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Sample Delivery Techniques for Serial Crystallography

, 2018
In serial femtosecond crystallography (SFX), protein microcrystals and nanocrystals are introduced into the focus of an X-ray free electron laser (FEL) beam ideally one-by-one in a serial fashion. The high photon density in each pulse is the double-edged sword that necessitates the serial nature of the experiments.
Sierra, Raymond G., Weierstall, Uwe, Oberthuer, Dominik, Sugahara, Michihiro, Nango, Eriko, Iwata, So, Meents, Alke   +6 more
semanticscholar   +4 more sources

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Microfluidic sample delivery for serial crystallography using XFELs

Analytical and Bioanalytical Chemistry, 2019
Serial femtosecond crystallography (SFX) with X-ray free electron lasers (XFELs) is an emerging field for structural biology. One of its major impacts lies in the ability to reveal the structure of complex proteins previously inaccessible with synchrotron-based crystallography techniques and allowing time-resolved studies from femtoseconds to seconds ...
Austin, Echelmeier, Mukul, Sonker, Alexandra, Ros   +2 more
openaire   +3 more sources

Sample Delivery System

2016
J. Broadwell
semanticscholar   +3 more sources

Stable sample delivery in a viscous medium via a polyimide-based single-channel microfluidic chip for serial crystallography

Journal of Applied Crystallography, 2021
Serial crystallography (SX) provides room-temperature crystal structures with minimal radiation damage and facilitates the comprehension of molecular dynamics through time-resolved studies.
K. Nam, Yunje Cho
semanticscholar   +1 more source

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Journal of Visualized Experiments, 2022
Although the blood-brain barrier (BBB) protects the brain from foreign entities, it also prevents some therapeutics from crossing into the central nervous system (CNS) to ameliorate diseases or infections. Drugs are administered directly into the CNS in animals and humans to circumvent the BBB.
Sara, Oberrauch, Jing, Lu, Linda, Cornthwaite-Duncan, Maytham, Hussein, Jian, Li, Gauri, Rao, Tony, Velkov   +6 more
openaire   +2 more sources

Turning on/off satellite droplet ejection for flexible sample delivery on digital microfluidics.

Lab on a Chip, 2020
Digital microfluidics has the potential to minimize and automate reactions in biochemical labs. However, the complexity of drop manipulation and sample preparation on-chip has limited its incorporation into daily workflow.
Haoran Li, Ren Shen, Cheng Dong, Tianlan Chen, Yanwei Jia, Pui-in Mak, R. Martins   +6 more
semanticscholar   +1 more source

URBER: Ultrafast Rule-Based Escape Routing Method for Large-Scale Sample Delivery Biochips

IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 2020
In high-throughput drug screening applications, as manual drug sample delivery is time-consuming and error-prone, there is an urgent need for accurate and efficient drug sample delivery biochip for large-scale microwell arrays.
Jiayi Weng, Tsung-Yi Ho, Weiqing Ji, Peng Liu, Mengdi Bao, Hailong Yao   +5 more
semanticscholar   +1 more source

A novel sample delivery system based on circular motion for in situ serial synchrotron crystallography.

Lab on a Chip, 2020
A sample delivery system is one of the key parts of serial crystallography. It is the main limiting factor affecting the application of serial crystallography.
F. Zhao, Bo Sun, Li Yu, Qing-Jie Xiao, Zhijun Wang, Liang‐Liang Chen, Huan Liang, Qi-Sheng Wang, Jian-Hua He, D. Yin   +9 more
semanticscholar   +1 more source

Vaginal birth after cesarean delivery in twin gestations: A large, nationwide sample of deliveries

American Journal of Obstetrics and Gynecology, 2006
The purpose of this study was to assess the maternal morbidity associated with attempted vaginal birth after cesarean (VBAC) in twin gestations using a large, nationwide sample of deliveries.Data for this study were obtained from an administrative dataset, the Nationwide Inpatient Sample, a representative sample of discharges from non-Federal hospitals,
Abigail A D, Ford, Brian T, Bateman, Lynn L, Simpson   +2 more
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Sample delivery using viscous media, a syringe and a syringe pump for serial crystallography.

Journal of Synchrotron Radiation, 2019
Sample delivery using injectors is widely used in serial crystallography (SX) and has significantly contributed to the determination of crystal structures at room temperature. However, sophisticated injector nozzle fabrication methods and sample delivery
Suk-Youl Park, K. Nam
semanticscholar   +1 more source