Results 181 to 190 of about 79,406 (256)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Modeling sarcoplasmic reticulum Ca²⁺ in rat cardiomyocytes. [PDF]

Biophys Rep
Su Y, Liang Y, Xu M, Gao B, Zhang S, Yang E, Yin S, Li D, Huang Z, Xie W.   +9 more
europepmc   +1 more source

Mitigating sarcoplasmic reticulum stress limits disuse-induced muscle loss in hindlimb unloaded mice. [PDF]

NPJ Microgravity, 2022
Khan AA, Gul MT, Karim A, Ranade A, Azeem M, Ibrahim Z, Ramachandran G, Nair VA, Ahmad F, Elmoselhi A, Qaisar R.   +10 more
europepmc   +1 more source

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

EMC1 Is Required for the Sarcoplasmic Reticulum and Mitochondrial Functions in the Drosophila Muscle. [PDF]

Biomolecules
Couto-Lima CA, Machado MCR, Anhezini L, Oliveira MT, Molina RADS, da Silva RR, Lopes GS, Trinca V, Colón DF, Peixoto PM, Monesi N, Alberici LC, Ramos RGP, Espreafico EM.   +13 more
europepmc   +1 more source

Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk. [PDF]

JACC Clin Electrophysiol, 2021
Jiang N, Zhou A, Imran H, Shi G, Kaseer B, Siu V, Chu AF, Donaldson DM, Kirk MM, Philips BB, Dudley SC.   +10 more
europepmc   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Assaying sarcoplasmic reticulum Ca²⁺-leak in mouse atrial myocytes. [PDF]

Biophys Rep
Xu F, Li JJ, Yang E, Zhang Y, Xie W.
europepmc   +1 more source

Distributed synthesis of sarcolemmal and sarcoplasmic reticulum membrane proteins in cardiac myocytes. [PDF]

Basic Res Cardiol, 2021
Bogdanov V, Soltisz AM, Moise N, Sakuta G, Orengo BH, Janssen PML, Weinberg SH, Davis JP, Veeraraghavan R, Györke S.   +9 more
europepmc   +1 more source