Results 11 to 20 of about 323,138 (302)

Impact of Primary and Secondary Bile Acids on Clostridioides difficile Infection. [PDF]

Pol J Microbiol, 2022
Primary bile acids (BAs), synthesized from cholesterol in the liver, after their secretion with bile into the intestinal lumen, are transformed by gut microbiota to secondary BAs. As natural detergents, BAs play a key role in the digestion and absorption
Łukawska A, Mulak A.
europepmc   +6 more sources

Secondary bile acids improve risk prediction for non-invasive identification of mild liver fibrosis in nonalcoholic fatty liver disease. [PDF]

Aliment Pharmacol Ther, 2023
Dysregulated bile acid (BA) metabolism has been linked to steatosis, inflammation, and fibrosis in nonalcoholic fatty liver disease (NAFLD).
Liu AN, Xu CF, Liu YR, Sun DQ, Jiang L, Tang LJ, Zhu PW, Chen SD, Liu WY, Wang XD, Targher G, Byrne CD, Wong VW, Fu J, Su MM, Loomba R, Zheng MH, Ni Y.   +17 more
europepmc   +2 more sources

Gut Microbiota-Mediated Elevated Production of Secondary Bile Acids in Chronic Unpredictable Mild Stress. [PDF]

Front Pharmacol, 2022
A growing body of evidence suggests that gut microbiota could participate in the progression of depression via the microbiota–gut–brain axis. However, the detailed microbial metabolic profile changes in the progression of depression is still not fully ...
Qu Y, Su C, Zhao Q, Shi A, Zhao F, Tang L, Xu D, Xiang Z, Wang Y, Wang Y, Pan J, Yu Y.   +11 more
europepmc   +2 more sources

Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte/macrophage recruitment. [PDF]

Gut Microbes, 2022
Although post-cholecystectomy (PC) patients usually have gastrointestinal complications and a higher risk of colorectal cancer, previous studies undetected a heightened risk of inflammatory bowel disease.
Liu Y, Xu J, Ren X, Zhang Y, Ke Z, Zhou J, Wang Y, Zhang Y, Liu Y.   +8 more
europepmc   +2 more sources

Bile Acid 7α-Dehydroxylating Gut Bacteria Secrete Antibiotics that Inhibit Clostridium difficile: Role of Secondary Bile Acids. [PDF]

Cell Chem Biol, 2019
Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study was to determine how C. scindens regulates C. difficile growth in vitro and if these interactions might relate to the regulation of gut microbiome structure in vivo. The
Kang JD, Myers CJ, Harris SC, Kakiyama G, Lee IK, Yun BS, Matsuzaki K, Furukawa M, Min HK, Bajaj JS, Zhou H, Hylemon PB.   +11 more
europepmc   +5 more sources

Correlation between Peptacetobacter hiranonis, the baiCD Gene, and Secondary Bile Acids in Dogs. [PDF]

Animals (Basel)
Simple Summary Dysmetabolism of bile acids has been linked to chronic enteropathy in dogs. Peptacetobacter (Clostridium) hiranonis has been described as the major species responsible for converting primary into secondary bile acids in dogs.
Correa Lopes B, Chen CC, Sung CH, Ishii PE, Medina LFDC, Gaschen FP, Suchodolski JS, Pilla R.   +7 more
europepmc   +2 more sources

Isomaltulose Exhibits Prebiotic Activity, and Modulates Gut Microbiota, the Production of Short Chain Fatty Acids, and Secondary Bile Acids in Rats. [PDF]

Molecules, 2021
In vitro experiments have indicated prebiotic activity of isomaltulose, which stimulates the growth of probiotics and the production of short chain fatty acids (SCFAs). However, the absence of in vivo trials undermines these results.
Yang ZD, Guo YS, Huang JS, Gao YF, Peng F, Xu RY, Su HH, Zhang PJ.   +7 more
europepmc   +2 more sources

Systematic identification of secondary bile acid production genes in global microbiome

mSystems
Microbial metabolism of bile acids (BAs) is crucial for maintaining homeostasis in vertebrate hosts and environments. Although certain organisms involved in bile acid metabolism have been identified, a global, comprehensive elucidation of the microbes ...
Yuwei Yang, Wenxing Gao, Ruixin Zhu, Liwen Tao, Wanning Chen, Xinyue Zhu, Mengping Shen, Tingjun Xu, Tingting Zhao, Xiaobai Zhang, Lixin Zhu, Na Jiao   +11 more
doaj   +4 more sources

The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis. [PDF]

Physiol Rep, 2020
Increased epithelial permeability is a key feature of IBD pathogenesis and it has been proposed that agents which promote barrier function may be of therapeutic benefit. We have previously reported the secondary bile acid, ursodeoxycholic acid (UDCA), to
Lajczak-McGinley NK, Porru E, Fallon CM, Smyth J, Curley C, McCarron PA, Tambuwala MM, Roda A, Keely SJ.   +8 more
europepmc   +2 more sources

Secondary Bile Acids and Short Chain Fatty Acids in the Colon: A Focus on Colonic Microbiome, Cell Proliferation, Inflammation, and Cancer. [PDF]

Int J Mol Sci, 2019
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial metabolites in the colon, cause opposing effects on colonic inflammation at chronically high physiological levels. Primary BAs play critical roles in cholesterol
Zeng H, Umar S, Rust B, Lazarova D, Bordonaro M.   +4 more
europepmc   +2 more sources