Results 61 to 70 of about 12,357,672 (189)

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Original data-Schisandrin A

, 2023
Original data for Schisandrin ATHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
郭, 西 (via Mendeley Data)
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation

Pharmacological Research, 2021
Schisandrin B (Sch B) is the major active constituent of the traditional Chinese medicine Schisandra chinensis and has anti-inflammatory activity, but the target of Sch B remains unclear. T helper 17 (TH17) cells have been involved in the pathogenesis of many autoimmune and inflammatory diseases.
Zeyu, Ma, Gang, Xu, Yingying, Shen, Shufang, Hu, Xia, Lin, Jun, Zhou, Wei, Zhao, Jian, Liu, Jiaoli, Wang, Jufeng, Guo   +9 more
openaire   +2 more sources

Compound Ciwujia Granules Attenuate Stress‐Induced Anxiety‐ and Depression‐Like Behaviors via Inhibition of TNF‐α‐Associated Neuroinflammation in the dmPFC

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
By restoring glutamatergic neuronal activity, suppressing TNF‐related inflammatory signaling pathway, and reducing microglial overactivation in the dmPFC, CWJ ameliorated stress‐induced behavioral abnormalities. ABSTRACT Aims Compound Ciwujia Granules (CWJ) have shown antidepressant‐like effects, but the neural and molecular mechanisms underlying these
Fei Tian, Yi Li, Mengyu Dai, Yihan Guo, Bingbing Liao, Yingdan Zhang, Xin Gong, Lanying Liu, Dongdong Shi, Zhen Wang   +9 more
wiley   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

Anti‐neuroinflammaiton and antidepressant effects of Schisandrin B in mice

The FASEB Journal, 2013
Forced swimming exercise increases neuroinflammation and changes behavior thus taken as a murine depression‐like model. We investigated the effect of Schisandrin‐B (Schi‐B), one of the active components of Schisandra chinesnesis , on changing depressive behavior and neuroinflammation in mice ...
Ching‐Hua Yeh, Ming‐Wei Lin, Hui‐Ching Lin   +2 more
openaire   +1 more source

Heat shock protein 27 and 70 contribute to the protection of Schisandrin B against D-galactosamine-induced liver injury in mice [PDF]

, 2015
Schisandrin B is a hepatoprotective component isolated from a traditional Chinese herb Schisandra chinensis (Turcz.) Baill. This study determined the effect of Schisandrin B on D-galactosamine -induced liver injury and the role of Heat shock protein 27 ...
Zou, Yu, Shen, Longqing, Zhang, Jishun, Zhao, Zhibo, Li, Libo, Gao, Zhiying, Du, Xiaohui, Li, Qingyi   +7 more
core   +1 more source

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu, Yi‐Fan Gu, Jian‐Qiao Li, Yi‐Heng Li, Yu‐Hu Chen, Lin‐Hui Wang, Zi‐Ru Wang, Yi‐Cong Wang, Min Yang   +8 more
wiley   +1 more source

Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway

Artificial Cells, Nanomedicine, and Biotechnology, 2020
Schisandrin B (Sch B) and miR-101 family members play critical roles in the pathogenesis of liver fibrosis. However, the relationship between them has not been reported yet. Thus, this study aims to fill this research gap.
Wang Cuiqiong, Xu Chao, Fu Xinling, Jiang Yinyan   +3 more
doaj   +1 more source