Results 71 to 80 of about 288,820 (252)

Scorpions from the primeval subgenus Archaeotityus produce putative homologs of Tityus serrulatus toxins active on voltage-gated sodium channels

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus ...
A Borges, MJ Jowers, S Bónoli, L De Sousa   +3 more
doaj   +1 more source

Turning a Scorpion Toxin into an Antitumor Miniprotein [PDF]

Journal of the American Chemical Society, 2008
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53 and are important molecular targets for anticancer therapy. Grafting four residues of p53 critical for MDM2/MDMX binding to the N-terminal alpha-helix of BmBKTx1, a scorpion toxin isolated from the venom of the Asian scorpion Buthus ...
Chong, Li, Min, Liu, Juahdi, Monbo, Guozhang, Zou, Changqing, Li, Weirong, Yuan, Davide, Zella, Wei-Yue, Lu, Wuyuan, Lu   +8 more
openaire   +2 more sources

A Review on Ginkgo biloba: Nutritional Profile, Toxicity, and Its Therapeutic Potential in Stroke Management

eFood, Volume 7, Issue 1, February 2026.
Stroke is a neurological impairment caused by vascular injury of the central nervous system, and globally, stroke is ranked as the second most common cause of death and disability. Numerous risk factors, disease processes, and mechanisms can contribute to stroke, which is not a single disease. G.
Ali Ikram, Farhang Hameed Awlqadr, Hamna Tayyab, Mamoona Shehzadi, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Ahmadullah Zahir   +6 more
wiley   +1 more source

Assembling an arsenal, the scorpion way

BMC Evolutionary Biology, 2008
Background For survival, scorpions depend on a wide array of short neurotoxic polypeptides. The venoms of scorpions from the most studied group, the Buthida, are a rich source of small, 23–78 amino acid-long peptides, well packed by either three or four ...
Mishmar Dan, Bar-Shalom Adi, Kozminsky-Atias Adi, Zilberberg Noam   +3 more
doaj   +1 more source

Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2

Cell & Bioscience, 2014
BackgroundThe human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG channel derived from scorpion Mesobuthus
Youtian Hu, Jun Hu, Tian Li, Jingjing Wei, Jing Feng, Yimei Du, Z. Cao, Wenxin Li, Yingliang Wu   +8 more
semanticscholar   +1 more source

Phase II clinical trial of nirogacestat in patients with relapsed ovarian granulosa cell tumours

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence suggests NOTCH activation is among the survival and proliferation pathways interacting with FOXL2 c.402C > G (p.Cys134Trp) mutation in granulosa cell tumours (GCT). This Phase II clinical trial of nirogacestat in GCT achieved its enrolment target in < 1 year and primary analysis within 2 years.
Rachel N. Grisham, Elizabeth Hopp, Kathryn Pennington, Robert Holloway, Robert M. Wenham, Pawel Blecharz, Lauren Dockery, Koji Matsuo, Ritu Salani, Mariusz Bidzinski, Patricia Braly, Paul Celano, Thomas Reid, Shelly Seward, Jocelyn Lewis, Mark Johnson, Robert DuBose, Sarah Ahn, Shinta Cheng, Carmelita Alvero, Panagiotis A. Konstantinopoulos   +20 more
wiley   +1 more source

A novel tumor-activated ALA fusion protein for specific inhibition on the growth and invasion of breast cancer cells MDA-MB-231

Drug Delivery, 2017
Objective: The aim of this research was to develop a novel ALA fusion protein for target to the malignant cells surface with high uPAR expression and locally release of the scorpion toxin AGAP in an uPA-cleavable manner.
Xiufeng Liu, Xintong Liu, Suwen Sunchen, Meixia Liu, Chen Shen, Juanjuan Wu, Wanli Zhao, Boyang Yu, Jihua Liu   +8 more
doaj   +1 more source

A Deeper Examination of Thorellius atrox Scorpion Venom Components with Omic Technologies

Toxins, 2017
This communication reports a further examination of venom gland transcripts and venom composition of the Mexican scorpion Thorellius atrox using RNA-seq and tandem mass spectrometry.
Teresa Romero-Gutierrez, Esteban Peguero-Sanchez, Miguel A. Cevallos, Cesar V. F. Batista, Ernesto Ortiz, Lourival D. Possani   +5 more
doaj   +1 more source

Engineering Gossypol‐Free Cottonseeds for Future Global Food Security and Agricultural Sustainability

Food Frontiers, Volume 7, Issue 1, January 2026.
This study depicting the role of transcriptomics, RNA interference (RNAi), and CRISPR/Cas9 technologies in the breeding of glandless cottonseed and glanded cotton tissues. This approach demonstrates the potential of cotton as a dual‐purpose crop, serving both the fiber industry and as a sustainable food and feed source.
Teame Gereziher Mehari, Muhammad Yousaf Shani, Junfeng Tang, Hui Fang, Muhammad Jawad Umer, Fang Liu, Kai Wang, Dengbing Yao, Muhammad K. R. Khan, Baohua Wang   +9 more
wiley   +1 more source

A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii

Toxins, 2016
Scorpion venom is deemed to contain many toxic peptides as an important source of natural compounds. Out of the two hundred proteins identified in Mesobuthus martensii (M. martensii), only a few peptide toxins have been found so far.
Ning Luan, W. Shen, Jie Liu, Bo Wen, Zhilong Lin, Shilong Yang, R. Lai, Siqi Liu, M. Rong   +8 more
semanticscholar   +1 more source