Results 1 to 10 of about 42,993 (322)
Distorting the sarcomere [PDF]
Journal of General Physiology, 2010 One of the goals of cardiovascular science is to create a mathematical model of the heart that can predict ventricular function in healthy and diseased states, and that can be used to help improve treatment options for patients with heart disease. To be clinically useful, the model will have to include structural information about the shapes of the ...
Kenneth S. Campbell
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Myomesin is part of an integrity pathway that responds to sarcomere damage and disease.
PLoS ONE, 2019 The structure and function of the sarcomere of striated muscle is well studied but the steps of sarcomere assembly and maintenance remain under-characterized.
Kendal Prill +4 more
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Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells. [PDF]
American Journal of Physiology-Cell Physiology, 2017 Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal ...
D. Rassier
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In vivo sarcomere lengths and sarcomere elongations are not uniform across an intact muscle
Frontiers in Physiology, 2016 Sarcomere lengths have been a crucial outcome measure for understanding and explaining basic muscle properties and muscle function. Sarcomere lengths for a given muscle are typically measured at a single spot, often in the mid-belly of the muscle, and at
Eng Kuan eMoo +4 more
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Sarcomere Dysfunction in Nemaline Myopathy
Journal of Neuromuscular Diseases, 2017 Nemaline myopathy (NM) is among the most common non-dystrophic congenital myopathies (incidence 1:50.000). Hallmark features of NM are skeletal muscle weakness and the presence of nemaline bodies in the muscle fiber. The clinical phenotype of NM patients
Josine M de Winter, C. Ottenheijm
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Differentiation and Contractile Analysis of GFP‐Sarcomere Reporter hiPSC‐Cardiomyocytes
Current Protocols in Human Genetics, 2018 Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) represent a powerful cellular platform for illuminating mechanisms of human cardiovascular disease and for pharmacological screening.
Arun Sharma +4 more
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Sarcomeric versus Non-Sarcomeric HCM
Cardiogenetics, 2023 Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions. HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins ...
Borrelli, Felice +8 more
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Structure of the native myosin filament in the relaxed cardiac sarcomere
Nature, 2023 The thick filament is a key component of sarcomeres, the basic units of striated muscle^ 1 . Alterations in thick filament proteins are associated with familial hypertrophic cardiomyopathy and other heart and muscle diseases^ 2 .
Davide Tamborrini +10 more
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Frontiers in Physiology, 2022 The lengths of a muscle’s sarcomeres are a primary determinant of its ability to contract and produce force. In addition, sarcomere length is a critical parameter that is required to make meaningful comparisons of both the force-generating and excursion ...
Amy N. Adkins +12 more
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bioRxiv, 2023 Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro +7 more
semanticscholar +1 more source