Results 31 to 40 of about 16,570 (272)
eLife, 2018 Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics resource of developing Drosophila flight muscles and identified 40 ...
Maria L Spletter +10 more
doaj +1 more source
Sarcomere lengths in wooden breast broiler chickens
Italian Journal of Animal Science, 2020 The present study aims to measure the sarcomere lengths in normal broiler muscles and in non-lesion sites of breast muscles focally affected by Wooden Breast (WB).
Francesca Soglia +2 more
doaj +1 more source
Molecular-scale visualization of sarcomere contraction within native cardiomyocytes
Nature Communications, 2021 Sarcomeres, the building blocks of striated muscles, comprise ordered actomyosin arrays involved in force production. Here, the authors visualize sarcomere organization in neonatal cardiomyocytes with in situ cryo-electron tomography, revealing a reduced
Laura Burbaum +7 more
doaj +1 more source
Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells [PDF]
American Journal of Physiology-Cell Physiology, 2017 Muscle contraction is commonly associated with the cross-bridge and sliding filament theories, which have received strong support from experiments conducted over the years in different laboratories. However, there are studies that cannot be readily explained by the theories, showing 1) a plateau of the force-length relation extended beyond optimal ...
openaire +2 more sources
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination
eLife, 2017 Maintenance of muscle function requires assembly of contractile proteins into highly organized sarcomeres. Mutations in Kelch-like protein 41 (KLHL41) cause nemaline myopathy, a fatal muscle disorder associated with sarcomere disarray.
Andres Ramirez-Martinez +6 more
doaj +1 more source
The sarcomeric cytoskeleton: from molecules to motion [PDF]
Journal of Experimental Biology, 2016 ABSTRACT Highly ordered organisation of striated muscle is the prerequisite for the fast and unidirectional development of force and motion during heart and skeletal muscle contraction. A group of proteins, summarised as the sarcomeric cytoskeleton, is essential for the ordered assembly of actin and myosin filaments into sarcomeres, by ...
Gautel, Mathias +1 more
openaire +4 more sources
Nature Communications, 2022 How different physical configurations between sarcomeres and mitochondria alter energetic support for contractile function of skeletal muscle is not clear.
Prasanna Katti +8 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki +8 more
wiley +1 more source
Journal of Sport and Health Science, 2022 Background: Eccentric exercise increases muscle fascicle lengths; however, the mechanisms behind this adaptation are still unknown. This study aimed to determine whether biceps femoris long head (BFlh) fascicle length increases in response to 3 weeks of ...
Patricio A. Pincheira +4 more
doaj +1 more source