Results 161 to 170 of about 79,406 (256)

Sarcoplasmic reticulum-mitochondria microdomains: hugging and kissing in the heart. [PDF]

Am J Physiol Cell Physiol
Jhun BS, O-Uchi J, Rhee B, Ahrari A, DeMichaelis N, Jeon KI, Booth DM, Sheu SS.   +7 more
europepmc   +1 more source

Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA. [PDF]

Biochemistry, 2022
Bak JJ, Aguayo-Ortiz R, Rathod N, Primeau JO, Khan MB, Robia SL, Lemieux MJ, Espinoza-Fonseca LM, Young HS.   +8 more
europepmc   +1 more source

Small‐conductance Ca2⁺‐activated K⁺ channels in cardiac excitation–contraction coupling: Bridging mitochondria, sarcolemma and antiarrhythmic therapy

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev, Alexey V. Glukhov, Vladimir Bogdanov, Aleksei S. Averin, Roland Veress, Bum‐Rak Choi, Shanna Hamilton, Andriy E. Belevych   +7 more
wiley   +1 more source

TRIC-A Facilitates Sarcoplasmic Reticulum-Mitochondrial Ca²⁺ Signaling Crosstalk in Cardiomyocytes. [PDF]

Cells
Li A, Zhou X, Park KH, Yi J, Li X, Ko JK, Chen Y, Nishi M, Yamazaki D, Takeshima H, Zhou J, Ma J.   +11 more
europepmc   +1 more source

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse. [PDF]

Front Physiol, 2021
Edwards AG, Mørk H, Stokke MK, Lipsett DB, Sjaastad I, Richard S, Sejersted OM, Louch WE.   +7 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Protocol for Enrichment of Murine Cardiac Junctional Sarcoplasmic Reticulum Vesicles for Mass Spectrometry Analysis. [PDF]

Int J Mol Sci
Di Antonio C, Marabelli C, Bongianino R, Priori SG.   +3 more
europepmc   +1 more source

Alterations of sarcoplasmic reticulum-mediated Ca²⁺ uptake in a model of premature ventricular contraction (PVC)-induced cardiomyopathy. [PDF]

Mol Cell Biochem, 2023
Balderas-Villalobos J, Medina-Contreras JML, Lynch C, Kabadi R, Ramirez RJ, Tan AY, Kaszala K, Samsó M, Huizar JF, Eltit JM.   +9 more
europepmc   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Functionally Isolated Sarcoplasmic Reticulum in Cardiomyocytes: Experimental and Mathematical Models. [PDF]

Bioengineering (Basel)
Soriano DC, Bassani RA, Bassani JWM.
europepmc   +1 more source