Results 71 to 80 of about 12,357,672 (189)

Metabolic Mechanisms of Modified Lingguizhugan Decoction in Obesity and Lipid Metabolism Disorders: A Multi‐Omics Approach

Obesity Science &Practice, Volume 12, Issue 4, August 2026.
In this study, we explore the effects of Modified Lingguizhugan Decoction (MLGZGD) on obesity and lipid metabolism in mice, using a multi‐omics approach. Our results show that MLGZGD modulates gut microbiota composition, including beneficial genera like Akkermansia, and improves lipid metabolism by regulating triglyceride and phosphatidylcholine levels.
Fufu Li, Xiaoyan Liu, Ji Li, Haiyan Sun, Qingyang Han, Dong Liu, Ran Liu, Jieyu Chen, Zijun Ouyang, Mengting Liu   +9 more
wiley   +1 more source

Multi‐Omics Integration Identifies PTGS2 as a Candidate Diagnostic Biomarker and Precise Therapeutic Target Related to Schisandra chinensis for Osteoarthritis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This study used multi‐layer methods such as network pharmacology, differential expression analysis, functional enrichment and GSEA, molecular docking, single‐cell transcriptomics and virtual knockout to analyze the molecular mechanism of Schisandra chinensis (SC) in treating osteoarthritis (OA).
Lingtian Min, Yikai You, Shiqi Ren, Cheng Chen   +3 more
wiley   +1 more source

Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate

, 2011
Schisandrin B, an active ingredient isolated from the fruit of Schisandra chinensis, increased serum and hepatic triglyceride levels in mice. In the present study, the effective kinetics of schisandrin B on serum/hepatic triglyceride and total ...
Dong, Hang, Pan, Si Yuan, Yu, ZL, Bao-feng Guo, Ko, Kam Ming, Yi Zhang, Zhang, Yi, Guo, BF, Guo, Bao Feng, Pan, SY, Zhang, Y, Yi-Fan Han, Si-Yuan Pan, Kam-Ming Ko, Yu, Zhi Ling, Zhi-Ling Yu, Han, Yi Fan, Ko, KM, Fong, Wang Fun, Hang Dong, Wang-Fun Fong, Fong, WF, Dong, H, Han, YF   +23 more
core   +1 more source

Taste and odor metabolomics of Schisandra chinensis flesh and seeds: integration of sensory evaluation, electronic tongue, LC-QTOF-MS/MS, VirtualTaste, and HS-GC-IMS

Frontiers in Nutrition
BackgroundThe fruit of Schisandra chinensis is a functional berry with a long application history and a complex flavor profile.MethodsTo differentiate the flavor profiles of Schisandra chinensis flesh and seeds, an integrated analytical strategy ...
Tian-Qi Zhang, Lichao Wang, Fang-Tong Liu, Gui-Zhong Xin, Hong-Juan Hou, Jinxiu Liang, Hui Zhang, Tian-Min Wang, De-Qiang Dou, Xiaowei Zhang, Da-Chuan Zhang, Cheng Qian, Long-Jiao Cong, Ting-Guo Kang, Gui-Rong Chen, Yue-Hua Chen, Hui-Peng Song   +16 more
doaj   +1 more source

Comprehensive Phenolic Profiling and Antioxidant Evaluation of Calyx, Rind, and Edible Tissues From Non‐Astringent Persimmons (Diospyros kaki)

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Tissue‐specific phenolic profiling of non‐astringent persimmons (Fuyu and Jiro) reveals substantial differences in phytochemical composition and antioxidant potential. Persimmon calyx exhibits the highest concentrations of bioactive compounds, highlighting its potential as a valuable by‐product for functional food and nutraceutical applications ...
Huiwen Wang, Muhammad Sajid Arshad, Ayesha Siddiqa, Malik Adil Nawaz, Hafiz A. R. Suleria   +4 more
wiley   +1 more source

Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts

, 2011
The effects of schisandrin B (Sch B) and its analogs on solar irradiation-induced oxidative injury were examined in BJ human fibroblasts. Sch B and schisandrin C (Sch C) increased cellular reduced glutathione (GSH) level and protected against solar ...
Yan, Chung Wai, Lam, Philip Y., Ko, Kam Ming, Chiu, Po Yee   +3 more
core   +1 more source

Computational evaluation of efflux pump homologues and lignans as potent inhibitors against multidrug-resistant Salmonella typhi.

PLoS ONE
Typhoid fever, caused by Salmonella enterica serovar typhi, presents a substantial global health threat, particularly in regions with limited healthcare infrastructure. The rise of multidrug-resistant strains of S.
Iqra Shafique, Mehak Rafiq, Nosheen Fatima Rana, Farid Menaa, Fatemah Almalki, Alya Aljuaid, Sulaiman Mohammed Alnasser, Amenah S Alotaibi, Madahiah Bint E Masood, Tahreem Tanweer   +9 more
doaj   +1 more source

Gomisin G Inhibits Pancreatic Cancer Cell Growth by Promoting YAP Degradation

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study evaluated the inhibitory effect of Gomisin G, a natural dibenzocyclooctadiene lignan isolated from the fruit of Schisandra chinensis (Turcz.) Baill., on pancreatic cancer cell growth. We found that Gomisin G activated LATS1 kinase and promoted YAP phosphorylation.
Lan Li, Jiayu Chen, Jiayi Shao, Lingxiao Ye, Shuya He, Ju Huang, Licai He, Jiawei Cao, Haihua Gu, Guang Wu   +9 more
wiley   +1 more source

Dibenzocyclooctadiene Lignans from Fructus Schisandrae Chinensis Improve Glucose Uptake in vitro

Natural Product Communications, 2010
Glucose uptake assay-guided fractionations of the methanol extract of Schisandra chinensis led to the isolation of the dibenzocyclooctadiene lignans: gomisin J (1), gomisin N (2), wuweizisu B (3), wuweizisu C (4), gomisin C (5), gomisin D (6 ...
Jing Zhang, Lei Ling Shi, Yi Nan Zheng
doaj   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source