Results 91 to 100 of about 128,417 (336)

The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration [PDF]

, 2015
NMDA Receptors (NMDA-Rs) are ionotropic glutamate receptors, which associate with LDL Receptor-related Protein-1 (LRP1) to trigger cell-signaling in response to protein ligands in neurons.
Campana, W. Marie, Gonias, Steven L., Lam, Michael S, Mantuano, Elisabetta, Shibayama, Masataka   +4 more
core   +2 more sources

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

The efficacy of PDE5 inhibitors in diabetic patients

Andrology, Volume 11, Issue 2, Page 245-256, February 2023., 2023
Abstract Background Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven their efficacy in treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain the first‐line therapeutic option.
Agnieszka Swiecicka
wiley   +1 more source

Role of Laminins in the Development of the Peripheral Nervous System [PDF]

, 2007
To investigate the function of laminins in peripheral nerve development, the laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin chains known to be expressed ...
Yu, Wei-Ming
core   +1 more source

Cell autonomy of the mouse claw paw mutation. [PDF]

, 2004
Mice homozygous for the autosomal recessive mutation claw paw (clp) are characterized by limb posture abnormalities and congenital hypomyelination, with delayed onset of myelination of the peripheral nervous system but not the central nervous system ...
Aguayo, Archelos, Bermingham, Bermingham, Boylan, Brill, Bunge, Charnas, Chen, de Waegh, Del Torto, Drachman, Drachman, Du Plessis, Feltri, Fields, Ghazvini, Ghislain, Gillespie, Goldman, Hageman, Hall, Henry, Jacobson, Jaegle, Jaegle, Jessen, Jessen, Jessen, Koszowski, Matthews, Moessinger, Niemann, Parkinson, Parmantier, Polizzi, Rushton, Saito, Scaravilli, Scherer, Scherer, Seitz, Sherman, Suter, Thomas, Topilko, Webster   +46 more
core   +3 more sources

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

NF2 is Essential for Human Endoderm Development

Advanced Science, EarlyView.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression

Frontiers in Cellular Neuroscience, 2019
Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75NTR has been identified as a positive modulator for Schwann
Nádia P. Gonçalves, Nádia P. Gonçalves, Simin Mohseni, Marwa El Soury, Maj Ulrichsen, Mette Richner, Junhua Xiao, Rhiannon J. Wood, Olav M. Andersen, Elizabeth J. Coulson, Stefania Raimondo, Simon S. Murray, Christian B. Vægter, Christian B. Vægter   +13 more
doaj   +1 more source

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]

, 2016
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J., Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Lane, Fiona M., Powis, Rachael A., Sherman, Diane L., Shorrock, Hannah K., Zheng, Yinan   +9 more
core   +3 more sources

Progress and Perspectives in 2D Piezoelectric Materials for Piezotronics and Piezo‐Phototronics

Advanced Science, EarlyView.
This review examines advancements in 2D materials, focusing on their applications in piezotronics and piezo‐phototronics. It discusses key materials like TMDs, h‐BN, and phosphorene, highlighting their unique mechanical, electronic, and optical properties.
Fengyi Pang, Pin Zhao, Hyeon Yeong Lee, Dae‐Jin Kim, Xiangchun Meng, Yong Soo Cho, Sang‐Woo Kim   +6 more
wiley   +1 more source