Results 51 to 60 of about 5,167 (220)

A simple protocol for venom peptide barcoding in scorpions

EuPA Open Proteomics, 2014
AbstractScorpion venoms contain many species-specific peptides which target ion channels in cell membranes. Without harming the scorpions, these peptides can easily be extracted and detected by MALDI-TOF mass spectrometry. So far, only few studies compared the venom of different species solely for taxonomic purposes.
Schaffrath, Stephan, Predel, Reinhard
openaire   +1 more source

Proteomic endorsed transcriptomic profiles of venom glands from Tityus obscurus and T. serrulatus scorpions. [PDF]

PLoS ONE, 2018
Except for the northern region, where the Amazonian black scorpion, T. obscurus, represents the predominant and most medically relevant scorpion species, Tityus serrulatus, the Brazilian yellow scorpion, is widely distributed throughout Brazil, causing ...
Ursula Castro de Oliveira, Milton Yutaka Nishiyama, Maria Beatriz Viana Dos Santos, Andria de Paula Santos-da-Silva, Hipócrates de Menezes Chalkidis, Andreia Souza-Imberg, Denise Maria Candido, Norma Yamanouye, Valquíria Abrão Coronado Dorce, Inácio de Loiola Meirelles Junqueira-de-Azevedo   +9 more
doaj   +1 more source

Purification and characterization of a novel type of neurotoxic peptides from the venom of the Iranian scorpion Hemiscorpius lepturus [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Scorpion venom has toxic effects on mammals, insects and crustaceans.  Toxicogenic peptides are major contributors to the scorpion venom, which make it toxic. The Hemiscorpius lepturus (H.
Mahboob Maleki, Naser Mohammadpour Dounighi   +1 more
doaj   +1 more source

Are ticks venomous animals? [PDF]

, 2017
[Introduction]: As an ecological adaptation venoms have evolved independently in several species of Metazoa. As haematophagous arthropods ticks are mainly considered as ectoparasites due to directly feeding on the skin of animal hosts. Ticks are of major
Cabezas-Cruz, Alejandro, Valdés, James J.   +1 more
core   +1 more source

Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. [PDF]

, 2016
Scorpion venoms provide a rich source of anti-microbial peptides. Here we characterise three from the venom of Scorpion maurus palmatus. Smp13 is biologically inactive, despite sharing homology with other antimicrobial peptides, probably because it lacks
Abdel-Rahman, Andrews, Bahar, Baumann, Bobone, Calvete, Corzo, Dai, Dempsey, Gajski, Galanth, Glukhov, Hancock, Harrison, Hilliard, Holak, Huang, Jenssen, Jiang, Kaduk, Keith Miller, Kobayashi, Livermore, Ludtke, Matsuzaki, Melo, Moerman, Mohamed A. Abdel-Rahman, Mohamed M. Tawfik, Nelson, Nomura, Nomura, Park, Park, Patrick L. Harrison, Peter N. Strong, Powers, Rodríguez, Rodríguez, Shai, Shin, Sreerama, Teixeira, Torres-Larios, Urban, Whitmore, Yamaguchi, Yeaman, Yonezawa, Zasloff, Zasloff, Zeng, Zhang   +52 more
core   +1 more source

ScorpDb: A Novel Open-Access Database for Integrative Scorpion Toxinology

Toxins
Scorpion stings are a significant public health concern globally, particularly in tropical and subtropical regions. Scorpion venoms contain a diverse array of bioactive peptides, and different scorpion species around the world typically exhibit varying ...
Masoumeh Baradaran, Fatemeh Salabi, Masoud Mahdavinia, Elaheh Mohammadi, Babak Vazirianzadeh, Ignazio Avella, Seyed Mahdi Kazemi, Tim Lüddecke   +7 more
doaj   +1 more source

Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold [PDF]

Bioscience Reports, 2013
The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new scorpion venom-derived K+ channel toxin (named λ-MeuKTx-1) with an ICK fold through gene cloning, chemical synthesis, nuclear magnetic resonance spectroscopy, Ca2+ release measurements and ...
Gao, Bin, Harvey, Peta, Craik, David, Ronjat, Michel, de Waard, Michel, Zhu, Shunyi   +5 more
openaire   +3 more sources

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, Volume 137, Issue 27, July 1, 2025.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii

Toxins, 2016
Scorpion venom is deemed to contain many toxic peptides as an important source of natural compounds. Out of the two hundred proteins identified in Mesobuthus martensii (M. martensii), only a few peptide toxins have been found so far.
Ning Luan, Wang Shen, Jie Liu, Bo Wen, Zhilong Lin, Shilong Yang, Ren Lai, Siqi Liu, Mingqiang Rong   +8 more
doaj   +1 more source