Results 61 to 70 of about 1,865,436 (219)

Cyclic di-AMP alleviates periodontitis by activating PI3K/Akt/Nrf2 pathways

Frontiers in Cellular and Infection Microbiology
Emerging research demonstrates the regulatory effects of c-di-AMP, a bacterial-derived small molecule secondary messenger, on host immune responses and promoting resistance against infection-related diseases. This study aims to elucidate the role of c-di-
Kaihua Luo, Kaihua Luo, Qinrui Wu, Qinrui Wu, Zhengyi Li, Yajie Wu, Yajie Wu, Zhifei Su, Zhifei Su, Fangjie Zhou, Fangjie Zhou, Qinyang Li, Qinyang Li, Biao Ren, Yuqing Li, Jiyao Li, Jiyao Li, Xian Peng   +17 more
doaj   +1 more source

Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2′,3′-cyclic guanosine monophosphate

Nature Communications, 2023
Previous studies have demonstrated that bis-(3',5')-cyclic diguanosine monophosphate (bis-3',5'-c-di-GMP) is a ubiquitous second messenger employed by bacteria. Here, we report that 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) controls the important
Xia Li, Wenfang Yin, Junjie Desmond Lin, Yong Zhang, Quan Guo, Gerun Wang, Xiayu Chen, Binbin Cui, Mingfang Wang, Min Chen, Peng Li, Ya-Wen He, Wei Qian, Haibin Luo, Lian-Hui Zhang, Xue-Wei Liu, Shihao Song, Yinyue Deng   +17 more
doaj   +1 more source

The role of the neuromodulator adenosine in alcohols actions. [PDF]

, 1997
The interaction between the neuromodulator adenosine and adenosine receptors on the surface of neurons modifies the neurons responses to neurotransmitters.
Diamond, Ivan, Dohrman, D, Gordon, A
core  

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers [PDF]

Nature, 2017
In many prokaryotes, type III clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems detect and degrade invasive genetic elements by an RNA-guided, RNA-targeting multisubunit interference complex. The CRISPR-associated protein Csm6 additionally contributes to interference by functioning as a standalone RNase ...
Niewoehner, Ole, Garcia-Doval, Carmela, Rostøl, Jakob T, Berk, Christian, Schwede, Frank, Bigler, Laurent, Hall, Jonathan, Marraffini, Luciano A, Jinek, Martin   +8 more
openaire   +2 more sources

Multi-messenger picture of compact binary mergers

, 2015
In the last decade, enormous progress has been achieved in the understanding of the various facets of coalescing double neutron star and neutron black hole binary systems. One hopes that the mergers of such compact binaries can be routinely detected with
Rosswog, S.
core   +1 more source

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]

, 1933
G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Chrousos, G. P., Karl, M., Reincke, Martin, Travis, W.   +3 more
core  

Integrated Metabolomics and Proteomics Analysis Revealed Second Messenger System Disturbance in Hippocampus of Chronic Social Defeat Stress Rat

Frontiers in Neuroscience, 2019
Depression is a common and disabling mental disorder characterized by high disability and mortality, but its physiopathology remains unclear. In this study, we combined a non-targeted gas chromatography-mass spectrometry (GC-MS)-based metabolomic ...
Li-Ning Yang, Li-Ning Yang, Jun-Cai Pu, Jun-Cai Pu, Lan-Xiang Liu, Lan-Xiang Liu, Guo-Wei Wang, Xin-Yu Zhou, Yu-Qing Zhang, Yi-Yun Liu, Yi-Yun Liu, Peng Xie, Peng Xie   +12 more
doaj   +1 more source

Seamless mobility with personal servers [PDF]

, 2003
We describe the concept and the taxonomy of personal servers, and their implications in seamless mobility. Personal servers could offer electronic services independently of network availability or quality, provide a greater flexibility in the choice of ...
Bylund, Markus, Segall, Zary
core   +1 more source

Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors

Biomolecules
Cyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia, Ge Yun, Bingxin Liu, Xinxin Li, Meiling Jiang, Xinlu Yu, Jing Zhang, Yufei Han, Dan Liu, Junlong Zhao, Yuanyuan Wang, Gukui Chen   +11 more
doaj   +1 more source

Classification of muscarinic responses in hippocampus in terms of receptor subtypes and second-messenger systems: electrophysiological studies in vitro

Journal of Neuroscience, 1988
The hippocampal slice preparation was used to classify cholinergic effects in terms of muscarinic receptor subtypes (M1 or M2) and biochemical effector systems linked to these effects in CA1 pyramidal cells.
P. Dutar, R. Nicoll
semanticscholar   +1 more source