Results 61 to 70 of about 556,612 (159)

Scorpion Venom: Detriments and Benefits

, 2020
Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming.
Laustsen, Andreas H., Lídia Argemi, Karla C. F. Bordon, Manuela B. Pucca, Shirin Ahmadi, Arantes, Eliane C., Cerni, Felipe A., Pucca, Manuela B., Knerr, Julius M, Çalışkan, Figen, Ahmadi, Shirin, Andreas H. Laustsen, Felipe A. Cerni, Argemi, Lídia, Julius M. Knerr, Figen Çalışkan, Bordon, Karla C. F., Eliane C. Arantes, Knerr, Julius M.   +18 more
core   +1 more source

Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide [PDF]

, 2018
In this study, a novel scorpion venom‐derived peptide named Gonearrestide was identified in an in‐house constructed scorpion venom library through a combination of high‐throughput NGS transcriptome and MS/MS proteome platform.
Mahadevappa, Ravikiran, Hang Fai Kwok, Lilin Ge, Bin Li, Kwok, Hang Fai, Ravikiran Mahadevappa, Xi, Xinping, Li, Bin, Peng Lyu, Chris Shaw, Xinping Xi, Lyu, Peng, Shaw, Chris, Ge, Lilin   +13 more
core   +1 more source

Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki

Cell & Bioscience, 2017
Background Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibitors.
Yan Zou, Feng Zhang, Yaxian Li, Yuanfang Wang, Yi Li, Zhengtao Long, Shujuan Shi, Li Shuai, Jiukai Liu, Zhiyong Di, Shijin Yin   +10 more
doaj   +1 more source

Extraction and quantification of antivenomous antibodies in chicken eggs against scorpion venom

, 2023
: Avian-derived IgY is thought to be the best therapy for scorpion bites concerning low-level side effects. The present study analyzed a hypothesis about the neutralization of scorpion venom Androcotonus australis through antibodies produced in the egg ...
Aleem Ahmed Khan, Mehvish Andleeb
core   +1 more source

Parabutoporin, a cationic amphipathic peptide from scorpion venom: much more than an antibiotic [PDF]

, 2009
Parabutoporin (PP) from the South African scorpion Parabuthus schlechteri is a 45-mer lysine-rich and cysteine-free peptide. At micromolar concentrations it has antimicrobial effects against G+ and G- bacteria and is antifungal as well.
Willems, Jean, Verdonck, Fons, Remijsen, Quinten   +2 more
core  

Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats [PDF]

Brazilian Journal of Medical and Biological Research
Scorpion venom is a Chinese medicine for epilepsy treatment, but the underlying mechanism is not clear. Scorpion venom heat-resistant peptide (SVHRP), a peptide isolated from the venom of Buthus martensii Karsch, has an anti-epileptic effect by reducing ...
Qizuan Chen, Pengfan Yang, Qiao Lin, Jiasheng Pei, Yanzeng Jia, Zhonghui Zhong, Shousen Wang   +6 more
doaj   +2 more sources

Protective Role of Holothuria leucospilota Extract Against Amyloid‐β Toxicity via Autophagy and Antioxidant Mechanisms in Caenorhabditis elegans Model

Oxidative Medicine and Cellular Longevity, Volume 2026, Issue 1, 2026.
Alzheimer’s disease (AD) is a major global health challenge characterized by cognitive decline and neuronal degeneration driven by amyloid‐β (Aβ) aggregation and oxidative stress. Given the limited efficacy and adverse effects of current pharmacological therapies, food‐derived bioactive compounds have gained increasing attention as potential preventive
Chanathip Kamonnat, Salinthip Thongdechsri, Pichnaree Kraokaew, Nakorn Niamnont, Prasert Sobhon, Krai Meemon, Lidija Milkovic   +6 more
wiley   +1 more source