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SDF-1 keeps HSC quiescent at home

Blood, 2011
In this issue of Blood , Tzeng et al report on the generation of adult, conditional SDF-1–deficient mice in which HSC quiescence and endosteal niche localization are impaired.[1][1] The chemokine stromal cell–derived factor 1 (SDF-1; CXCL12), and its major receptor CXCR4, regulate many ...
Tomer, Itkin, Tsvee, Lapidot
openaire   +2 more sources

Functional Characterization of SDF-1 Proximal Promoter

Journal of Molecular Biology, 2005
Stromal-cell derived factor 1 (SDF1) is a CXC chemokine that binds and signals through the CXCR4 receptor, playing an essential role in embryonic B lymphopoiesis, myelopoiesis and organogenesis. The CXCR4/SDF1 pathway is associated with several pathologies.
Carelia, García-Moruja   +9 more
openaire   +2 more sources

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