Results 41 to 50 of about 20,344 (273)

Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]

, 2017
Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita, He, Guangxu, Lim, Joohyun, Long, Fanxin, Ni, Jiangdong, Shi, Yu   +5 more
core   +3 more sources

Sclerostin and Cardiovascular Disease

Current Osteoporosis Reports, 2023
Abstract Purpose of Review The role of wnt signalling in atherogenesis raises the possibility that the wnt inhibitor, sclerostin, provides a natural defence to this process, and that anti-sclerostin antibodies might increase the risk of atherosclerosis and associated conditions such as CVD.
openaire   +3 more sources

The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6 [PDF]

Open Biology, 2016
The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling.
V. Boschert, C. Frisch, J. W. Back, K. van Pee, S. E. Weidauer, E.-M. Muth, P. Schmieder, M. Beerbaum, A. Knappik, P. Timmerman, T. D. Mueller   +10 more
doaj   +1 more source

Sclerostin: From Molecule to Clinical Biomarker

International Journal of Molecular Sciences, 2022
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling. Osteocytes are differentiated osteoblasts that form a vast and highly complex communication network and orchestrate osteogenesis in response to both mechanical and ...
Ahmed Omran, Diana Atanasova, Filip Landgren, Per Magnusson   +3 more
openaire   +3 more sources

Sclerostin [PDF]

Clinical Journal of the American Society of Nephrology, 2011
Renal osteodystrophy (ROD) is one of the three components of chronic kidney disease–mineral and bone disorder (CKD-MBD) ([1][1]). Patients with CKD may develop various types of bone disease, spanning the spectrum of extreme situations such as severe osteitis fibrosa, osteomalacia, mixed ...
Tilman B, Drüeke, Marie-Hélène, Lafage-Proust   +1 more
openaire   +2 more sources

Antitumor Effect of Sclerostin against Osteosarcoma [PDF]

Cancers, 2021
Various risk factors and causative genes of osteosarcoma have been reported in the literature; however, its etiology remains largely unknown. Bone formation is a shared phenomenon in all types of osteosarcomas, and sclerostin is an extracellular soluble factor secreted by osteocytes that prevents bone formation by inhibiting the Wnt signaling pathway ...
Hirokazu Ideta, Kazushige Yoshida, Masanori Okamoto, Jun Sasaki, Munehisa Kito, Kaoru Aoki, Yasuo Yoshimura, Shuichiro Suzuki, Atsushi Tanaka, Akira Takazawa, Hisao Haniu, Takeshi Uemura, Takashi Takizawa, Atsushi Sobajima, Takayuki Kamanaka, Jun Takahashi, Hiroyuki Kato, Naoto Saito   +17 more
openaire   +2 more sources

Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]

, 2014
The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
core   +3 more sources

Sclerostin expression in skeletal sarcomas [PDF]

Human Pathology, 2016
Sclerostin (SOST) is an extracellular Wnt signaling antagonist which negatively regulates bone mass. Despite this, the expression and function of SOST in skeletal tumors remain poorly described. Here, we first describe the immunohistochemical staining pattern of SOST across benign and malignant skeletal tumors with bone or cartilage matrix (n=68 ...
Shen, Jia, Meyers, Carolyn A, Shrestha, Swati, Singh, Arun, LaChaud, Greg, Nguyen, Vi, Asatrian, Greg, Federman, Noah, Bernthal, Nicholas, Eilber, Fritz C, Dry, Sarah M, Ting, Kang, Soo, Chia, James, Aaron W   +13 more
openaire   +4 more sources

The association of circulating sclerostin level with markers of bone metabolism in patients with thyroid dysfunction [PDF]

Journal of Medical Biochemistry, 2020
Background: The aim of this study was to compare serum sclerostin concentrations in patients with thyroid dysfunction with euthyroid control subjects and to assess the relationship between sclerostin and markers of bone metabolism (osteocalcin and beta ...
Mihaljević Olgica, Živančević-Simonović Snežana, Lučić-Tomić Aleksandra, Živković Irena, Minić Rajna, Mijatović-Teodorović Ljiljana, Jovanović Zorica, Anđelković Marija, Stanojević-Pirković Marijana   +8 more
doaj  

Bone Sclerostin and Dickkopf-related protein-1 are positively correlated with bone mineral density, bone microarchitecture, and bone strength in postmenopausal osteoporosis

BMC Musculoskeletal Disorders, 2021
Background Wnt-catenin signaling antagonists sclerostin and dickkopf-related protein-1 (Dkk-1) inhibit bone formation and are involved in the pathogenesis of postmenopausal osteoporosis (PO). However, the association between sclerostin and Dkk-1 and bone
Jia Peng, Zhang Dong, Zhang Hui, Wang Aifei, Deng Lianfu, Xu Youjia   +5 more
doaj   +1 more source