Results 71 to 80 of about 2,730 (205)

Progress on the Protective Effect and the Mechanism of Chinese Medicine Injection and Chinese Medicine Monomeric Small Molecules on Sepsis‐Related Liver Injury

open access: yesGut Medicine, Volume 2, Issue 1, Page 40-57, March 2026.
ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese ...
Xiang Yunsheng, Yan Yumeng
wiley   +1 more source

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy. [PDF]

open access: yes, 2019
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental signaling event that plays a critical role in regulating tissue development and maintaining homeostasis, the dysregulation of which contributes to various diseases.
Chen, Lin   +5 more
core  

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

open access: yesOrgan Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

Content of adaptogens in vegetable Schizandra chinensis [PDF]

open access: yes, 2013
Tato diplomová práce se zabývá obsahem adaptanogenů v rostlině Schizandra chinensis. Teoretická část se zabývá rostlinou Schizandra chinensis, jejím výskytem, vlastnostmi, využitím a pěstováním.
Kozáková, Soňa
core  

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

open access: yes, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G.   +4 more
core   +1 more source

Yixiao Formula Suppresses Myocardial Fibrosis Through UpregulatingmiR‐133a and Downregulating TGF‐β/Smads Signal Molecules

open access: yesJournal of Diabetes Research, Volume 2026, Issue 1, 2026.
Background Yixiao formula (YXF), a traditional Chinese herbal medicine, has demonstrated clinical efficacy in alleviating symptoms of diabetic cardiomyopathy (DCM). The therapeutic mechanism underlying YXF′s effects on DCM remains poorly understood. Myocardial fibrosis is a key pathogenic mechanism in DCM, and previous studies have indicated that miR ...
Qiyao Zhao   +11 more
wiley   +1 more source

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

open access: yesDrug Design, Development and Therapy, 2018
Jisheng Ran,* Chiyuan Ma,* Kai Xu,* Langhai Xu, Yuzhe He, Safwat Adel Abdo Moqbel, Pengfei Hu, Lifeng Jiang, Weiping Chen, Jiapeng Bao, Yan Xiong, Lidong Wu Department of Orthopedic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang ...
Ran J   +11 more
doaj  

Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation [PDF]

open access: yes, 2017
Additional file 1. Supplemental information of ULP-SeNPs concerns their stability in physiological solutions, uptake by BMDMs and effect on NF-κB ...
Chenghui Zhu   +9 more
core   +2 more sources

Molecular Mechanisms Underlying Sishen Pill Treating Depression‐Related Gastritis Based on Network Pharmacology and Experimental Verification

open access: yesJournal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Background Sishen Pill (SSW) has been demonstrated to be effective in neurological and gastrointestinal disorders, while it is less emphasized in depression‐related gastritis. Methods Network pharmacology and molecular docking were performed to identify the hub targets of SSW and the underlying mechanisms in the therapy of depression‐related gastritis.
Siyi Li   +7 more
wiley   +1 more source

Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway

open access: yesArtificial Cells, Nanomedicine, and Biotechnology, 2020
Schisandrin B (Sch B) and miR-101 family members play critical roles in the pathogenesis of liver fibrosis. However, the relationship between them has not been reported yet. Thus, this study aims to fill this research gap.
Wang Cuiqiong   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy