Results 51 to 60 of about 556,612 (159)

Integrative transcriptomic and machine learning approaches reveal candidate genes for silk and venom production in Bibionomorpha (Diptera)

Insect Molecular Biology, EarlyView.
Multi‐species transcriptomics and deep learning identified candidate genes associated with silk and venom production in Bibionomorpha. Venom‐associated genes were enriched in proteases, inhibitors and pore‐forming proteins, whereas silk‐related genes showed chitin‐binding and peritrophin domains. Integrating co‐expression networks, machine learning and
Daniel Kenji Matuo, João Alfredo Teodoro, Danilo T. Amaral   +2 more
wiley   +1 more source

Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential

Toxins
Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases.
Kaiyun Xin, Ruize Sun, Wanyang Xiao, Weijie Lu, Chenhui Sun, Jietao Lou, Yanyan Xu, Tianbao Chen, Di Wu, Yitian Gao   +9 more
doaj   +1 more source

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold

Bioscience Reports, 2013
The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new scorpion venom-derived K+ channel toxin (named λ-MeuKTx-1) with an ICK fold through gene ...
Bin Gao, Peta J. Harvey, David J. Craik, Michel Ronjat, Michel De Waard, Shunyi Zhu   +5 more
doaj   +1 more source

Spinal Anesthesia Failure Following Wasp Envenomation: A Case Series of Two Patients

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Spinal anesthesia is highly effective, and complete failure in healthy patients is rare. Wasp venom contains neuroactive peptides capable of modifying sodium‐channel function and inducing neuroinflammation, but its impact on neuraxial anesthesia has not been previously reported. We describe two healthy ASA I males who developed complete spinal
Ammir Abuzahra, Mohammad Maraqah, Saja Atawneh, Rasmiya Qawasmi, Mohammad Rabaee, Shaimaa Sweity, Osama Ewidat, Nuha Riyad, Abdulhamid Mujahed   +8 more
wiley   +1 more source

Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin [PDF]

, 2019
Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can be used as prototypes for the design of new drugs.
Alessandra, Daniele-Silva,, Enéas De, Carvalho,, Bruno, Amorim-Carmo,, Arnóbio Antônio Da, Silva-Júnior,, Sérgio R.B., Silva,, Norberto K., Monteiro,, Elizabeth Cristina Gomes, Santos,, Matheus De Freitas, Fernandes-Pedrosa,, Allanny Alves, Furtado,, Adriana M.S., Parente,, Johny W.F., Oliveira,, Silva, MS, Matheus F. Fernandes-Pedrosa, Bruno Amorim-Carmo, Sérgio R. B. Silva, Adriana M. S. Parente, Arnóbio A. Silva-Júnior, Alessandra Daniele-Silva, Elizabeth C. G. Santos, Marcelo S. Silva, Johny W. F. Oliveira, Norberto K. Monteiro, Allanny A. Furtado, Eneas Carvalho   +23 more
core   +1 more source

Experimental Study on Anti Scorpion Venom potential of Paravatadi Agada of Ayurveda in Indian Red Scorpion Venom (Mesobuthus tamulus) [PDF]

, 2020
Background: Scorpion sting is a frequent event in tropical and subtropical countries. The objective of this study is to evaluate Efficacy of Paravatadi Agada on Indian Red Scorpion Venom (Mesobuthus Tamulus). Materials and Methods: PA was prepared as per
Rajput, Dhirajsing, Deshmukh, Sunil, Chalakh, Sonali, Sonali Chalakh, Sunil Deshmukh, Dhirajsing Rajput   +5 more
core   +1 more source

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha, Richa Gill, Sergio Crovella, Haissam Abou‐Saleh, Sahar Isa Da'as   +4 more
wiley   +1 more source

Inhibitory Effect of an Acidic Peptide on the Activity of an Antimicrobial Peptide from the Scorpion Mesobuthus martensii Karsch

Molecules, 2018
Highly acidic peptides with no disulfide bridges are widely present in the scorpion venoms; however, none of them has been functionally characterized so far.
Wanxia Shi, Pengchen He, Xian-Chun Zeng, Weiwei Wu, Xiaoming Chen   +4 more
doaj   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Food Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi, Sally Kamau, Gulnaz Seitimova, Shynar Zhumagaliyeva, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +6 more
wiley   +1 more source

Old dog, new trick: Charybdotoxin as a novel ryanodine receptor blocker

The Journal of Physiology, Volume 604, Issue 17, Page 7246-7263, 1 September 2026.
Abstract figure legend The peptide toxin charybdotoxin (ChTx) from the scorpion Leiurus quinquestriatus was tested on single‐channel currents of the ryanodine receptor incorporated into planar lipid bilayers. The structure–function relationship of ChTx was investigated using toxin variants generated by isosteric substitutions of the basic amino acids ...
Zsuzsanna Édua Magyar, Judit Hevesi, Frigyes Mészáros, Zsolt Bozsó, János Szolomájer, Gábor Tóth, György Panyi, Péter Enyedi, Zoltán Varga, Zoltán Pethő, János Almássy   +10 more
wiley   +1 more source