Results 71 to 80 of about 23,836 (161)

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

The FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro, Aurore Dougé, Klara Krpina, Lea‐Marie Schmitz, Christopher Forcados, Fatemeh Kaveh, Andrea Estrella Arias‐Díaz, Pascal Gelebart, Emmet McCormack, Renata Stripecke, Miguel Abal, Ben Davidson, Else Marit Inderberg, Sébastien Wälchli   +13 more
wiley   +1 more source

Production and functional activity of scFv fragments obtained from recombinant antibodies against influenza virus

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. Passive immunotherapy using broad-spectrum antibodies is a promising development vector of new drugs against influenza. However, production process, purification, and storage of clinically suitable recombinant antibodies still face ...
M. A. Plotnikova, V. A. Toporova, E. A. Romanovskaya-Romanko, A. A. Shaldzhyan, S. A. Klotchenko   +4 more
doaj   +1 more source

Targeted therapies in pemphigus vulgaris: Emerging horizons beyond rituximab

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Rituximab‐refractory pemphigus vulgaris is driven by B‐cell repopulation, plasma‐cell persistence, IgG4 autoantibodies and anti‐drug antibodies. This review evaluates five emerging targeted classes acting at successive steps of disease: next‐generation anti‐CD20 antibodies, DSG3‐CAAR T cells, BTK inhibitors, BAFF/APRIL inhibitors and FcRn antagonists ...
Rhea Ahuja, Dedee Murrell
wiley   +1 more source

Generation of recombinant scFv antibody against Ochratoxin A (OTA)

Indonesian Journal of Biotechnology, 2018
Ochratoxin A (OTA) is a mycotoxin commonly found in agricultural products and can accumulate in the blood and tissues after that consuming contaminated food.
Ranya Pranomphon, Witsanu Srila, Montarop Yamabhai   +2 more
doaj   +1 more source

Clinical Laboratory Innovations: Nanoscale Detection of Chloramphenicol Using Nanomaterial Biosensors

Analytical Science Advances, Volume 7, Issue 2, December 2026.
Nanosensor schematic functionalized with specific bioreceptors that produce electrochemical signals upon Chloramphenicol binding. Resulting voltammetric readouts (differential pulse, square‐wave, and cyclic voltammetry) are analyzed to identify and quantify Chloramphenicol.
Nava Moghadasian Niaki, Reza Kheradmand, Seyedeh Giso Akbarian, Elham Shaterian, Hamed Shaterian, Ahmad Mobed   +5 more
wiley   +1 more source

Synergistic Regulation of Biomaterials and Macrophages: A Novel Paradigm in Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 4, December 2026.
Bioengineered materials mediating the modulation of macrophage plasticity and inflammatory signals in the tumor microenvironment effectively remodel immunoregulatory states, boost antitumor immunity, and promote tissue repair, achieving synergistic therapeutic outcomes.
Jiayu Zhang, Songhang Xing, Shanshan Zhang, Yuan Hao, Xiaojie Qu, Wurihan Bao, Manwei Hao, Han Sun, Mingyuan Dong, Huiling Zhang, Dan Huang, Yiqi Wang, Xuanjie Jiang, Xiaoyu Pu, Yanyan Chi, Xingtong Wang, Xuefeng Li   +16 more
wiley   +1 more source

Bispecific NK‐Cell Engager Targeting TP53 Mutation Through Integration of a TCR‐mimic Antibody

MedComm, Volume 7, Issue 11, November 2026.
Most existing NK cell engagers (NKCEs) target tumor‐associated antigens (TAAs), risking on‐target, off‐tumor toxicity. We engineered a novel NKCE termed C33×CD16, a single‐chain diabody (scDb) constructed by fusing TCR‐mimic antibody C33‐Ab (targeting p53R175H/HLA‐A*02:01) to the scFv of 3G8 (anti‐CD16 antibody) (a).
Hanfei Wu, Zhe Zhao, Li Zhang, Xuan Xiong, Mengdie Yang, Weiping Ge, Danyue Zhi, Xiaobin Cao, Chuanqian Yi, Yong Qiao, Junjun Cao, Yan Mei, Shiping Jiao, Quan Liu, Hao Zhou, Zhongjuan Xu, Guangli Suo   +16 more
wiley   +1 more source

Pharmacokinetic parameters and mechanism of action of an efficient anti-Aβ single chain antibody fragment.

PLoS ONE, 2019
The success of the targeting of amyloid-β (Aβ) oligomers through immunotherapy in Alzheimer's disease (AD) mouse models has not been translated into the clinics.
Gisela Esquerda-Canals, Joaquim Martí-Clúa, Sandra Villegas   +2 more
doaj   +1 more source

Development of a Komagataella phaffii-based expression system for high-activity anti-SARS-CoV-2 neutralizing antibodies

AMB Express
The growing need for rapid and cost-effective antibody production highlights the potential of Komagataella phaffii (syn. Pichia pastoris) as an alternative to mammalian systems.
Xueqin Liu, Qiaoli Lang, Nan Huang, Xiaoyan You, Yuchun Ding, Meng Wu, Liangpeng Ge, Xi Yang   +7 more
doaj   +1 more source

Transgenic Chickens Expressing the 3D8 Single Chain Variable Fragment Protein Suppress Avian Influenza Transmission

Scientific Reports, 2017
The 3D8 single chain variable fragment (scFv) is a mini-antibody that causes unusual sequence-independent nuclease activity against all types of nucleic acids.
Sung June Byun, Seong-su Yuk, Ye-Jin Jang, Hoonsung Choi, Mi-Hyang Jeon, TO Erdene-Ochir, Jung-Hoon Kwon, Jin-Yong Noh, Jeom Sun Kim, Jae Gyu YOO, Chang-Seon Song   +10 more
doaj   +1 more source