Results 41 to 50 of about 5,167 (220)

Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys

Toxins, 2019
Various bioactive peptides have been identified in scorpion venom, but there are many scorpion species whose venom has not been investigated. In this study, we characterized venom components of the North African scorpion, Buthacus leptochelys, by mass ...
Yusuke Yoshimoto, Masahiro Miyashita, Mohammed Abdel-Wahab, Moustafa Sarhan, Yoshiaki Nakagawa, Hisashi Miyagawa   +5 more
doaj   +1 more source

Anticoagulant Activity of Low-Molecular Weight Compounds from Heterometrus laoticus Scorpion Venom

Toxins, 2017
Scorpion venoms are complex polypeptide mixtures, the ion channel blockers and antimicrobial peptides being the best studied components. The coagulopathic properties of scorpion venoms are poorly studied and the data about substances exhibiting these ...
Thien Vu Tran, Anh Ngoc Hoang, Trang Thuy Thi Nguyen, Trung Van Phung, Khoa Cuu Nguyen, Alexey V. Osipov, Igor A. Ivanov, Victor I. Tsetlin, Yuri N. Utkin   +8 more
doaj   +1 more source

Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides [PDF]

Antibiotics, 2017
Seven analogs of the natural, α-helix peptides IsCT1 and IsCT2—found in the venom of scorpion Opithancatus Madagascariensis—have been synthesized and tested to compare their antibacterial and hemolytic activity against natural peptides. In general, results show that increasing hydrophobicity by substituting positions 5 and 9 of the sequences with ...
de la Salud Bea, Roberto, Petraglia, Adam F., Ascuitto, Michael R., Buck, Quentin M.   +3 more
openaire   +2 more sources

Evolution Stings: The Origin and Diversification of Scorpion Toxin Peptide Scaffolds

Toxins, 2013
The episodic nature of natural selection and the accumulation of extreme sequence divergence in venom-encoding genes over long periods of evolutionary time can obscure the signature of positive Darwinian selection.
Kartik Sunagar, Eivind A. B. Undheim, Angelo H. C. Chan, Ivan Koludarov, Sergio A. Muñoz-Gómez, Agostinho Antunes, Bryan G. Fry   +6 more
doaj   +1 more source

The Enzymatic Core of Scorpion Venoms

Toxins, 2022
Enzymes are an integral part of animal venoms. Unlike snakes, in which enzymes play a primary role in envenomation, in scorpions, their function appears to be ancillary in most species.
Gustavo Delgado-Prudencio, Jimena I. Cid-Uribe, J. Alejandro Morales, Lourival D. Possani, Ernesto Ortiz, Teresa Romero-Gutiérrez   +5 more
doaj   +1 more source

Novel potassium channel blocker venom peptides from Mesobuthus gibbosus (Scorpiones: Buthidae)

Toxicon, 2013
In the present study, we report for the first time, the molecular, biochemical and electrophysiological characterization of the components present in the soluble venom from Mesobuthus gibbosus (Brullé, 1832). According to the epidemiological and clinical situation of scorpion envenomation cases M.
Diego-Garcia, Elia, Peigneur, Steve, Debaveye, Sarah, Gheldof, Eveline, Tytgat, Jan, Caliskan, Figen   +5 more
openaire   +3 more sources

Emerging cures for cancer: peptides from scorpion and spider venom

Highlights in Science, Engineering and Technology, 2022
Animal toxins have shown applicability in treatments of various diseases, here some investigations of scorpion and spider venom peptides as cancer treatments have been presented. Scorpion peptides are believed to have antitumor and analgesic effects and may present the potential to be applied in human medicine as a drug for cancer.
Jiayi He, Yedong Xue
openaire   +1 more source

Isolation, chemical and functional characterization of several new K+-channel blocking peptides from the venom of the scorpion Centruroides tecomanus [PDF]

, 2018
K
Balajthy, András, Bartók, Ádám, Becerril, Baltazar, Olamendi-Portugal, Timoteo, Panyi, György, Possani, Lourival D., Zamudio, Fernando Z.   +6 more
core   +1 more source

Unveiling the Diversity and Modifications of Short Peptides in Buthus martensii Scorpion Venom through Liquid Chromatography-High Resolution Mass Spectrometry

Toxins
More recently, short peptides in scorpion venom have received much attention because of their potential for drug discovery. Although various biological effects of these short peptides have been found, their studies have been hindered by the lack of ...
Ling Zeng, Cangman Zhang, Mingrong Yang, Jianfeng Sun, Jingguang Lu, Huixia Zhang, Jianfeng Qin, Wei Zhang, Zhihong Jiang   +8 more
doaj   +1 more source

Mass fingerprinting of the venom and transcriptome of venom gland of scorpion Centruroides tecomanus. [PDF]

PLoS ONE, 2013
Centruroides tecomanus is a Mexican scorpion endemic of the State of Colima, that causes human fatalities. This communication describes a proteome analysis obtained from milked venom and a transcriptome analysis from a cDNA library constructed from two ...
Laura L Valdez-Velázquez, Verónica Quintero-Hernández, Maria Teresa Romero-Gutiérrez, Fredy I V Coronas, Lourival D Possani   +4 more
doaj   +1 more source