Results 251 to 260 of about 63,696 (276)

SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect

Journal of Bone and Mineral Metabolism, 2020
Recent studies have indicated the potential of stem cell therapy in combination with cytokines to restore the bone repair via migration and homing of stem cells to the defected area. The present study aimed to investigate the mobilization and recruitment of mesenchymal stem cells (MSCs) in response to SDF-1.Herein, the knockout rat model of the bone ...
Heli, Zhang, Xijing, Li, Junfeng, Li, Lili, Zhong, Xue, Chen, Si, Chen   +5 more
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SDF-1 Signaling in Myeloid Malignancies,

Blood, 2011
Abstract Abstract 3824 The factor SDF-1 (stromal derived factor-1) was identified as an important chemoattractant factor produced by bone marrow cells. SDF-1 acts on its receptor CXCR4 and plays primordial function in migration, retention and development of hematopoietic progenitors in bone marrow.
Rita de Cassia Carvalho Melo, Carolina Bigarella, Matheus Manolo Arouca, Mariana Ozello Baratti, Fabiola Traina, Sara T Olalla Saad   +5 more
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Serum albumin strongly influences SDF-1 dependent migration

International Journal of Hematology, 2009
Stem cell migration is largely regulated by the chemokine SDF-1 and its receptor CXCR4. In the present study, we analyzed the effect of protein on SDF-1 dependent chemotaxis using CXCR4 expressing primary CD34+ hematopoietic progenitor cells for transwell migration assays.
Martin F, Ryser, Sebastian, Thieme, Martin, Bornhäuser, Romy, Lehmann, Sebastian, Brenner   +4 more
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Targeting SDF-1 in multiple myeloma tumor microenvironment

Cancer Letters, 2016
Multiple myeloma (MM) is a type of B-cell malignancy that remains incurable to date. The bone marrow (BM) microenvironment plays a crucial role in MM progression. The chemokine SDF-1 (CXCL12) is an important actor of the BM microenvironment that has the ability to regulate numerous processes related to its malignant transformation during MM development.
Juliette M C, Bouyssou, Irene M, Ghobrial, Aldo M, Roccaro   +2 more
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SDF-1: the repulsive chemokine

Immunology Today, 2000
1 Mark C. Poznansky et al. (2000) Active movement of T cells away from a chemokine. Nat. Med. 6, 543–548Chemokines set up concentration (or chemotactic) gradients in tissue, which influence target cells to migrate towards their source – ‘up’ concentration gradients.
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CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion

Journal of Molecular Histology, 2004
Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-protein-coupled seven-span transmembrane receptors present on plasma membranes of target cells are the major regulators of cell trafficking. In addition some chemokines have been reported to modulate cell survival and growth.
Magda, Kucia, Kacper, Jankowski, Ryan, Reca, Marcin, Wysoczynski, Laura, Bandura, Daniel J, Allendorf, Jin, Zhang, Janina, Ratajczak, Mariusz Z, Ratajczak   +8 more
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Increase in Circulating SDF‐1 after Treatment with Sulfated Glycans

Annals of the New York Academy of Sciences, 2001
Abstract: SDF‐1 is a potent chemoattractant for mature white blood cells and hemopoietic stem/progenitor cells (HPCs). An important role for this chemo‐kine in mobilization has been postulated, but in vivo studies directly addressing its effects are lacking.
E A, Sweeney, T, Papayannopoulou
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Chemosensitivity Is Differentially Regulated by SDF-1/CXCR4 and SDF-1/CXCR7 Axes in Acute Lymphoblastic Leukemia.

Blood, 2012
Abstract Abstract 2441 SDF-1 (CXCL12) is a chemokine vastly secreted from bone marrow-stromal cells (BM-SC), and plays a pivotal role for multiple biological events in a variety of cells. Hematopoietic stem cells express its receptor CXCR4 at high levels and the SDF-1/CXCR4 system is profoundly implicated in their homing ...
Norie Ando, Yoshiyuki Furuichi, Shin Kasai, Keiko Kagami, Kumiko Goi, Takeshi Inukai, Kanji Sugita   +6 more
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SDF-1 stimulates neurite growth on inhibitory CNS myelin

Molecular and Cellular Neuroscience, 2009
Impaired axonal regeneration is a common observation after central nervous system (CNS) injury. The stromal cell-derived factor-1, SDF-1/CXCL12, has previously been shown to promote axonal growth in the presence of potent chemorepellent molecules known to be important in nervous system development.
Jessica, Opatz, Patrick, Küry, Nora, Schiwy, Anne, Järve, Veronica, Estrada, Nicole, Brazda, Frank, Bosse, Hans Werner, Müller   +7 more
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SDF-1/CXCR4 Interactions in Idiopathic Myelofibrosis.

Blood, 2005
Abstract Interactions between SDF-1 and CXCR4 determine in part the retention, migration and mobilization of hematopoietic stem cells and endothelial progenitor cells during steady state hematopoiesis and following a variety of stimuli.
Mingjiang Xu, Edward Bruno, Hongyu Ni, Vittorio Rosti, Margherita Massa, Giovanni Barosi, Ronald Hoffman   +6 more
openaire   +1 more source