediates in organic matter degradation. VFA are further metabolized to H2, acetate and CO2 by syntrophic fatty acid-degrading bacteria (SFAB) in ...
Maki, James +2 more
core +2 more sources