Results 1 to 10 of about 16,570 (272)

Sarcomeric versus Non-Sarcomeric HCM

Cardiogenetics, 2023
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and is characterized by left ventricular hypertrophy (LVH), which is unexplained by abnormal loading conditions.
Felice Borrelli, Maria Angela Losi, Grazia Canciello, Gaetano Todde, Errico Federico Perillo, Leopoldo Ordine, Giulia Frisso, Giovanni Esposito, Raffaella Lombardi   +8 more
doaj   +3 more sources

Does eccentric strength training add sarcomeres in series and subtract sarcomeres in parallel? [PDF]

Journal of Sport and Health Science
Bart Bolsterlee, Paolo Tecchio, Daniel Hahn, Brent J. Raiteri   +3 more
doaj   +2 more sources

α- and β-myosin II can be non-uniformly distributed within the cardiac sarcomere. [PDF]

iScience
Hayes JB, Willet AH, Caplan LR, Knapik EW, Tyska MJ, Burnette DT.   +5 more
europepmc   +2 more sources

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

eLife, 2023
Sarcomeres are the basic contractile units within cardiac myocytes, and the collective shortening of sarcomeres aligned along myofibrils generates the force driving the heartbeat.
Abigail C Neininger-Castro, James B Hayes, Zachary C Sanchez, Nilay Taneja, Aidan M Fenix, Satish Moparthi, Stéphane Vassilopoulos, Dylan Tyler Burnette   +7 more
doaj   +1 more source

Genotype-Phenotype Associations with Restrictive Cardiomyopathy Induced by Pathogenic Genetic Mutations

Reviews in Cardiovascular Medicine, 2022
Restrictive cardiomyopathy (RCM) is an uncommon cardiac muscle disease characterized by impaired ventricular filling and severe diastolic dysfunction with or without systolic dysfunction.
Zhe Yang, Jia Chen, Hong Li, Yubi Lin
doaj   +1 more source

Ion Channel Impairment and Myofilament Ca²⁺ Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy

Cells, 2021
Life-threatening ventricular arrhythmias are the main clinical burden in patients with hypertrophic cardiomyopathy (HCM), and frequently occur in young patients with mild structural disease.
Lorenzo Santini, Raffaele Coppini, Elisabetta Cerbai   +2 more
doaj   +1 more source

New indexes for myofibril linearity in muscle image analysis

European Journal of Translational Myology, 2022
The endeavor to evaluate the linearity of myofibrillar structures and their potential deviation from a straight line is a fascinating problem in muscle tissue image analysis.
Ettore Rocchi, Sara Peluso, Stefano Amatori, Davide Sisti   +3 more
doaj   +1 more source

Cooperation between myofibril growth and costamere maturation in human cardiomyocytes

Frontiers in Bioengineering and Biotechnology, 2022
Costameres, as striated muscle-specific cell adhesions, anchor both M-lines and Z-lines of the sarcomeres to the extracellular matrix. Previous studies have demonstrated that costameres intimately participate in the initial assembly of myofibrils ...
Huaiyu Shi, Huaiyu Shi, Chenyan Wang, Chenyan Wang, Bruce Z. Gao, James H. Henderson, James H. Henderson, Zhen Ma, Zhen Ma   +8 more
doaj   +1 more source

Microtubules orchestrate local translation to enable cardiac growth

Nature Communications, 2021
New contractile units are required during cardiac hypertrophy, though it remains unclear precisely where and how these new sarcomeres are added. Here the authors reveal that in the heart, microtubules spatiotemporally regulate mRNAs and ribosomes to ...
Emily A. Scarborough, Keita Uchida, Maria Vogel, Noa Erlitzki, Meghana Iyer, Sai Aung Phyo, Alexey Bogush, Izhak Kehat, Benjamin L. Prosser   +8 more
doaj   +1 more source

Sarc-Graph: Automated segmentation, tracking, and analysis of sarcomeres in hiPSC-derived cardiomyocytes.

PLoS Computational Biology, 2021
A better fundamental understanding of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) has the potential to advance applications ranging from drug discovery to cardiac repair.
Bill Zhao, Kehan Zhang, Christopher S Chen, Emma Lejeune   +3 more
doaj   +1 more source