Results 61 to 70 of about 65,186 (354)
Biomedicines, 2022 The intermediate filament protein desmin is essential for maintaining the structural integrity of sarcomeres, the fundamental unit of cardiac muscle. Diabetes mellitus (DM) can cause desmin to become dysregulated, following episodes of nitrosative stress,
Amal F. Dawood +10 more
doaj +1 more source
Effects of Low Cell pH and Elevated Inorganic Phosphate on the pCa-Force Relationship in Single Muscle Fibers at Near-Physiological Temperatures [PDF]
, 2014 Intense muscle contraction induces high rates of ATP hydrolysis with resulting increases in Pi, H+, and ADP, factors thought to induce fatigue by interfering with steps in the cross-bridge cycle.
Fitts, Robert H., Nelson, Cassandra R.
core +2 more sources
Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]
, 2020 Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo +5 more
core +1 more source
Sarcomere Mechanics in the Stress Fiber [PDF]
Biophysical Journal, 2009 Actin filaments inside endothelial cells assemble into tensed bundles called stress fibers. Stress fibers are observed in vivo in a variety of tissues including the aorta, the heart, the spleen, the eye, and hair follicles. Sarcomeres are the force generating units of stress fibers and are responsible for generating intracellular tension.
Tanmay P. Lele +2 more
openaire +2 more sources
Molecules, 2013 Sun-dried beef is a frequently consumed and valued product in Brazil, however, there have been no scientific studies on its texture. To assess the tenderness of sun-dried beef, an instrumental analysis (Warner-Bratzler Shear Force; WBSF), a sensory ...
Marta Madruga +4 more
doaj +1 more source
Cells, 2020 The maintenance of skeletal muscle mass plays a critical role in health and quality of life. One of the most potent regulators of skeletal muscle mass is mechanical loading, and numerous studies have led to a reasonably clear understanding of the ...
Kent W. Jorgenson +2 more
doaj +1 more source
Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]
, 2019 With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal +30 more
core +1 more source
Sarcomeric dysfunction in heart failure [PDF]
Cardiovascular Research, 2007 Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and
Hamdani, N. +8 more
openaire +4 more sources
A next-generation sequencing approach to identify gene mutations in early-and late-onset hypertrophic cardiomyopathy patients of an Italian cohort [PDF]
, 2016 Sequencing of sarcomere protein genes in patients fulfilling the clinical diagnostic criteria for hypertrophic cardiomyopathy (HCM) identifies a disease-causing mutation in 35% to 60% of cases.
Autore, Camillo +11 more
core +1 more source
Sarcomere and Inter-Sarcomere Dynamics within Skeletal Muscle Myofibrils [PDF]
Biophysical Journal, 2017 Introduction: Inter-sarcomere dynamics within muscle myofibrils underlie basic mechanisms of contraction. In this study, we used microfluidic perfusions to control the environment of sarcomeres within isolated myofibrils to directly investigate inter-sarcomere dynamics.
Dilson E. Rassier, Felipe de Souza Leite
openaire +2 more sources