Results 31 to 40 of about 257 (91)

Role of peroxisome proliferator‐activated receptor gamma gene polymorphisms in type 2 diabetes mellitus patients of West Bengal, India

Journal of Diabetes Investigation, Volume 5, Issue 2, Page 188-191, March 2014., 2014
Abstract Aims/Introduction Peroxisome proliferator activated receptor gamma (PPARG) is a nuclear hormone receptor of the ligand‐dependent transcription factor involved in adipogenesis, and a molecular target of the insulin sensitizer, thiazolidinediones.
Arup Kumar Pattanayak, Biswabandhu Bankura, Nisha Balmiki, Tapas Kumar Das, Subhankar Chowdhury, Madhusudan Das   +5 more
wiley   +1 more source

Metabolic biomarkers in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction

Сахарный диабет
BACKGROUND: Half of all patients with chronic heart failure (CHF) have preserved ejection fraction (CHF-nEF). The drug’s use effective for treatment of CHF with reduced ejection fraction (CHF-nFV) reduces the hospitalization incidence but does not affect
T. S. Sveklina, S. B. Shustov, S. N. Kolyubayeva, A. N. Kuchmin, V. A. Kozlov, E. V. Smirnova, A. V. Zharkov   +6 more
doaj   +1 more source

Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia

Dementia and Geriatric Cognitive Disorders Extra, 2013
Background and Aims: Similar clinical and pathological features have been observed in Alzheimer's disease (AD) and Parkinson's disease with dementia (PDD).
Nobuto Shibata, Yumiko Motoi, Hiroyuki Tomiyama, Tohru Ohnuma, Bolati Kuerban, Katrin Tomson, Miwa Komatsu, Hiromi Shimazaki, Nobutaka Hattori, Heii Arai   +9 more
doaj   +1 more source

Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross‐Sectional Data from the J‐MICC Study

PPAR Research, Volume 2013, Issue 1, 2013., 2013
Chronic kidney disease (CKD) is well known as a strong risk factor for both end stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the PPAR genes (PPARD, PPARG, and PPARGC1A) with the risk of CKD in Japanese, we examined this association among the Japanese subjects using the cross‐sectional data of J‐MICC ...
Asahi Hishida, Kenji Wakai, Mariko Naito, Takashi Tamura, Sayo Kawai, Nobuyuki Hamajima, Isao Oze, Takeshi Imaizumi, Tanvir Chowdhury Turin, Sadao Suzuki, Motahare Kheradmand, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka, Constantinos Giaginis   +17 more
wiley   +1 more source

The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course

PPAR Research, Volume 2012, Issue 1, 2012., 2012
PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurring PPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison
Jessica Mwinyi, Christa Grete-Wenger, Jyrki J. Eloranta, Gerd A. Kullak-Ublick, Ruth Roberts   +4 more
wiley   +1 more source

Association of PPARG gene variants with obesity in South Indian young adults: a cross-sectional study

BMJ Connections Clinical Genetics and Genomics
Introduction Peroxisome proliferator-activated receptor gamma (PPARG) gene polymorphisms, particularly rs1801282 (Pro12Ala) and rs3856806 (C161T), have been implicated in obesity, but findings remain inconsistent across populations.
Shobha C Ramachandra, Cylvia Alphones Luke Jeeva Amala Rani, Raveen Nagaraje Gowda, Vaibhavishree Muniswamy, Anju Srinivas   +4 more
doaj   +1 more source

Genetic Variability of RXRB, PPARA, and PPARG in Wegener′s Granulomatosis

PPAR Research, Volume 2009, Issue 1, 2009., 2009
A major genomic region involved in Wegener′s granulomatosis includes the gene for retinoid receptor beta (RXRB) which forms heterodimers with peroxisome proliferator‐activated receptors (PPARs). It is unclear whether this association directly arises from the RXRB allele(s) or via a linked variation.
Stefan Wieczorek, Silvia Knaup, Wolfgang L. Gross, Jörg T. Epplen, Mostafa Badr   +4 more
wiley   +1 more source

PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease

PPAR Research, Volume 2008, Issue 1, 2008., 2008
The peroxisome proliferator‐activated receptors (PPARs) consist of three related transcription factors that serve to regulate a number of cellular processes that are central to cardiovascular health and disease. Numerous pharmacologic studies have assessed the effects of specific PPAR agonists in clinical trials and have provided insight into the ...
Sharon Cresci, Giulia Chinetti
wiley   +1 more source

The Genetics of PPARG and the Skeleton

PPAR Research, Volume 2006, Issue 1, 2006., 2006
Osteoporosis is a complex metabolic bone disorder. Recently it has been appreciated that the “obesity in bone” phenomenon occurs at the expense of bone formation, and that is a key component of the pathology of this disease. Mouse models with altered bone expression levels of peroxisome proliferator‐activated receptor gamma (PPARG) impact bone ...
Cheryl Ackert-Bicknell, Clifford Rosen
wiley   +1 more source

Effects of the PPARG gene polymorphisms on markers of obesity and the metabolic syndrome in Bosnian subjects [PDF]

Journal of Medical Biochemistry, 2014
Background: Peroxisome proliferator-activated receptor gamma (PPARg) is a key transcription factor in adipogenesis, and also regulates a number of genes associated with lipid storage and insulin sensitivity.
Dujić Tanja, Bego Tamer, Mlinar Barbara, Semiz Sabina, Malenica Maja, Prnjavorac Besim, Ostanek Barbara, Marc Janja, Čaušević Adlija   +8 more
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