Results 91 to 100 of about 35,905 (251)

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

In vivo imaging of prostate cancer using an anti-PSMA scFv fragment as a probe

Scientific Reports, 2016
We aimed to evaluate a fluorescent-labeled single chain variable fragment (scFv) of the anti-PSMA antibody as a specific probe for the detection of prostate cancer by in vivo fluorescence imaging.
C. Mazzocco, G. Fracasso, Coralie Germain-Genevois, Nathalie Dugot-Senant, M. Figini, M. Colombatti, N. Grenier, F. Couillaud   +7 more
semanticscholar   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

RGD-p21Ras-scFv expressed prokaryotically on a pilot scale inhibits ras-driven colorectal cancer growth by blocking p21Ras-GTP

BMC Cancer
Background Ras gene mutation and/or overexpression are drivers in the progression of cancers, including colorectal cancer. Blocking the Ras signaling has become a significant strategy for cancer therapy. Previously, we constructed a recombinant scFv, RGD-
Peng Lin, Jing Qian, Cheng-Cheng Huang, Wen-Mang Xu, Yuan-Yuan Wang, Zi-Ran Gao, Shi-Qi Zheng, Peng Wang, Da-Qi Jia, Qiang Feng, Ju-Lun Yang   +10 more
doaj   +1 more source

Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors

Oncoimmunology, 2016
Engineering potent bispecific antibodies from single-chain variable fragments (scFv) remains difficult due to the inherent instability and insufficient binding of scFv's compared to their parental immunoglobulin format.
M. Cheng, B. Santich, Hong Xu, Mahiuddin Ahmed, M. Huse, N. Cheung   +5 more
semanticscholar   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, EarlyView.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Preventive Activity against Influenza (H1N1) Virus by Intranasally Delivered RNA-Hydrolyzing Antibody in Respiratory Epithelial Cells of Mice

Viruses, 2015
The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for intranasal administration against avian influenza virus (H1N1) was described.
Seungchan Cho, Ha-Na Youn, Phuong Mai Hoang, Sungrae Cho, Kee-Eun Kim, Eui-Joon Kil, Gunsup Lee, Mun-Ju Cho, Juhyun Hong, Sung-June Byun, Chang-Seon Song, Sukchan Lee   +11 more
doaj   +1 more source

Diagnostic antibodies at an inflection point: From discovery platforms to design‐oriented engineering

VIEW, EarlyView.
This study systematically organizes the evolution of diagnostic antibodies from discovery platforms to design‐oriented engineering and analyzes the strengths and limitations of each approach. Meanwhile, it provides a critical, literature‐driven synthesis of current challenges, proposing integrated strategies for assay‐aware and function‐driven antibody
Qitao Song, Lulai Xu, Weilin Wu, Fei Xie, Yantong Pan, Tiantian Yang, Xiaoxia Xu, Yanyin Lin, Lihua Zhang, Jiahui Zhou, Junyou Zhou, Linping Li, Zhanhui Wang, Weijing Yi, Jing Wang   +14 more
wiley   +1 more source

Production and functional activity of scFv fragments obtained from recombinant antibodies against influenza virus

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Passive immunotherapy using broad-spectrum antibodies is a promising development vector of new drugs against influenza. However, production process, purification, and storage of clinically suitable recombinant antibodies still face ...
M. A. Plotnikova, V. A. Toporova, E. A. Romanovskaya-Romanko, A. A. Shaldzhyan, S. A. Klotchenko   +4 more
doaj   +1 more source

Generation of recombinant scFv antibody against Ochratoxin A (OTA)

Indonesian Journal of Biotechnology, 2018
Ochratoxin A (OTA) is a mycotoxin commonly found in agricultural products and can accumulate in the blood and tissues after that consuming contaminated food.
Ranya Pranomphon, Witsanu Srila, Montarop Yamabhai   +2 more
doaj   +1 more source