Results 21 to 30 of about 257 (91)

Identification of RNA‐Binding Proteins with Prognostic Prediction in Colorectal Cancer

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Colorectal cancer (CRC) is one of the most common malignancies of the digestive system. Recent studies have revealed the importance of RNA‐binding proteins (RBPs) in tumorigenesis, but their role in CRC remains unclear. The present study systematically analyzed the relationships between RBPs and CRC using data from The Cancer Genome Atlas.
Xiao-fen Bai, Jing-wen Liu, Nagarajan Raju   +2 more
wiley   +1 more source

Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population [PDF]

Diabetology and Metabolic Syndrome, 2017
Qing Gu, Xiaohui Lv, Sun Jiayu
exaly   +2 more sources

Association of Peroxisome Proliferator‐Activated Receptors (PPARs) with Diabetic Retinopathy in Human and Animal Models: Analysis of the Literature and Genome Browsers

PPAR Research, Volume 2020, Issue 1, 2020., 2020
Diabetic retinopathy (DR) is a condition that develops after long‐lasting and poorly handled diabetes and is presently the main reason for blindness among elderly and youth. Peroxisome proliferator‐activated receptors (PPARs) are nuclear receptors that are involved in carbohydrate and fatty‐acid metabolism and have also been associated with DR.
Špela Tajnšek, Danijel Petrovič, Mojca Globočnik Petrovič, Tanja Kunej, John P. Vanden Heuvel   +4 more
wiley   +1 more source

Analysis of the haplotype and linkage disequilibrium of PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 among patients with metabolic syndrome in Kazakh of Xinjiang Province

Genetics and Molecular Research, 2014
We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients
S X, Guo, H, Guo, R L, Ma, Y S, Ding, J Y, Zhang, J M, Liu, M, Zhang, Q, Niu, N, Qiang, S G, Li, C N, Qi   +10 more
openaire   +2 more sources

Gene‐lifestyle interaction on risk of type 2 diabetes: A systematic review

Obesity Reviews, Volume 20, Issue 11, Page 1557-1571, November 2019., 2019
Summary The pathophysiological influence of gene‐lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene‐lifestyle interactions regarding T2D incidence.
Stefan Dietrich, Simone Jacobs, Ju‐Sheng Zheng, Karina Meidtner, Lukas Schwingshackl, Matthias B. Schulze   +5 more
wiley   +1 more source

Peroxisome Proliferator‐Activated Receptors Associated with Nonalcoholic Fatty Liver Disease

PPAR Research, Volume 2017, Issue 1, 2017., 2017
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming a major cause of chronic liver disease worldwide. Concurrent to an increase in NAFLD prevalence, there is an increase in the obesity epidemic and the correlated insulin‐resistant state. It is a challenge to diagnose NAFLD because many patients are asymptomatic until the later stages of ...
Nan Wang, Rui Kong, Hui Luo, Xiaorong Xu, Jie Lu, Yuewen Gong   +5 more
wiley   +1 more source

Association of PPAR Alpha Intron 7 G/C, PPAR Gamma 2 Pro12Ala, and C161T Polymorphisms with Serum Fetuin‐A Concentrations

PPAR Research, Volume 2017, Issue 1, 2017., 2017
Background. Both peroxisome activator proteins (PPARs) and fetuin‐A play a role in lipid and glucose metabolism. Aims. We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin‐A concentrations. Patients and Methods.
Bernadett Márkus, Krisztián Vörös, Dorina Supák, Zsolt Melczer, Károly Cseh, László Kalabay, Marcin Baranowski   +6 more
wiley   +1 more source

Interplay between Superoxide Dismutase, Glutathione Peroxidase, and Peroxisome Proliferator Activated Receptor Gamma Polymorphisms on the Risk of End‐Stage Renal Disease among Han Chinese Patients

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Background. Single nucleotide polymorphisms (SNPs) of antioxidants, including superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an important role in the risk for cancer and metabolic disorders. However, little is known regarding the effect of antioxidant SNPs on renal events. Methods. We prospectively enrolled multicenter patients
Chia-Ter Chao, Yen-Ching Chen, Chih-Kang Chiang, Jenq-Wen Huang, Cheng-Chung Fang, Chen-Chih Chang, Chung-Jen Yen, Ada Popolo   +7 more
wiley   +1 more source

Association of the variants in the PPARG gene and serum lipid levels: a meta‐analysis of 74 studies

Journal of Cellular and Molecular Medicine, Volume 19, Issue 1, Page 198-209, January 2015., 2015
Abstract Considerable studies have been carried out to investigate the relationship between the polymorphisms of PPARG (Pro12Ala, C161T and C1431T) and serum lipid levels, but the results were inconclusive. Hence, we conducted a meta‐analysis to clarify the association.
Qing Li, Rong Chen, Lizhan Bie, Dandan Zhao, Chunkai Huang, Jiang Hong   +5 more
wiley   +1 more source

Sequence Variants of Peroxisome Proliferator‐Activated Receptor‐Gamma Gene and the Clinical Courses of Patients with End‐Stage Renal Disease

Disease Markers, Volume 2015, Issue 1, 2015., 2015
Background. PPAR‐γ single nucleotide polymorphisms (SNPs) reportedly play an important role in determining metabolic risk among diverse population. Whether PPAR‐γ SNPs affect the clinical courses in ESRD patients is unknown. Methods. From a multicenter cohort, we identified 698 patients with prevalent ESRD between 2002 and 2003, and other 782 healthy ...
Chia-Ter Chao, Yen-Ching Chen, Chih-Kang Chiang, Jenq-Wen Huang, Fu-Chang Hu, Cheng-Chung Fang, Chen-Chih Chang, Chung-Jen Yen, Gad Rennert   +8 more
wiley   +1 more source