Results 111 to 120 of about 44,698 (301)

Cell-type specific potent Wnt signaling blockade by bispecific antibody. [PDF]

, 2018
Cell signaling pathways are often shared between normal and diseased cells. How to achieve cell type-specific, potent inhibition of signaling pathways is a major challenge with implications for therapeutic development.
Bidlingmaier, Scott, Ha, Kevin D, Lee, Nam-Kyung, Liu, Bin, Sherbenou, Daniel W, Su, Yang, Zhang, Yafeng   +6 more
core   +2 more sources

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo [PDF]

, 2007
BACKGROUND: We have treated three patients with carboxy-anhydrase-IX (CAIX) positive metastatic renal cell cancer (RCC) by adoptive transfer of autologous T-cells that had been gene-transduced to express a single-chain antibody-G250 chimeric receptor ...
C Lamers, C Yee, CH Lamers, CH Lamers, CH Lamers, CH Lamers, CHJ Lamers, Cor H. J. Lamers, Corrien M. Groot-van Ruijven, E Oosterwijk, FG Rolfe, H Uemura, HF Pross, Jan Willem Gratama, K Grabmaier, K Vandenbroeck, L Gattinoni, ME Dudley, ME Weijtens, RA Willemsen, Reno Debets, RL Bolhuis, Sabine C. L. Langeveld, SP Umland, Stefan Sleijfer, TM Clay, WC Cragun, Z Eshhar   +27 more
core   +5 more sources

Generation of Allogeneic CAR‐T Circumvents Functional Deficits in Patient‐Derived Autologous Product for Glioblastoma

International Journal of Cancer, EarlyView.
Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim, Muhammad Vaseem Shaikh, Jeffrey Wei, William T. Maich, Alisha Anand, Oliver Y. Tang, Minomi K. Subapanditha, Zahra Alizada, Yujin Suk, Manoj Singh, Kui Zhai, Aapti Khanna, Benjamin Brakel, Vassil Dimitrov, Zoya Tabunshchyk, Katie Chan, Kevin R. Brown, Parvez Vora, Donald M. O'Rourke, Zev A. Binder, Chitra Venugopal, Jason Moffat, Sheila K. Singh   +22 more
wiley   +1 more source

Preventive Activity against Influenza (H1N1) Virus by Intranasally Delivered RNA-Hydrolyzing Antibody in Respiratory Epithelial Cells of Mice

Viruses, 2015
The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for intranasal administration against avian influenza virus (H1N1) was described.
Seungchan Cho, Ha-Na Youn, Phuong Mai Hoang, Sungrae Cho, Kee-Eun Kim, Eui-Joon Kil, Gunsup Lee, Mun-Ju Cho, Juhyun Hong, Sung-June Byun, Chang-Seon Song, Sukchan Lee   +11 more
doaj   +1 more source

Alphafold2 models of 47G4 (Hu19) scFv dimers and of VLVL dimers

, 2023
Philippe Youkharibache
openalex   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Production and functional activity of scFv fragments obtained from recombinant antibodies against influenza virus

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Passive immunotherapy using broad-spectrum antibodies is a promising development vector of new drugs against influenza. However, production process, purification, and storage of clinically suitable recombinant antibodies still face ...
M. A. Plotnikova, V. A. Toporova, E. A. Romanovskaya-Romanko, A. A. Shaldzhyan, S. A. Klotchenko   +4 more
doaj   +1 more source

Generation of recombinant scFv antibody against Ochratoxin A (OTA)

Indonesian Journal of Biotechnology, 2018
Ochratoxin A (OTA) is a mycotoxin commonly found in agricultural products and can accumulate in the blood and tissues after that consuming contaminated food.
Ranya Pranomphon, Witsanu Srila, Montarop Yamabhai   +2 more
doaj   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source