Results 271 to 280 of about 51,493 (310)

The cellular biology of scavenger receptor class B type I

Current Opinion in Lipidology, 2001
The HDL receptor scavenger receptor class B type I plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear.
D L, Silver, A R, Tall
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HDL and Scavenger Receptor Class B Type I (SRBI)

2022
The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis.
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Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target

Immunotherapy, 2011
Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed
Jessica, Fioravanti, José, Medina-Echeverz, Pedro, Berraondo   +2 more
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Hyperglycemia suppresses hepatic scavenger receptor class B type I expression

American Journal of Physiology-Endocrinology and Metabolism, 2008
Hyperglycemia is a major risk factor for atherosclerotic disease. Hepatic scavenger receptor class B type I (SR-BI) binds HDL particles that mediate reverse cholesterol transport and thus lowers the risk of atherosclerosis. Here we examined glucose regulation of SR-BI gene expression in both HepG2 cells and whole animals. Results showed that hepatic SR-
Koji, Murao, Xiao, Yu, Hitomi, Imachi, Wen M, Cao, Ke, Chen, Kensuke, Matsumoto, Takamasa, Nishiuchi, Norman C W, Wong, Toshihiko, Ishida   +8 more
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Functions of scavenger receptor class B, type I in atherosclerosis

Current Opinion in Lipidology, 2012
This review highlights the diverse roles of the high-affinity HDL receptor scavenger receptor class B, type I (SR-BI) in the modulation of global cholesterol homeostasis and vascular cell function, and the potential implications of these processes in atherosclerosis.SR-BI in the liver plays a critical role in reverse cholesterol transport and it ...
Chieko, Mineo, Philip W, Shaul
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Interaction of scavenger receptor class B type I with peroxisomal targeting receptor Pex5p

Biochemical and Biophysical Research Communications, 2003
Scavenger receptor class B type I (SR-BI) is an HDL receptor that mediates selective HDL lipid uptake. Peroxisomes play an important role in lipid metabolism and peroxisomal targeting signal type 1 (PTS1)-containing proteins are translocated to peroxisomes by the peroxisomal targeting import receptor, Pex5p.
Magnus S C, Johnson, Jenny M, Johansson, Per Arne, Svensson, Maria A I, Aberg, Peter S, Eriksson, Lena M S, Carlsson, Björn, Carlsson   +6 more
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Scavenger receptor class B type 1 gene polymorphisms and female fertility

Current Opinion in Endocrinology, Diabetes & Obesity, 2012
Multiple studies have demonstrated a role for scavenger receptor class B type 1 (SR-B1) in female fertility. Recent studies have implicated specific SR-B1 gene polymorphisms in decreased progesterone production and suboptimal fertility outcomes.The lipoprotein receptor SR-B1 has been known to mediate selective uptake of lipids into steroidogenic ...
Mindy S, Christianson, Melissa, Yates
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Role of CD36, the Macrophage Class B Scavenger Receptor, in Atherosclerosis

Annals of the New York Academy of Sciences, 2001
Abstract: Recent work in the field of atherosclerosis has greatly expanded our knowledge of the pathogenesis of this disease. Scavenger receptors, including CD36, are thought to be most important early in the disease progression during macrophage uptake of modified LDL and foam cell formation.
A C, Nicholson, J, Han, M, Febbraio, R L, Silversterin, D P, Hajjar   +4 more
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Scavenger receptor class B type I polymorphisms and peripheral arterial disease

Metabolism, 2007
Genetic variations of the scavenger receptor class B type I (SR-BI) have been demonstrated to be associated with plasma lipid parameters, anthropomorphic parameters, and coronary artery disease. We determined the frequency of 3 single-nucleotide polymorphisms within the SR-BI gene (SCARB1) in 354 patients with peripheral arterial disease (PAD) and 354 ...
Andreas, Ritsch, Gudrun, Sonderegger, Gudron, Sonderegger, Anton, Sandhofer, Ursula, Stanzl, Ursala, Stanzl, Ivan, Tancevski, Philipp, Eller, Wilfried, Schgoer, Andreas, Wehinger, Thomas, Mueller, Meinhard, Haltmayer, Josef R, Patsch, Joseph R, Patsch   +13 more
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Characterization of scavenger receptor class B

2009
Besides its housekeeping functions in all mammalian cells, cholesterol contributes to different biological functions like bile acid-, vitamin D- or steroid hormone synthesis. Thus, multiple pathways have evolved to ensure full supply of animal cells with cholesterol, involving different lipoproteins and cell surface receptors.
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