Results 31 to 40 of about 5,167 (220)
Pi5 and Pi6, two undescribed peptides from the venom of the scorpion Pandinus imperator and their effects on K + -channels [PDF]
, 2018 K
Csóti, Ágota +5 more
core +1 more source
BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom
PLoS ONE, 2012 By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor that displays a signal sequence and contains four copies of BmK-YA sequences and four of His(4)-BmK-
Zhang, Yan +5 more
openaire +5 more sources
Insect-selective spider toxins targeting voltage-gated sodium channels [PDF]
, 2007 The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Nav channel gating.
Nicholson, GM
core +1 more source
Drug design, development and therapy, 2020 To date, the success of conventional chemotherapy, radiotherapy, and targeted biological therapies in cancer treatment is not satisfactory. The main reasons for such outcomes rely on low target selectivity, primarily in chemo- and radiotherapy, ineffectiveness to metastatic disease, drug resistance, and severe side effects.
Mikaelian,Arthur G +6 more
openaire +5 more sources
Exon Shuffling and Origin of Scorpion Venom Biodiversity
Toxins, 2016 Scorpion venom is a complex combinatorial library of peptides and proteins with multiple biological functions. A combination of transcriptomic and proteomic techniques has revealed its enormous molecular diversity, as identified by the presence of a ...
Xueli Wang, Bin Gao, Shunyi Zhu
doaj +1 more source
Journal of Basic and Applied Zoology, 2020 Background Scorpion venom is a very complicated mixture of various peptides/proteins which could induce toxicological and pharmacological responses.
Nahla M. Shoukry +4 more
doaj +1 more source
Biotechnological Trends in Spider and Scorpion Antivenom Development [PDF]
, 2016 Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain.
Engmark, Mikael +5 more
core +3 more sources
Trends in PharmacyAnimal venoms, especially those from scorpions, have garnered interest for their potential therapeutic uses. Scorpion venom is a complex mixture of bioactive compounds, including neurotoxins, enzymes, enzyme inhibitors, and peptides. These peptides have
Radwa Abdallnasser Amen +1 more
doaj +3 more sources
A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain. [PDF]
JOR SpineThis review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
Melrose J +4 more
europepmc +2 more sources
Antiviral activity of animal venom peptides and related compounds [PDF]
, 2017 Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense.
Mata, Élida Cleyse Gomes da Mata +3 more
core +2 more sources