Results 71 to 80 of about 556,612 (159)

Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. [PDF]

PLoS ONE, 2013
BACKGROUND: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels.
Zongyun Chen, Fan Luo, Jing Feng, Weishan Yang, Danyun Zeng, Ruiming Zhao, Zhijian Cao, Maili Liu, Wenxin Li, Ling Jiang, Yingliang Wu   +10 more
doaj   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Molecular cloning and biochemical characterization of the first Na+-channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom

, 2013
Due to the medical importance played in Turkey by stings of the scorpion Androctonus crassicauda, its venom has been studied with more attention.
Restano-Cassulini, Rita, Possani, Lourival D., Coronas-Valderrama, Fredy I., Quintero-Hernandez, Veronica, Corzo, Gerardo, ÇALIŞKAN, FİGEN   +5 more
core   +1 more source

Recombinant Expression and Functional Characterization of Martentoxin: A Selective Inhibitor for BK Channel (α + β4)

Toxins, 2014
Martentoxin (MarTX), a 37-residue peptide purified from the venom of East-Asian scorpion (Buthus martensi Karsch), was capable of blocking large-conductance Ca2+-activated K+ (BK) channels.
Jie Tao, Zhi Lei Zhou, Bin Wu, Jian Shi, Xiao Ming Chen, Yong Hua Ji   +5 more
doaj   +1 more source

Pond frog as a predator of hornet workers: High tolerance to venomous stings

Ecosphere, Volume 16, Issue 12, December 2025.
Abstract Some animals use stingers to repel attackers, and some predators have evolved tolerance to such stings, enabling them to consume venomous prey. For example, social wasps, such as hornets, use modified ovipositors as venomous stingers to inject venom, which can cause intense pain in humans.
Shinji Sugiura
wiley   +1 more source

A Cell‐Penetrating Scorpion Venom Peptide Disrupts the HSP90β‐PPARα Interaction to Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease

iMetaMed, Volume 1, Issue 2, December 2025.
In MASLD, increased HSP90β interacts with PPARα, thereby inhibiting PPARα activation via the inhibition of its nuclear translocation. BmK Tx‐2, a cell‐penetrating peptide from Buthus martensii Karsch scorpion venom, enters hepatocytes via macropinocytosis and escapes endosomes to bind HSP90β.
Erjin Xu, Wuguang Lu, Yonggen Chen, Ming Sang, Jiao Chen, Xueting Cai, Wenhao Xu, Yuxin Zhang, Zhiheng Wang, Feng Zhang, Peng Cao   +10 more
wiley   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

JOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Sexual dimorphism in venom gland morphology in a sexually stinging scorpion [PDF]

, 2017
Males of several scorpion species possess bigger telsons than females. In at least some of these species, males repeatedly sting females during mating.
Graber, F, Kropf, Christian, Lenka Sentenská, Christian Kropf, Sentenska, Lenka, Miguel Richard, Richard, Miguel, Franziska Graber   +7 more
core   +2 more sources

Structural similarities reveal an expansive conotoxin family with a two‐finger toxin fold

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Muhammad Saad Khilji, Celeste M. Hackney, Thomas L. Koch, Arik J. Hone, Aymeric Rogalski, Maren Watkins, Jortan Tun, J. Michael McIntosh, Baldomero Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +11 more
wiley   +1 more source

Antigenic Cross-Reactivity Anti-Birtoxin Antibody against Androctonus crassicauda Venom

Journal of Arthropod-Borne Diseases, 2015
Background: Antivenom is still widely used in the treatment of envenomation as there are no vaccines or other effective agents available against animal venoms.
SuhandanAdigüzel Van-Zoelen, Ozcan Ozkan, Bora Inceoglu   +2 more
doaj