Results 11 to 20 of about 26,395 (209)

Saccharin Aggravates Eosinophilic Esophagitis via MAPK3 Interaction: A Network Toxicology and Machine Learning Study With SPR Analysis. [PDF]

Food Sci Nutr
This study provides a novel molecular perspective on the role of dietary factors in EoE pathogenesis. We establish saccharin as a key aggravating factor for EoE and highlight MAPK3 as a compelling therapeutic target. Our findings suggest that controlling saccharin intake represents a direct and beneficial dietary management strategy for EoE.
Yang Y, Guo T, Li P, Gao K, Ning X, Zhou L, Zhou W, Zeng B.   +7 more
europepmc   +2 more sources

Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste Receptor-Induced Activation of PLC Signaling Axis

Biomedicines, 2022
Background: Saccharin is a common artificial sweetener and a bona fide ligand for sweet taste receptors (STR). STR can regulate insulin secretion in beta cells, so we investigated whether saccharin can stimulate insulin secretion dependent on STR and the
Joan Serrano, Nishita N. Meshram, Mangala M. Soundarapandian, Kathleen R. Smith, Carter Mason, Ian S. Brown, Björn Tyrberg, George A. Kyriazis   +7 more
doaj   +1 more source

Menthol-like cooling compounds, including (R)-(-)-carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K. [PDF]

FEBS Open Bio
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Saito M, Misaka T.
europepmc   +2 more sources

Effects of ethanolic fruit extract of solanum aethiopicum (L.) on saccharin induced hyperlipidemia and sperm abnormalities in male wistar rats [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Saccharin is approximately 300 times sweeter than sucrose, and since its discovery, there has been several controversies regarding its potential toxicity as chronic saccharin consumption negatively influences biochemical parameters ...
Mishael Atukpa, Aruchi Wekhe, Al-amin Idris, Richard Recab   +3 more
doaj  

Saccharinity [PDF]

The Journal of Symbolic Logic, 2011
AbstractWe present a method to iterate finitely splitting lim-sup tree forcings along non-wellfounded linear orders. As an application, we introduce a new method to force (weak) measurability of all definable sets with respect to a certain (non-ccc) ideal.
Kellner, Jakob, Shelah, Saharon
openaire   +5 more sources

Effects of Saccharin Consumption on Operant Responding for Sugar Reward and Incubation of Sugar Craving in Rats

Foods, 2020
Repeated experience with artificial sweeteners increases food consumption and body weight gain in rats. Saccharin consumption may reduce the conditioned satiety response to sweet-tasting food. Rats were trained to press a lever to obtain sucrose for five
Kenjiro Aoyama, Akane Nagano
doaj   +1 more source

Behavioral Responses of Chicks to a Saccharin-Quinine Mixture

The Journal of Poultry Science, 2018
To date, few reports have been published on the sensitivity of birds to sweet tastes. Therefore, in this study, the behavioral responses of White Leghorn chicks to the sweet taste of saccharin and the bitter taste of quinine were assessed.
Tatsuyuki Yoshida, Yuichi Ito, Hiroki Furuta   +2 more
doaj   +1 more source

Corticosterone Regulates Both Naturally Occurring and Cocaine‐Induced Dopamine Signaling by Selectively Decreasing Dopamine Uptake [PDF]

, 2017
Stressful and aversive events promote maladaptive reward‐seeking behaviors such as drug addiction by acting, in part, on the mesolimbic dopamine system. Using animal models, data from our laboratory and others show that stress and cocaine can interact to
Baker, David A., Bohn, Austin T., Ebben, Amanda L., Gasser, Paul J., Jasek, Isabella A., Kurtoglu, Beliz, Lovell, Marissa E., Mantsch, John R., Wheeler, Daniel S., Wheeler, Robert A.   +9 more
core   +2 more sources

Reducing sulfur to improve thermal embrittlement in electrodeposited nickel using citric acid

Results in Surfaces and Interfaces, 2020
Electrodeposited nickel usage has been limited owing to thermal embrittlement at high temperatures. Electrodeposited nickel generally contains sulfur, and the grain boundary segregation of sulfur leads to thermal embrittlement.
Atsuya Watanabe, Yorinobu Takigawa
doaj   +1 more source

Multiple interaction modes between saccharin and sweet taste receptors determine a species‐dependent response to saccharin

FEBS Open Bio, 2022
Saccharin is a commonly used artificial sweetener that exhibits both sweetening and sweet inhibition activities. The species‐dependent response towards saccharin and the interaction between saccharin and the sweet taste receptor T1R2/T1R3 remain elusive.
Xiangzhong Zhao, Meng Liu, Meng Cui, Bo Liu   +3 more
doaj   +1 more source