Results 51 to 60 of about 11,481 (144)

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, Volume 12, Issue 21, June 5, 2025.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Effects of resistive exercise and stretching on the soleus muscle of ovariectomized rats

Fisioterapia e Pesquisa, 2016
This study analyzed the effects of resistive exercise and/or stretching in the muscle morphology of ovariectomized rats. Seventy-five female Wistar rats (218±22g) were divided into 8 groups: Control (CONTROL, n=5); Ovariectomy/Hysterectomy (OH, n=10 ...
Julye Leiko Ywazaki, Ana Paula Cunha Loureiro, Talita Gianello Gnoato Zotz, Luana Ribeiro Nascimento, Douglas Vizzu Nobre, Anna Raquel Silveira Gomes   +5 more
doaj   +1 more source

Knockout of rbm24a and rbm24b genes in zebrafish impairs skeletal and cardiac muscle integrity and function during development

Developmental Dynamics, Volume 254, Issue 5, Page 420-435, May 2025.
Abstract Backgound Skeletal and cardiac muscles are contractile tissues whose development and function are dependent on genetic programs that must be precisely orchestrated in time and space. In addition to transcription factors, RNA‐binding proteins tightly regulate gene expression by controlling the fate of RNA transcripts, thus specific proteins ...
Audrey Saquet, Ziwei Ying, De‐Li Shi, Raphaëlle Grifone   +3 more
wiley   +1 more source

Image3_Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise.pdf

, 2022
In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs ...
Emma Hjalmarsson (8631381), Ivan J. Vechetti (14287415), Björn Alkner (14053251), Ferdinand von Walden (8631396), Alexandra Palmcrantz (8631387), Jessica Pingel (743013), Jessica Norrbom (14287418), Eva Pontén (8631393), Rodrigo Fernandez-Gonzalo (3094740)   +8 more
core   +1 more source

Flywheel resistance training promotes unique muscle architectural and performance‐related adaptations in young adults

European Journal of Sport Science, Volume 24, Issue 12, Page 1765-1778, December 2024.
Abstract The purpose of this study was to examine the skeletal muscle hypertrophic, architectural, and performance‐related adaptations in response to volume‐matched, total‐body flywheel versus traditional resistance training in a randomized, non‐exercise controlled study in physically active young adults. Thirty‐one healthy young adults (24 ± 3 y) were
Nile F. Banks, Alexander C. Berry, Emily M. Rogers, Nathaniel D. M. Jenkins   +3 more
wiley   +1 more source

Muscle type‐specific effects of bilateral abobotulinumtoxinA injection on muscle growth and contractile function in spastic mice

The FASEB Journal, Volume 38, Issue 22, 30 November 2024.
Wild‐type and spastic mice were injected into the calf muscle with saline or abobotulinumtoxinA to investigate its effects on muscle function and morphology. Nine weeks post‐injection, abobotulinumtoxinA altered muscle morphology and function in both types of mice, reducing physiological cross‐sectional area due to fewer muscle fibers.
Cintia Rivares, Alban Vignaud, Wendy Noort, Guus Baan, Bastijn Koopmans, Maarten Loos, Rob C. I. Wüst, Mikhail Kalinichev, Richard T. Jaspers   +8 more
wiley   +1 more source

Cofilin loss in Drosophila contributes to myopathy through defective sarcomerogenesis and aggregate formation during muscle growth [PDF]

, 2019
SUMMARY Sarcomeres, the fundamental contractile units of muscles, are conserved structures composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed and maintained is not well understood. Here, we show that knockdown of Drosophila Cofilin (
Balakrishnan, Mridula, Yu, Shannon F., Chin, Samantha M., Soffar, David B., Windner, Stefanie E., Goode, Bruce L., Baylies, Mary K.   +6 more
openaire   +1 more source

Pain-induced changes in the activity of the cervical extensor muscles evaluated by muscle functional magnetic resonance imaging

, 2011
The repeated bout effect characterizes the protective adaptation after a single bout of unaccustomed eccentric exercise that induces muscle damage. Sarcomerogenesis and increased tendon compliance have been suggested as potential mechanisms for the ...
Peeters, Ian, Ian Peeters, Cagnie, Barbara, O'leary, Shaun, Parlevliet, Thierry, James Elliott, Danneels, Lieven, Elliott, James, Lieven Danneels, Shaun O'leary, Thierry Parlevliet, Barbara Cagnie   +11 more
core   +1 more source

Image2_Extracellular vesicle characteristics and microRNA content in cerebral palsy and typically developed individuals at rest and in response to aerobic exercise.pdf

, 2022
In this study, the properties of circulating extracellular vesicles (EVs) were examined in cerebral palsy (CP) and typically developed (TD) individuals at rest and after aerobic exercise, focusing on the size, concentration, and microRNA cargo of EVs ...
Emma Hjalmarsson (8631381), Ivan J. Vechetti (14287415), Björn Alkner (14053251), Ferdinand von Walden (8631396), Alexandra Palmcrantz (8631387), Jessica Pingel (743013), Jessica Norrbom (14287418), Eva Pontén (8631393), Rodrigo Fernandez-Gonzalo (3094740)   +8 more
core   +1 more source

Cardiomyopathy: pathogenesis and therapeutic interventions

MedComm, Volume 5, Issue 11, November 2024.
Cardiomyopathy is a group of diseases characterized by structural and functional damage to the myocardium. Many specific gene mutations, environmental factors, and metabolic disorders may cause cardiomyopathy. Traditional therapeutic includes drug and surgery. With the growing comprehension of the molecular mechanisms underlying cardiomyopathy.
Shitong Huang, Jiaxin Li, Qiuying Li, Qiuyu Wang, Xianwu Zhou, Jimei Chen, Xuanhui Chen, Abdelouahab Bellou, Jian Zhuang, Liming Lei   +9 more
wiley   +1 more source