Results 71 to 80 of about 25,148 (309)

Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]

, 2015
Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo, Heijsters, Guido, Politis, Constantinus, Salem, Ahmed Sobhy, Schepers, Serge, Van Slycke, Sarah, Vrielinck, Luc   +6 more
core   +3 more sources

SOST/Sclerostin impairs the osteogenesis and angiogesis in glucocorticoid-associated osteonecrosis of femoral head

Molecular Medicine
Glucocorticoid-associated osteonecrosis of the femoral head (GA-ONFH) is a progressive bone disorder which frequently results in femoral head collapse and hip joint dysfunction. Sclerostin (SOST) is principally secreted by osteocytes in bone and plays an
Junming Huang, Tianle Ma, Chen-zhong Wang, Zhe Wang, Xinyuan Wang, B. Hua, Chang Jiang, Zuo-Qin Yan   +7 more
semanticscholar   +1 more source

Osteoporosis Treatment with Anti-Sclerostin Antibodies—Mechanisms of Action and Clinical Application

Journal of Clinical Medicine, 2021
Osteoporosis is characterized by reduced bone mass and disruption of bone architecture, resulting in increased risk of fragility fractures and significant long-term disability.
M. Rauner, H. Taipaleenmäki, E. Tsourdi, E. Winter   +3 more
semanticscholar   +1 more source

Association of total and bioactive serum sclerostin levels with bone metabolism in type 2 diabetes mellitus

Journal of Clinical & Translational Endocrinology
Background: Sclerostin has been associated with decreased bone turnover in patients with type 2 diabetes mellitus (T2DM). The relationship with bone turnover markers (BTMs) and bone mineral density (BMD) remains unclear.
Cyril Traechslin, Lilian Sewing, Sandra Baumann, Leticia Grize, Janina Vavanikunnel, Marius Kraenzlin, Christoph Henzen, Christian Meier   +7 more
doaj   +1 more source

Identification of a DNA aptamer that inhibits sclerostin's antagonistic effect on Wnt signalling [PDF]

, 2011
Sclerostin is an extracellular negative regulator of bone formation that is a recognized therapeutic target for osteoporosis therapy. In the present study, we performed DNA aptamer selection against sclerostin, then characterized aptamer-sclerostin ...
Chan, C, Leung, CM, Shum, KT, Tanner, JA
core   +1 more source

Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential

Molecular Therapy: Nucleic Acids
Osteogenesis imperfecta (OI) is a rare genetic disease characterized by bone fragility and bone formation. Sclerostin could negatively regulate bone formation by antagonizing the Wnt signal pathway, whereas it imposes severe cardiac ischemic events in ...
Amu Gubu, Yuan Ma, Sifan Yu, Huarui Zhang, Zefeng Chen, Shuaijian Ni, Razack Abdullah, Huan Xiao, Yihao Zhang, Hong Dai, Hang Luo, Yuanyuan Yu, Luyao Wang, Hewen Jiang, Ning Zhang, Yuan Tian, Haitian Li, Aiping Lu, Baoting Zhang, Ge Zhang   +19 more
semanticscholar   +1 more source

The roles of sclerostin and irisin on bone and muscle of orchiectomized rats

BMC Musculoskeletal Disorders, 2022
Background The reduction in androgen level gives rise to a decrease in bone mineral density (BMD) and muscle strength, but the exact mechanisms are unclear.
Bing-na Zhou, Qian Zhang, Xiao-yun Lin, Jing Hu, Di-chen Zhao, Yan Jiang, X. Xing, Mei Li   +7 more
semanticscholar   +1 more source

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing [PDF]

, 2015
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia ...
Carriero, A, Chang, Y M, Farquharson, C, Houston, D A, Javaheri, B, Kazeruni, B N, Millan, J L, Oldknow, K J, Pitsillides, A A, Salmon, P, Shefelbine, S, Staines, K A   +11 more
core   +4 more sources

Decreased Serum Level of Sclerostin in Older Adults with Sarcopenia

Endocrinology and Metabolism, 2022
Background Although muscles and bones interact with each other through various secretory factors, the role of sclerostin, an osteocyte-secreted factor, on muscle metabolism has not been well studied.
Seong Hee Ahn, H. Jung, Eunju Lee, J. Baek, Il-Young Jang, S. Park, Jin-Young Lee, E. Choi, Y. Lee, S. Hong, B. Kim   +10 more
semanticscholar   +1 more source

Novel actions of sclerostin on bone [PDF]

Journal of Molecular Endocrinology, 2019
The discovery that two rare autosomal recessive high bone mass conditions were caused by the loss of sclerostin expression prompted studies into its role in bone homeostasis. In this article, we aim to bring together the wealth of information relating to sclerostin in bone though discussion of rare human disorders in which sclerostin is reduced or ...
Gill, Holdsworth, Scott J, Roberts, Hua Zhu, Ke   +2 more
openaire   +2 more sources