Carcinogenic and anticancer activities of microbiota-derived secondary bile acids [PDF]
Frontiers in OncologySecondary bile acids (SBAs), which are metabolites produced by gut microbiota, have been implicated in both carcinogenic and anticancer processes. This review explores the dual role of SBAs, focusing on their molecular mechanisms and biological effects ...
Mobina Kouhzad +7 more
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Secondary Bile Acids and Tumorigenesis in Colorectal Cancer [PDF]
Frontiers in Oncology, 2022 Colorectal cancer (CRC) is one of the most common and deadly cancers in the world and is a typical inflammatory tumor. In recent years, the incidence of CRC has been increasing year by year.
Yujing Liu +5 more
doaj +5 more sources
Specific Secondary Bile Acids Control Chicken Necrotic Enteritis [PDF]
Pathogens, 2021 Necrotic enteritis (NE), mainly induced by the pathogens of Clostridium perfringens and coccidia, causes huge economic losses with limited intervention options in the poultry industry.
Mohit Bansal +9 more
doaj +6 more sources
Phenotyping the Chemical Communications of the Intestinal Microbiota and the Host: Secondary Bile Acids as Postbiotics [PDF]
CellsThe current definition of a postbiotic is a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”.
Ginevra Urbani +5 more
doaj +3 more sources
Disease-Associated Gut Microbiota Reduces the Profile of Secondary Bile Acids in Pediatric Nonalcoholic Fatty Liver Disease [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Children with nonalcoholic fatty liver disease (NAFLD) display an altered gut microbiota compared with healthy children. However, little is known about the fecal bile acid profiles and their association with gut microbiota dysbiosis in pediatric NAFLD. A
Jiake Yu +5 more
doaj +3 more sources
Research on Gut Microbiota-Derived Secondary Bile Acids in Cancer Progression. [PDF]
Integr Cancer Ther, 2022 The interaction between gut microbiota-derived metabolites and the body plays a significant role in the occurrence and development of cancer. Secondary bile acids (BAs) are the important products produced from gut microbial fermentation of primary BAs ...
Yang R, Qian L.
europepmc +5 more sources
The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice [PDF]
Gut Microbes, 2021 Extibacter muris is a newly described mouse gut bacterium which metabolizes cholic acid (CA) to deoxycholic acid (DCA) via 7α-dehydroxylation. Although bile acids influence metabolic and inflammatory responses, few in vivo models exist for studying their
Theresa Streidl +20 more
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Amelioration of Colitis by a Gut Bacterial Consortium Producing Anti-Inflammatory Secondary Bile Acids. [PDF]
Microbiol Spectr, 2023 Secondary bile acids have been reported to be anti-inflammatory, yet it remains to be studied whether introducing selected bacteria strains to restore bile acid metabolism of the gut microbiome can alleviate intestinal inflammation.
Zhou C, Wang Y, Li C, Xie Z, Dai L.
europepmc +2 more sources
Secondary bile acids function through the vitamin D receptor in myeloid progenitors to promote myelopoiesis. [PDF]
Blood Adv, 2023 Key Points • Secondary bile acids interact directly with hematopoietic progenitors to promote myelopoiesis in a VDR-dependent manner.• Secondary bile acids elevated expression of genes associated with differentiation and proliferation in myeloid ...
Thompson B +9 more
europepmc +2 more sources
Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease. [PDF]
Front Endocrinol (Lausanne), 2023 The gastrointestinal tract hosts the largest ecosystem of microorganisms in the body. The metabolism of ingested nutrients by gut bacteria produces novel chemical mediators that can influence chemosensory cells lining the gastrointestinal tract ...
Masse KE, Lu VB.
europepmc +2 more sources