Results 1 to 10 of about 5,167 (220)

Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death [PDF]

Frontiers in Pharmacology, 2022
Within the last decade, several peptides have been identified according to their ability to inhibit the growth of microbial pathogens. These antimicrobial peptides (AMPs) are a part of the innate immune system of all living organisms. Many studies on their effects on prokaryotic microorganisms have been reported; some of these peptides have cytotoxic ...
Ranwa A. Elrayess, Ranwa A. Elrayess, Mahmoud E. Mohallal, Yomn M. Mobarak, Hala M. Ebaid, Sarah Haywood-Small, Keith Miller, Peter N. Strong, Mohamed A. Abdel-Rahman   +8 more
openaire   +7 more sources

Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds [PDF]

Toxins
Venom is a key evolutionary innovation of venomous organisms in the long-term process of survival adaptation. As one of the oldest arthropods, scorpions produce venom rich in bioactive peptides that also constitute a valuable pharmacological resource ...
Yun Huang, Peter Muiruri Kamau, Jiamin Wang, Mingyue Gao, Bowen Li   +4 more
doaj   +2 more sources

Antimicrobial Potential of Scorpion-Venom-Derived Peptides

Molecules
The frequent and irrational use of antibiotics by humans has led to the escalating rise of antimicrobial resistance (AMR) with a high rate of morbidity-mortality worldwide, which poses a challenge to the development of effective treatments.
Zhiqiang Xia, Lixia Xie, Bing Li, Xiangyun Lv, Hongzhou Zhang, Zhijian Cao   +5 more
doaj   +3 more sources

Beta Toxins Isolated from the Scorpion Centruroides hirsutipalpus (Scorpiones; Buthidae) Affect the Function of Sodium Channels of Mammals [PDF]

Toxins
Scorpion venom toxins are important peptides being studied for their clinical significance. These peptides act by binding to ion channels in the membrane of nerve cells, causing the symptoms associated with scorpion stings (scorpionism). They principally
Laura L. Valdez-Velazquez, Timoteo Olamendi-Portugal, Rita Restano-Cassulini, Lidia Riaño-Umbarila, Juana María Jiménez-Vargas, Fernando Zamudio, Hermenegildo Salazar-Monge, Baltazar Becerril, Lourival D. Possani   +8 more
doaj   +2 more sources

Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential [PDF]

Toxins
Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases.
Kaiyun Xin, Ruize Sun, Wanyang Xiao, Weijie Lu, Chenhui Sun, Jietao Lou, Yanyan Xu, Tianbao Chen, Di Wu, Yitian Gao   +9 more
doaj   +2 more sources

Microbiota discovered in scorpion venom. [PDF]

PLoS ONE
With low nutrient availability and presence of numerous antimicrobial peptides, animal venoms have been traditionally considered to be harsh sterile environments that lack bacteria.
Barbara Murdoch, Adam J Kleinschmit, Carlos E Santibáñez-López, Matthew R Graham   +3 more
doaj   +2 more sources

Scorpion Venom Heat-Resistant Peptide Attenuates Microglia Activation and Neuroinflammation [PDF]

Frontiers in Pharmacology, 2021
Background: Intervention of neuroinflammation in central nervous system (CNS) represents a potential therapeutic strategy for a host of brain disorders. The scorpion Buthus martensii Karsch (BmK) and its venom have long been used in the Orient to treat inflammation-related diseases such as rhumatoid arthritis and chronic pain.
Xue-Fei Wu, Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li, Shao Li   +16 more
openaire   +7 more sources

TanP: A Multifunctional Anionic Peptide From Tityus stigmurus Scorpion Venom [PDF]

Frontiers in Molecular Biosciences, 2022
Anionic peptides of scorpions are molecules rich in aspartic and/or glutamic acid residues and correspond to a class of peptides without disulfide bonds that are still little explored. TanP is a linear anionic peptide (50 amino acid residues and net charge −20) present in the venom gland of the scorpion, Tityus stigmurus, with chelating properties for ...
Menilla Maria Alves de Melo, Verônica da Silva Oliveira, Moacir Fernandes de Queiroz Neto, Weslley de Souza Paiva, Manoela Torres-Rêgo, Manoela Torres-Rêgo, Sérgio Ruschi Bergamachi Silva, Daniel de Lima Pontes, Hugo Alexandre Oliveira Rocha, Miguel Ângelo Fonseca de Souza, Arnóbio Antônio da Silva-Júnior, Matheus de Freitas Fernandes-Pedrosa   +11 more
openaire   +3 more sources

Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Pharmacological Research, 2023
Animal venom is an important evolutionary innovation in nature. As one of the most representative animal venoms, scorpion venom contains an extremely diverse set of bioactive peptides.
Zhiqiang Xia, Dangui He, Yingliang Wu, Hang Fai Kwok, Zhijian Cao   +4 more
doaj   +1 more source

Antimicrobial Activity Developed by Scorpion Venoms and Its Peptide Component

Toxins, 2022
Microbial infections represent a problem of great importance at the public health level, with a high rate of morbidity-mortality worldwide. However, treating the different diseases generated by microorganisms requires a gradual increase in acquired resistance when applying or using them against various antibiotic therapies.
Clara Andrea Rincón-Cortés, Martín Alonso Bayona-Rojas, Edgar Antonio Reyes-Montaño, Nohora Angélica Vega-Castro   +3 more
openaire   +3 more sources