Results 61 to 70 of about 22,830,963 (211)

Positive Regulation of the Antiviral Activity of Interferon-Induced Transmembrane Protein 3 by S-Palmitoylation

Frontiers in Immunology, 2022
The interferon-induced transmembrane protein 3 (IFITM3), a small molecule transmembrane protein induced by interferon, is generally conserved in vertebrates, which can inhibit infection by a diverse range of pathogenic viruses such as influenza virus ...
Shubo Wen, Shubo Wen, Yang Song, Yang Song, Chang Li, Ningyi Jin, Jingbo Zhai, Jingbo Zhai, Huijun Lu   +8 more
doaj   +1 more source

SwissPalm: Protein Palmitoylation database [v1; ref status: indexed, http://f1000r.es/5co]

F1000Research, 2015
Protein S-palmitoylation is a reversible post-translational modification that regulates many key biological processes, although the full extent and functions of protein S-palmitoylation remain largely unexplored.
Mathieu Blanc, Fabrice David, Laurence Abrami, Daniel Migliozzi, Florence Armand, Jérôme Bürgi, Françoise Gisou van der Goot   +6 more
doaj   +1 more source

Palmitoylation of Plasmodium alveolins promotes cytoskeletal function. [PDF]

, 2017
S-palmitoylation is a post-translational lipid modification that is widespread among Plasmodium proteins and essential for parasite development. Little is known about the contribution of palmitoylation to the function of individual parasite molecules and
Al-Khattaf, Fatimah S, Dessens, Johannes T, Tremp, Annie Z   +2 more
core   +1 more source

Protein Lipidation by Palmitate Controls Macrophage Function

Cells, 2022
Macrophages are present in all tissues within our body, where they promote tissue homeostasis by responding to microenvironmental triggers, not only through clearance of pathogens and apoptotic cells but also via trophic, regulatory, and repair functions.
Jeroen Guns, Sam Vanherle, Jerome J. A. Hendriks, Jeroen F. J. Bogie   +3 more
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

Membrane-associated proteins in giardia lamblia [PDF]

, 2018
The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza, Ropolo, Andrea Silvana, Touz, Maria Carolina   +2 more
core   +1 more source

S-Palmitoylation and S-Oleoylation of Rabbit and Pig Sarcolipin [PDF]

Journal of Biological Chemistry, 2014
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and, surprisingly, an oleic acid in the remaining 40%. SLN used for co-crystallization with SERCA1a (Winther, A.
Montigny, Cédric, Decottignies, Paulette, Le Maréchal, Pierre, Capy, Pierre, Bublitz, Maike, Olesen, Claus, Møller, Jesper Vuust, Nissen, Poul, Le Maire, Marc   +8 more
openaire   +2 more sources

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

MDD-Palm: Identification of protein S-palmitoylation sites with substrate motifs based on maximal dependence decomposition.

PLoS ONE, 2017
S-palmitoylation, the covalent attachment of 16-carbon palmitic acids to a cysteine residue via a thioester linkage, is an important reversible lipid modification that plays a regulatory role in a variety of physiological and biological processes. As the
Shun-Long Weng, Hui-Ju Kao, Chien-Hsun Huang, Tzong-Yi Lee   +3 more
doaj   +1 more source

Evolutionarily Established Palmitoylation-Dependent Regulatory Mechanisms of the Vertebrate Glutamatergic Synapse and Diseases Caused by Their Disruption

Frontiers in Molecular Neuroscience, 2021
Glutamate is the major excitatory neurotransmitter in the vertebrate brain and various modifications have been established in the glutamatergic synapses.
Takashi Hayashi
doaj   +1 more source