Results 161 to 170 of about 106,917 (289)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

Impact of glycemic variability on early detection of sudomotor dysfunction: Implications for early intervention and personalized treatment

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background This study investigates the impact of glycemic variability on sudomotor dysfunction in type 2 diabetes mellitus. Methods A total of 206 type 2 diabetes mellitus patients and 34 healthy controls were included. Sweat function (SF) was assessed using electrochemical conductance of hands (HESC) and feet (FESC).
Yang Ou, Xiao‐feng Hu, Zhi Liang, Xiao‐hui Zhang, Yi‐kun Zhou   +4 more
wiley   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source

Schwann cell p75 neurotrophin receptor modulates small fiber degeneration in diabetic neuropathy

, 2020
Nádia Pereira Gonçalves, Sara E. Jager, Mette Richner, Simon S. Murray, Simin Mohseni, Troels S. Jensen, Christian Bjerggaard Vægter   +6 more
openalex   +2 more sources

Schwann Cells Promote Prevascularization and Osteogenesis of Tissue-engineered Bone via Bone Marrow Mesenchymal Stem Cell-derived Endothelial Cells [PDF]

, 2020
Xinxin Zhang, Xiaorui Jiang, Shan Jiang, Xiyu Cai, Guoxian Pei   +4 more
openalex   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

A Schwann cell–enriched circular RNA circ‐Ankib1 regulates Schwann cell proliferation following peripheral nerve injury [PDF]

, 2019
Susu Mao, Shanshan Zhang, Shuoshuo Zhou, Tao Huang, Wei Feng, Xiaosong Gu, Bin Yu   +6 more
openalex   +1 more source

Pigmented Birthmarks and Spinal Neurofibromas in KRAS Mosaicism—Not to Be Confused With NF1

Pediatric Dermatology, EarlyView.
ABSTRACT We report a child presenting with pigmentary skin lesions and spinal neurofibromas who was diagnosed molecularly with KRAS mosaicism. We review the previous literature of two cases of congenital skin lesions and neurofibromas and spinal nerve root hypertrophy caused by KRAS variants and highlight this presentation as an important differential ...
Karina M. Forde, Nicole Knöpfel, Ulrike Loebel, Veronica A. Kinsler   +3 more
wiley   +1 more source

The Proteolipid Protein 1 Promoter Drives Reporter Gene Expression in Corneal Schwann Cells

, 2020
Paola Bargagna‐Mohan, Connor Treadwell, Katherine S. Given, Wendy B. Macklin, Royce Mohan   +4 more
openalex   +1 more source